Comparison of Immune Microenvironment Between Colon and Liver Metastatic Tissue in Colon Cancer Patients with Liver Metastasis

2020 ◽  
Author(s):  
Su-Na Zhou ◽  
Wen-Tao Pan ◽  
Meng-Xian Pan ◽  
Qiu-Yun Luo ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Immune Microenvironment ◽  
Metastatic Tissue

scholarly journals Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2418
Author(s):  
Xuezhen Zeng ◽  
Simon E. Ward ◽  
Jingying Zhou ◽  
Alfred S. L. Cheng
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
High Recurrence Rate ◽  
Immune Microenvironment ◽  
Liver Sinusoidal Endothelial Cells ◽  
Premetastatic Niche ◽  
Cancer Pathogenesis ◽  
Colorectal Cancer Patients ◽  
The Impact

A drastic difference exists between the 5-year survival rates of colorectal cancer patients with localized cancer and distal organ metastasis. The liver is the most favorable organ for cancer metastases from the colorectum. Beyond the liver-colon anatomic relationship, emerging evidence highlights the impact of liver immune microenvironment on colorectal liver metastasis. Prior to cancer cell dissemination, hepatocytes secrete multiple factors to recruit or activate immune cells and stromal cells in the liver to form a favorable premetastatic niche. The liver-resident cells including Kupffer cells, hepatic stellate cells, and liver-sinusoidal endothelial cells are co-opted by the recruited cells, such as myeloid-derived suppressor cells and tumor-associated macrophages, to establish an immunosuppressive liver microenvironment suitable for tumor cell colonization and outgrowth. Current treatments including radical surgery, systemic therapy, and localized therapy have only achieved good clinical outcomes in a minority of colorectal cancer patients with liver metastasis, which is further hampered by high recurrence rate. Better understanding of the mechanisms governing the metastasis-prone liver immune microenvironment should open new immuno-oncology avenues for liver metastasis intervention.

scholarly journals Alteration in the immune microenvironment based on APC status in MSS/pMMR colon cancer data retrieved from TCGA

2020 ◽  
Author(s):  
Haishan Lin ◽  
Hongchao Zhen ◽  
Kun Shan ◽  
Xiaoting Ma ◽  
Bangwei Cao
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Enrichment Analysis ◽  
Tumor Immunotherapy ◽  
Immune Checkpoints ◽  
Immune Microenvironment ◽  
Cancer Data ◽  
T Cell Infiltration ◽  
Colon Cancers ◽  
Tumor Immune Microenvironment

Abstract Immunotherapy is currently the most advanced anti-tumor treatment approach. The efficacy of anti-tumor immunotherapy is closely related to the tumor immune microenvironment, including immune cells, infiltration of immune factors, and expression of immune checkpoints. At present, the biomarkers for predicting the efficacy of colon cancer immunotherapy do not cover all colon cancer patients suitable for immunotherapy. In this study, TCGA database was used to identify tumor genotypes suitable for anti-tumor immunotherapy. We found that some of the MSS/pMMR populations, that were initially considered unsuitable for immunotherapy, might actually be suitable. In APC-wt/MSS colon cancer, the expression of PD-1, PD-L1, CTLA4 and CYT（GZMA and PRF1）were increased. Based on calculations done by ESTIMATE and CIBERSORT algorithms, the ImmunoScore and the proportion of CT8+ T cell infiltration is increased in these patients. Enrichment analysis was done to screen signaling pathways involved in immune response, extracellular matrix, and cell adhesion. Tumors from 42 colon cancer patients, including 22 APC-mt/MSS and 20 APC-wt/MSS, were immunohistochemically evaluated for expression of CD8 and PD-L1. And APC-wt/MSS tumors showed significantly higher expression of CD8 and PD-L1 than APC-mt/MSS tumor. Based on the results, we found that some colon cancers of APC-wt/MSS are classified by Tumor Immune Microenvironment types (TIMTs) TMIT I. So that we speculate that APC-wt/MSS colon cancer patients could benefit from anti-tumor immunotherapy.

scholarly journals Analysis of multi-omics differences in left-side and right-side colon cancer

