Increased Risk of Progression to Gastric Adenocarcinoma in Patients with Non-dysplastic Gastric Intestinal Metaplasia Versus a Control Population

2020 ◽  
Vol 65 (11) ◽  
pp. 3316-3323
Author(s):  
Rohit Dhingra ◽  
Nikola S. Natov ◽  
Yazan Daaboul ◽  
Moises Guelrud ◽  
Abraham Cherukara ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Gastric Adenocarcinoma ◽  
Control Population ◽  
Gastric Intestinal Metaplasia ◽  
Increased Risk ◽  
Risk Of Progression

scholarly journals CD10 and Das1: A Biomarker Study Using Immunohistochemistry to Subtype Gastric Intestinal Metaplasia

2021 ◽  
Author(s):  
Athanasios Koulis ◽  
Natasha Costanzo ◽  
Catherine Mitchell ◽  
Stephen Lade ◽  
David Goode ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
High Sensitivity ◽  
High Specificity ◽  
Expression Data ◽  
Gastric Intestinal Metaplasia ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
Risk Of Progression ◽  
Low Sensitivity ◽  
Digital Quantification

Abstract Background: Intestinal metaplasia (IM) is considered a key pivot point in the Correa model of gastric cancer (GC). It is histologically subtyped into the complete and incomplete subtypes, the latter being associated with a greater risk of progression. However, the clinical utility of IM subtyping remains unclear, partially due to the absence of reliable defining biomarkers.Methods: Based on gene expression data and existing literature, we selected CD10 and Das1 as candidate biomarkers to distinguish complete and incomplete IM glands in tissues from patients without GC (IM-GC) and patients with GC (IM+GC). Immunohistochemical staining of individually subtyped IM glands was scored after blinding by two researchers using tissue belonging to both IM-GC and IM+GC patients. Whole tissue Das1 staining was further assessed using digital image quantification (cellSens Dimension, Olympus).Results: Across both cohorts CD10 stained the IM brush border and was shown to have a high sensitivity (87.5% and 94.9% in IM-GC and IM+GC patients respectively) and specificity (100.0% and 96.7% respectively) with an overall AUROC of 0.944 for complete IM glands. By contrast Das1 stained mainly goblet cells and the apical membrane of epithelial cells, mostly of incomplete IM glands with a low sensitivity (28.6% and 29.3% in IM-GC and IM+GC patients respectively) but high specificity (98.3% and 85.1% respectively) and an overall AUROC of 0.603 for incomplete IM glands. A combined logistic regression model showed a significant increase in AUROC for detecting complete IM glands (0.955 vs 0.970). Whole tissue digital quantification of Das1 staining showed a significant association with incomplete IM compared to complete IM, both in IM-GC and in IM+GC patients (p=0.016 and p=0.009 respectively, Mann-Whitney test and unpaired t test used). Additionally, complete IM in IM+GC patients exhibited significantly more Das1 staining than in IM-GC patients (p=0.019, Mann-Whitney test). Conclusions: These findings suggest that CD10 is an outstanding biomarker for complete IM and Das1 may be useful as a secondary biomarker for IM glands at greater risk of progression irrespective of IM subtype. Overall, the clinical use of these biomarkers could lead to improved patient stratification and targeted surveillance.

scholarly journals The Prevalence of Gastric Intestinal Metaplasia and Distribution ofHelicobacter pyloriInfection, Atrophy, Dysplasia, and Cancer in Its Subtypes

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Sehmus Olmez ◽  
Mehmet Aslan ◽  
Remzi Erten ◽  
Suleyman Sayar ◽  
Irfan Bayram
Keyword(s):  
Intestinal Metaplasia ◽  
Gastric Adenocarcinoma ◽  
Cancer Development ◽  
Common Finding ◽  
Gastric Intestinal Metaplasia ◽  
Type Iii ◽  
High Prevalence ◽  
H Pylori ◽  
Clinical Records ◽  
Main Factor

Objectives. Gastric intestinal metaplasia (IM) is frequently encountered and is considered a precursor of gastric adenocarcinoma. In the Van region of Turkey, gastric adenocarcinoma incidence is high but the prevalence of gastric IM is not known.Helicobacter pylori(H. pylori) infection is a main factor leading to atrophy, IM, and cancer development in the stomach. The aim of the current study was to investigate the prevalence of IM and its subtypes and the prevalence ofH. pyloriinfection, atrophy, dysplasia, and cancer in gastric IM subtypes.Materials and Methods. This retrospective study was conducted on 560 IM among the 4050 consecutive patients who were undergoing esophagogastroduodenoscopy (EGD) with biopsy between June 2010 and October 2014. Clinical records and endoscopic and histopathologic reports of patients with IM were analyzed.Results. The prevalence of gastric IM was 13.8%. The prevalence of incomplete IM was statistically significantly higher than complete IM. Type III IM was the most frequent subtype.Conclusions. Gastric IM is a common finding in patients undergoing EGD with biopsy in this region. High prevalence of incomplete type IM, especially type III, can be associated with the high prevalence of gastric cancer in our region.

