scholarly journals Power of a reproducing kernel-based method for testing the joint effect of a set of single-nucleotide polymorphisms

Genetica ◽  
2012 ◽  
Vol 140 (10-12) ◽  
pp. 421-427 ◽  
Author(s):  
Hong He ◽  
Hongmei Zhang ◽  
Arnab Maity ◽  
Yubo Zou ◽  
James Hussey ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Reproducing Kernel ◽  
Joint Effect ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Unified variable selection in semi-parametric models

2015 ◽  
Vol 26 (6) ◽  
pp. 2821-2831 ◽  
Author(s):  
William Terry ◽  
Hongmei Zhang ◽  
Arnab Maity ◽  
Hasan Arshad ◽  
Wilfried Karmaus
Keyword(s):  
Dna Methylation ◽  
Single Nucleotide Polymorphisms ◽  
Variable Selection ◽  
Reproducing Kernel ◽  
Allergic Sensitization ◽  
Joint Effect ◽  
Bayesian Variable Selection ◽  
Parametric Models ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

We propose a Bayesian variable selection method in semi-parametric models with applications to genetic and epigenetic data (e.g., single nucleotide polymorphisms and DNA methylation, respectively). The data are individually standardized to reduce heterogeneity and facilitate simultaneous selection of categorical (single nucleotide polymorphisms) and continuous (DNA methylation) variables. The Gaussian reproducing kernel is applied to the transformed data to evaluate joint effect of the variables, which may include complex interactions between, e.g., single nucleotide polymorphisms and DNA methylation. Indicator variables are introduced to the model for the purpose of variable selection. The method is demonstrated and evaluated using simulations under different scenarios. We apply the method to identify informative DNA methylation sites and single nucleotide polymorphisms in a set of genes based on their joint effect on allergic sensitization. The selected single nucleotide polymorphisms and methylation sites have the potential to serve as early markers for allergy prediction, and consequently benefit medical and clinical research to prevent allergy before its manifestation.

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide

Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

2007 ◽  
Vol 28 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Rosalind Arden ◽  
Nicole Harlaar ◽  
Robert Plomin
Keyword(s):  
Sex Differences ◽  
Single Nucleotide Polymorphisms ◽  
Cognitive Ability ◽  
Dna Markers ◽  
Community Sample ◽  
Nucleotide Polymorphisms ◽  
General Cognitive Ability ◽  
Single Nucleotide ◽  
The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

Sign in / Sign up

Export Citation Format

Share Document