The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo

2021 ◽  
Author(s):  
V. P. Nikolin ◽  
N. A. Popova ◽  
V. I. Kaledin ◽  
O. A. Luzina ◽  
A. L. Zakharenko ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Acid Derivative ◽  
Usnic Acid ◽  
Transplanted Tumors

An usnic acid derivative as new tweezer for non-covalent aromatic interaction complex

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
B Legouin ◽  
M Chollet-Krugler ◽  
S Tomasi ◽  
P Uriac ◽  
P van de Weghe
Keyword(s):  
Acid Derivative ◽  
Usnic Acid ◽  
Aromatic Interaction

Promising nanogels loaded with usnic acid for oral ulcer treatment: development, characterization, and in vivo evaluation in rabbits

2021 ◽  
Vol 26 (4) ◽  
pp. 431-443
Author(s):  
Nesrin Coşkunmeriç ◽  
Neslihan Üstündağ Okur ◽  
Mehmet Evren Okur ◽  
Şule Ayla ◽  
Ayşegül Yoltaş ◽  
...  
Keyword(s):  
Usnic Acid ◽  
Oral Ulcer ◽  
In Vivo Evaluation ◽  
Treatment Development ◽  
Ulcer Treatment

Tat-BMPs-PAMAM Conjugates Enhance Therapeutic Effect of Small Interference RNA on U251 Glioma Cells In Vitro and In Vivo

2010 ◽  
Vol 21 (4) ◽  
pp. 417-426 ◽  
Author(s):  
Lei Han ◽  
Anling Zhang ◽  
Hanjie Wang ◽  
Peiyu Pu ◽  
Xinguo Jiang ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Glioma Cells ◽  
Small Interference Rna ◽  
Interference Rna

scholarly journals In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms

2017 ◽  
Vol 55 (1) ◽  
pp. 1256-1262 ◽  
Author(s):  
Pimporn Anantaworasakul ◽  
Hiroshi Hamamoto ◽  
Kazuhisa Sekimizu ◽  
Siriporn Okonogi
Keyword(s):  
Antibacterial Activity ◽  
Therapeutic Effect ◽  
Sesbania Grandiflora ◽  
In Vitro Antibacterial Activity

scholarly journals The Natural Compound Hydrophobic Usnic Acid and Hydrophilic Potassium Usnate Derivative: Applications and Comparisons

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5995
Author(s):  
Hallysson Douglas Andrade de Araújo ◽  
Hianna Arely Milca Fagundes Silva ◽  
José Guedes da Silva Júnior ◽  
Mônica Camelo Pessoa de Azevedo Albuquerque ◽  
Luana Cassandra Breitenbach Barroso Coelho ◽  
...  
Keyword(s):  
Biological Activities ◽  
Structural Characteristics ◽  
Usnic Acid ◽  
Raw Material ◽  
Structural Modifications ◽  
Hydrophobic Molecule ◽  
Antiparasitic Agents ◽  
Toxic Molecule

Usnic acid is the best-studied lichen metabolite, presenting several biological activities, such as antibacterial, immunostimulating, antiviral, antifungal, anti-inflammatory, and antiparasitic agents; despite these relevant properties, it is a hydrophobic and toxic molecule. In this context, scientific research has driven the development of innovative alternatives, considering usnic acid as a source of raw material in obtaining new molecules, allowing structural modifications (syntheses) from it. The purpose is to optimize biological activities and toxicity, with less concentration and/or response time. This work presents a literature review with an analogy of the hydrophobic molecule of usnic acid with its hydrophilic derivative of potassium usnate, emphasizing the elucidation and structural characteristics, biological activities, and toxicological aspects of both molecules, and the advantages of using the promising derivative hydrophilic in different in vitro and in vivo assays when compared to usnic acid.

Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy

2012 ◽  
Vol 52 (2) ◽  
pp. 377-391 ◽  
Author(s):  
Chien-Ju Lin ◽  
Chin-Cheng Lee ◽  
Yung-Luen Shih ◽  
Tsung-Yao Lin ◽  
Sheng-Hao Wang ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Therapeutic Effect

Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair

Nanomedicine ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 273-288 ◽  
Author(s):  
Chun Liu ◽  
Yun Li ◽  
Zhijian Yang ◽  
Zhiyou Zhou ◽  
Zhihao Lou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Effect ◽  
Bone Marrow Mscs ◽  
In Vivo Experiments ◽  
Marrow Mesenchymal Stem Cells ◽  
Cartilage Diseases

The effectiveness of mesenchymal stem cells (MSC) in the treatment of cartilage diseases has been demonstrated to be attributed to the paracrine mechanisms, especially the mediation of exosomes. But the exosomes derived from unsynchronized MSCs may be nonhomogeneous and the therapeutic effect varies between samples. Aim: To produce homogeneous and more effective exosomes for the regeneration of cartilage. Materials & methods: In this study we produced specific exosomes from bone marrow MSCs (BMSC) through kartogenin (KGN) preconditioning and investigated their performance in either in vitro or in vivo experiments. Results & conclusion: The exosomes derived from KGN-preconditioned BMSCs (KGN-BMSC-Exos) performed more effectively than the exosomes derived from BMSCs (BMSC-Exos). KGN preconditioning endowed BMSC-Exos with stronger chondral matrix formation and less degradation.

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