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11433
Author(s):  
Yanyi Huang ◽  
Jinzhong Duanmu ◽  
Yushu Liu ◽  
Mengyun Yan ◽  
Taiyuan Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Gene Mutation ◽  
Somatic Mutation ◽  
Transcriptome Data ◽  
Characteristic Analysis ◽  
Immune Microenvironment ◽  
Mutation Data ◽  
Upregulated Genes ◽  
Testing Set

Background Colon cancer is one of the most common tumors in the digestive tract. Studies of left-side colon cancer (LCC) and right-side colon cancer (RCC) show that these two subtypes have different prognoses, outcomes, and clinical responses to chemotherapy. Therefore, a better understanding of the importance of the clinical classifications of the anatomic subtypes of colon cancer is needed. Methods We collected colon cancer patients’ transcriptome data, clinical information, and somatic mutation data from the Cancer Genome Atlas (TCGA) database portal. The transcriptome data were taken from 390 colon cancer patients (172 LCC samples and 218 RCC samples); the somatic mutation data included 142 LCC samples and 187 RCC samples. We compared the expression and prognostic differences of LCC and RCC by conducting a multi-omics analysis of each using the clinical characteristics, immune microenvironment, transcriptomic differences, and mutation differences. The prognostic signatures was validated using the internal testing set, complete set, and external testing set (GSE39582). We also verified the independent prognostic value of the signature. Results The results of our clinical characteristic analysis showed that RCC had a significantly worse prognosis than LCC. The analysis of the immune microenvironment showed that immune infiltration was more common in RCC than LCC. The results of differential gene analysis showed that there were 360 differentially expressed genes, with 142 upregulated genes in LCC and 218 upregulated genes in RCC. The mutation frequency of RCC was generally higher than that of LCC. BRAF and KRAS gene mutations were the dominant genes mutations in RCC, and they had a strong mutual exclusion with APC, while APC gene mutation was the dominant gene mutation in LCC. This suggests that the molecular mechanisms of RCC and LCC differed. The 4-mRNA and 6-mRNA in the prognostic signatures of LCC and RCC, respectively, were highly predictive and may be used as independent prognostic factors. Conclusion The clinical classification of the anatomic subtypes of colon cancer is of great significance for early diagnosis and prognostic risk assessment. Our study provides directions for individualized treatment of left and right colon cancer.

Transient elastography for the assessment of oxaliplatin-associated liver damage in colon cancer patients with liver metastasis.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e14088-e14088
Author(s):  
E. Oki ◽  
Y. Kakeji ◽  
M. Morita ◽  
Y. Emi ◽  
A. Taketomi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Liver Damage ◽  
Transient Elastography

Analysis of multi-omics differences in left-side and right-side colon cancer

2020 ◽  
Author(s):  
Yanyi Huang ◽  
Jinzhong Duanmu ◽  
Yushu Liu ◽  
Mengyun Yan ◽  
Taiyuan Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Somatic Mutation ◽  
Clinical Characteristics ◽  
Transcriptome Data ◽  
Clinical Classification ◽  
Immune Microenvironment ◽  
Mutation Data ◽  
Testing Set

Abstract Background:Colon cancer is one of the common tumors of digestive tract. Studies of left-side colon cancer(LCC) and right-side colon cancer(RCC) show that these two subtypes had different prognosis, outcomes, and clinical response to chemotherapy. Therefore,it is necessary to explore the necessity of clinical classification of anatomic subtypes about colon cancer.Methods:We selected the transcriptome data, clinical information and somatic mutation data of colon cancer patients from the the Cancer Genome Atlas(TCGA )database portal.The transcriptome data included 390 colon cancer patients(172 LCC samples and 218 RCC samples),and the somatic mutation data included 142 LCC samples and 187 RCC samples.By conducting a multi-omics analysis of the LCC and RCC from the four aspects of clinical characteristics, immune microenvironment , transcriptomic differences and mutation differences, so as to compare the expression and prognosis difference of LCC and RCC.We are the first to construct prognostic signatures respectively for LCC and RCC respectively.The prognostic signatures is validated by internal testing set, complete set and external testing set(GSE39582).Additionally we also verified the independent prognostic value of the signature.Results:Clinical characteristics analysis results show that RCC had a significantly worse prognosis than LCC.Analysis the immune microenvironment analysis shows that RCC was more immune infiltration than LCC.The results of differential gene analysis showed that there were 360 differential expressed genes,with 142 up genes in LCC and 218 up genes in RCC.Correlation analysis of mutated genes showed that the expression of mutated genes in RCC was negatively correlated, while the expression of mutated genes in LCC was positively correlated, and the mutation frequency of RCC was generally higher than that of LCC.Meanwhile, our 4-mRNA LCC and 6-mRNA RCC prognostic signatures are highly predictive and can be used as independent prognostic factors.Conclusion:The clinical classification of anatomic subtypes of colon cancer is of great significance for its early diagnosis and prognostic risk assessment.Our study provides directions for individualized treatment of left and right colon cancer.

