Nitrogen-Containing Heterocyclic Derivatives of Maleopimaric Acid by Carboxyl Function and their Antioxidant Activity

2019 ◽  
Vol 55 (1) ◽  
pp. 47-51 ◽  
Author(s):  
R. M. Sultanova ◽  
I. M. Sakhautdinov
Keyword(s):  
Antioxidant Activity ◽  
Maleopimaric Acid ◽  
Heterocyclic Derivatives ◽  
Derivatives Of

Mono- and bis-dipicolinic acid heterocyclic derivatives – thiosemicarbazides, triazoles, oxadiazoles and thiazolidinones as antifungal and antioxidant agents

2017 ◽  
Vol 23 (1) ◽  
Author(s):  
Maja Molnar ◽  
Valentina Pavić ◽  
Bojan Šarkanj ◽  
Milan Čačić ◽  
Dubravka Vuković ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antifungal Agents ◽  
Dipicolinic Acid ◽  
Antioxidant Agents ◽  
Heterocyclic Derivatives ◽  
Antimicrobial And Antioxidant Activity ◽  
Derivatives Of

AbstractA series of dipicolinic acid derivatives was synthesized and investigated for antimicrobial and antioxidant activity. Mono and bis derivatives of ethyl dipicolinate were utilized as starting materials for synthesis of mono- and bis-hydrazides. Thiosemicarbazides were obtained by reaction of hydrazides with isothiocyanates and cyclized into triazoles, thiadiazoles, oxadiazoles and thiazolidinones. Some of these products, especially those incorporating a thiazolidinone moiety in their structure, are excellent antioxidants, DPPH scavengers and antifungal agents.

Synthesis, Cytotoxicity and Antioxidant Activity of New Analogs of RC-121 Synthetic Derivatives of Somatostatin

2019 ◽  
Vol 18 (10) ◽  
pp. 1417-1424 ◽  
Author(s):  
Emilia Naydenova ◽  
Diana Wesselinova ◽  
Svetlana Staykova ◽  
Ivan Goshev ◽  
Ljubomir Vezenkov
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Capacity ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Colorectal Cancer Cell Line ◽  
Cervical Cancer Cell Line ◽  
Synthetic Derivatives ◽  
Derivatives Of

Background: Based on the structure of RC-121 (D-Phe-c (Cys-Tyr-D-Trp-Lys-Val-Cys)-Thr-NH2, - synthetic derivatives of somatostatin), some analogs were synthesized and tested for in vitro cytotoxic and antioxidant activity. Objectives: The new analogs were modifyed at position 5 with Dap (diaminopropanoic acid), Dab (diaminobutanoic acid) and Orn and at position 6 with the unnatural amino acids Tle (t-leucine). Methods: The in vitro cytotoxic effects of the substances were investigated against a panel of human tumor cell lines HT-29 (Human Colorectal Cancer Cell Line), MDA-MB-23 (Human Breast Cancer Cell Line), Hep G-2 (Human Hepatocellular Carcinoma Cell Line) and HeLa (cervical cancer cell line). The antioxidant capacities were tested by ORAC (Oxygen Radical Antioxidant Capacity) and HORAC (Hydroxyl Radical Averting Capacity) methods. Results: All substances expressed significantly higher antioxidant capacity by comparison with galic acid and Trolox. All substances showed considerable antioxidant capacity as well. Compound 2T (D-Phe-c(Cys-Tyr-DTrp- Dap-Tle-Cys)-Thr-NH2)had the highest antioxidant effect. The compound 4T (D-Phe-c(Cys-Tyr-D-Trp- Orn-Tle-Cys)-Thr-NH2) displayed antiproliferative effect on HeLa cells with IC50 30 µM. The peptide analog 3T (D-Phe-c(Cys-Tyr-D-Trp-Lys-Tle-Cys)-Thr-NH2) exerted the most pronounced inhibition on the cell vitality up to 53%, 56% and 65% resp. against MDA-MB-23, Hep G-2, HeLa in the higher tested concentration. Conclusion: The somatostatin analogs showed moderate influence on the vitality of different tumor cells and could be used in changing their pathology.

Heterocyclic derivatives of purines. 5. Nucleophilic substitution in series of imidazo[1,2-f]purine derivatives

1984 ◽  
Vol 20 (3) ◽  
pp. 330-334
Author(s):  
S. N. Garmash ◽  
B. A. Priimenko ◽  
N. A. Klyuev ◽  
N. I. Romanenko ◽  
A. K. Sheinkman
Keyword(s):  
Nucleophilic Substitution ◽  
Purine Derivatives ◽  
Heterocyclic Derivatives ◽  
In Series ◽  
Derivatives Of

Antioxidant activity of some derivatives of 9-thiabicyclo[3,3,1]nonane in rubber and rubber vulcanizates

1992 ◽  
Vol 37 (1) ◽  
pp. 1-5 ◽  
Author(s):  
J.-M. Herdan ◽  
Liana Cira ◽  
Maria Giurginca ◽  
G. Ivan
Keyword(s):  
Antioxidant Activity ◽  
Derivatives Of

Synthesis and Antioxidant Activity of New N-Containing Hybrid Derivatives of Gallic and Ursolic Acids

2021 ◽  
Author(s):  
S. A. Popov ◽  
C. Wang ◽  
Z. Qi ◽  
E. E. Shul’ts ◽  
M. Turks
Keyword(s):  
Antioxidant Activity ◽  
Derivatives Of

Angular condensed heterocyclic derivatives of ?-naphthol

1970 ◽  
Vol 6 (4) ◽  
pp. 513-515
Author(s):  
T. Kh. Gladysheva ◽  
M. V. Gorelik
Keyword(s):  
Heterocyclic Derivatives ◽  
Derivatives Of

scholarly journals Synthesis of bis-Heterocyclic Derivatives of Thiohydantoin

INEOS OPEN ◽  
2021 ◽  
Vol 4 ◽  
Author(s):  
O. N. Gorunova ◽  
◽  
N. A. Bystrova ◽  
K. A. Kochetkov ◽  
◽  
...  
Keyword(s):  
Structural Modification ◽  
Suggested Approach ◽  
Heterocyclic Derivatives ◽  
Derivatives Of

The possibility of structural modification of thiohydantoin derivatives via amidoalkylation under the action of a range of cyclic hemiamidals is demonstrated. The suggested approach provides, in particular, unsymmetrical nitrogen-containing bis-heterocyclic systems with pharmacologically relevant groups that are difficult to obtain by other methods.

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