The Incidence of Gastric Adenocarcinoma Among Patients With Gastric Intestinal Metaplasia

2016 ◽  
Vol 50 (7) ◽  
pp. 532-537 ◽  
Author(s):  
Teng-Yu Lee ◽  
Ren-Ching Wang ◽  
Yi-Chia Lee ◽  
Jaw-Town Lin ◽  
Hsiu J. Ho ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Gastric Adenocarcinoma ◽  
Gastric Intestinal Metaplasia

Risk of Progression of Gastric Intestinal Metaplasia Is Significantly Greater When Detected in Both Antrum and Body

2020 ◽  
Author(s):  
Anthony O’Connor ◽  
Adam Bowden ◽  
Eoin Farrell ◽  
Joshua Weininger ◽  
Stephen Crowther ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Gastric Intestinal Metaplasia ◽  
Risk Of Progression

Association of gastric intestinal metaplasia and East Asian ethnicity with the risk of gastric adenocarcinoma in a U.S. population

2018 ◽  
Vol 87 (4) ◽  
pp. 1023-1028 ◽  
Author(s):  
Alyssa Y. Choi ◽  
Lisa L. Strate ◽  
Matthew C. Fix ◽  
Rodney A. Schmidt ◽  
Alexander R. Ende ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Gastric Adenocarcinoma ◽  
East Asian ◽  
Asian Ethnicity ◽  
Gastric Intestinal Metaplasia

Aquaporin 3 Expression Pattern in Gastric Diseases and its significance

2020 ◽  
Author(s):  
Heng Li ◽  
Xudong Dai ◽  
Jin Dou ◽  
Hualin Xu ◽  
Qi Min ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Ulcer ◽  
Intestinal Metaplasia ◽  
Gastric Adenocarcinoma ◽  
Treatment Strategy ◽  
Gastric Carcinogenesis ◽  
Gastric Erosion ◽  
Gastric Diseases ◽  
Aquaporin 3 ◽  
Gastric Intestinal Metaplasia

Abstract Background Aquaporin 3(AQP3) has been implicated in gastric intestinal metaplasia and gastric cancer, and considered as a biomarker to improve treatment strategy. Accumulating evidence suggests that AQP3 is involved in the gastric carcinogenesis and the disease progression. However, whether AQP3 is involved in the transformation from gastritis to gastric cancer remain elusive. In this study, we intended to realized the expression pattern and its significance of AQP3 in different gastric diseases. Methods A total of 101 patients diagnosed with gastric diseases were included in the study. A gastric tissue biopsy was taken from the gastric antrum during endoscopic examination. Expression of AQP3 protein is determined by immunohistochemistry using polyclonal rabbit anti-AQP3 antibody. Percentage of positive cells and staining intensity were counted and measured. Results The frequency of AQP3 positivity was similar between the disease types of chronic gastritis, gastric ulcer, gastric erosion, and atrophic gastritis, whereas the frequency of AQP3 positivity was significantly higher in patients with gastric intestinal metaplasia、gastric dysplasia 、gastric polyps and intestinal-type gastric adenocarcinoma than that in patients with gastritis, gastric ulcer, gastric erosion, or atrophic gastritis(p<0.0001, p=0.001, p=0.006, p=0.0009, respectively), especially in the patients with hyperplastic polyps (p<0.0001). Conclusion The frequency of AQP3 positivity was significantly higher in patients with gastric intestinal metaplasia, gastric dysplasia, and gastric adenocarcinoma, and the frequency between them was similar, suggesting that AQP3 expression is peaked at the stage of gastric intestinal metaplasia, which further confirmed that gastric intestinal metaplasia is a pivotal progression in gastric carcinogenesis pathologically. Interestingly, it is the first time to report AQP3 positive expression in patients with gastric polyps. In short, AQP3 is involved in the progression from gastritis to gastric adenocarcinoma, and might be a potential biomarker to improve the treatment strategy of gastric cancer.

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