Overexpression of PTGIS Could Predict Liver Metastasis and is Correlated with Poor Prognosis in Colon Cancer Patients

2011 ◽  
Vol 18 (3) ◽  
pp. 563-569 ◽  
Author(s):  
Sun Lichao ◽  
Peng Liang ◽  
Guo Chunguang ◽  
Lv Fang ◽  
Yang Zhihua ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Poor Prognosis

scholarly journals Fusobacteria is Associated with a Th1 and Th17 Immune Microenvironment in Colon Cancer Patients and Germ‐Free Mice

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Jada C Domingue ◽  
Julia L Drewes ◽  
Susan Bullman ◽  
Alina Corona ◽  
Christina DeStefano Shields ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Immune Microenvironment ◽  
Germ Free

Alteration in the Immune Microenvironment Based on APC Status in MSS/pMMR Colon Cancer Data Retrieved from TCGA

2021 ◽  
Author(s):  
Haishan Lin ◽  
Nina Ma ◽  
Hongchao Zhen ◽  
Kun Shang ◽  
Xiaoting Ma ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Enrichment Analysis ◽  
Tumor Immunotherapy ◽  
Immune Checkpoints ◽  
Sequencing Data ◽  
Immune Microenvironment ◽  
Cancer Data ◽  
Colon Cancers ◽  
Tumor Immune Microenvironment

Abstract BackgroundImmunotherapy is currently the most advanced anti-tumor treatment approach. The efficacy of anti-tumor immunotherapy is closely related to the tumor immune microenvironment, including immune cells, infiltration of immune factors, and expression of immune checkpoints. At present, the biomarkers for predicting the efficacy of colon cancer immunotherapy do not cover all colon cancer patients suitable for immunotherapy. In this study, TCGA database was used to identify tumor genotypes suitable for anti-tumor immunotherapy. MethodsWe downloaded 390 samples with RNA-sequencing data and somatic mutation status data from TCGA. We applied the ESTIMATE, Package limma, the CIBERSORT and some other algorithms to analyze the cellular immune microenvironment. And validated with immunohistochemistry in tumor tissues of colon cancer patients. ResultsWe found that some of the MSS/pMMR populations, that were initially considered unsuitable for immunotherapy, might actually be suitable. In APC-wt/MSS colon cancer, the expression of PD-1, PD-L1, CTLA4 and CYT（GZMA and PRF1）were increased. Based on calculations done by ESTIMATE and CIBERSORT algorithms, the ImmunoScore and the proportion of CT8+ T cell infiltration is increased in these patients. Enrichment analysis was done to screen signaling pathways involved in immune response, extracellular matrix, and cell adhesion. Tumors from 42 colon cancer patients, including 22 APC-mt/MSS and 20 APC-wt/MSS, were immunohistochemically evaluated for expression of CD8 and PD-L1. And APC-wt/MSS tumors showed significantly higher expression of CD8 and PD-L1 than APC-mt/MSS tumor. ConclusionsBased on the results, we found that some colon cancers of APC-wt/MSS are classified by Tumor Immune Microenvironment types (TIMTs) TMIT I. So that we speculate that APC-wt/MSS colon cancer patients could benefit from anti-tumor immunotherapy.

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