Evaluation of the effect of smokeless tobacco (Maras powder) on choroidal and retinal blood flow: an optical coherence tomography angiography study

Purpose. To study retinal blood flow in pregnant women with diabetes using optical coherence tomography angiography (OCTA). Material and methods. 60 pregnant women were examined: 24 women had type 1 and 2 diabetes (T1D and T2D) and 36 healthy women with physiological pregnancy consisted the control group. Pregnant women with diabetes were examined in three trimesters of pregnancy, the control group – in the third trimester. OCTA imaging was performed using the RTVue XR Avanti OCT 6×6 mm Angio Retina scan protocols (Optovue, USA). The vascular density (VD), vascular density in the fovea (VDF), and foveal avascular zone (FAZ) area in the superficial capillary plexus were studied. Results. In the third trimester, VDF in pregnant women with diabetes was significantly less than in the control group, in the absence of differences in VD and FAZ area. VD was significantly lower, and FAZ area was significantly higher in pregnant women with diabetic retinopathy (DR) than in pregnant women with diabetes without DR. There were no significant differences in the values of blood flow parameters in the groups of pregnant women with diabetes, regardless of underwent them the laser coagulation of the retina. At analyzing the values of VD, VDF, FAZ area in pregnant women with diabetes in different trimesters of pregnancy, statistically significant differences were not observed. In 11 pregnant women with DR areas of retinal nonperfusion were revealed, which in 6 patients tended to expand during pregnancy. In 2 patients with T1D without DR in the third trimester areas of nonperfusion were identified. Conclusion. Obtained data have practical importance for the diagnosis of DR manifestations during pregnancy. OCTA is a valuable diagnostic method that allows non-invasive diagnostics of the presence of areas of retinal nonperfusion in the absence of ophthalmoscopic signs of DR in pregnant women with diabetes, as well as assess the state of areas of retinal nonperfusion during pregnancy in patients with DR. Key words: optical coherence tomography angiography, diabetic retinopathy, pregnancy.

Download Full-text

Visualization of three-dimensional microcirculation of rodents’ retina and choroid for studies of critical illness using optical coherence tomography angiography

Scientific Reports ◽

10.1038/s41598-021-93631-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jang Ryul Park ◽

ByungKun Lee ◽

Min Ji Lee ◽

Kyuseok Kim ◽

Wang-Yuhl Oh

Keyword(s):

Blood Flow ◽

Optical Coherence Tomography ◽

Severe Sepsis ◽

Critical Illness ◽

Hemorrhagic Shock ◽

Optical Coherence Tomography Angiography ◽

Flow Index ◽

Optical Coherence ◽

Sepsis Model ◽

Lactate Levels

AbstractWe developed a method to measure the relative blood flow speed using optical coherence tomography angiography (OCTA) in retina and choroid, and investigated the feasibility of this method for assessing microcirculatory function in rat models of sepsis and hemorrhagic shock. Two sepsis models, 6-h severe sepsis without treatment and 30-h moderate sepsis maintaining mean arterial pressure, and volume controlled hemorrhagic shock and fluid resuscitation model were used to see the change of microcirculation. The blood flow index (BFI), which was calculated from the OCTA images to represent the average relative blood flow, was decreasing during the 6-h severe sepsis model. Its change is in parallel with the mean arterial blood pressure (MAP) and blood lactate levels. In the 30-h moderate sepsis model, the BFI was decreased while maintaining MAP, and lactate was increased. In the hemorrhagic shock model, the change of BFI is in line with MAP and lactate levels. In all models, BFI change is more sensitive in choroid than in retina. This study presents the OCTA-based retinal and choroidal microcirculatory blood flow monitoring method and shows its utility for assessment of critical illness.

Download Full-text

En faceDoppler total retinal blood flow measurement with 70 kHz spectral optical coherence tomography

Journal of Biomedical Optics ◽

10.1117/1.jbo.20.6.066004 ◽

2015 ◽

Vol 20 (6) ◽

pp. 066004 ◽

Cited By ~ 16

Author(s):

Ou Tan ◽

Gangjun Liu ◽

Liu Liang ◽

Simon S. Gao ◽

Alex D. Pechauer ◽

...

Keyword(s):

Blood Flow ◽

Optical Coherence Tomography ◽

Flow Measurement ◽

Retinal Blood Flow ◽

Blood Flow Measurement ◽

Optical Coherence ◽

Spectral Optical Coherence Tomography

Download Full-text

Retinal Blood Flow Response to Hyperoxia Measured With En Face Doppler Optical Coherence Tomography

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.15-18917 ◽

2016 ◽

Vol 57 (9) ◽

pp. OCT141 ◽

Cited By ~ 4

Author(s):

Alex D. Pechauer ◽

Ou Tan ◽

Liang Liu ◽

Yali Jia ◽

Vivian Hou ◽

...

Keyword(s):

Blood Flow ◽

Optical Coherence Tomography ◽

Retinal Blood Flow ◽

Optical Coherence ◽

Blood Flow Response ◽

Flow Response ◽

En Face ◽

Doppler Optical Coherence Tomography

Download Full-text

Investigation of Macular Choroidal Thickness and Blood Flow Change by Optical Coherence Tomography Angiography After Posterior Scleral Reinforcement

Frontiers in Medicine ◽

10.3389/fmed.2021.658259 ◽

2021 ◽

Vol 8 ◽

Author(s):

Zheng Zhang ◽

Yue Qi ◽

Wenbin Wei ◽

Zi-Bing Jin ◽

Wen Wang ◽

...

Keyword(s):

Blood Flow ◽

Optical Coherence Tomography ◽

High Myopia ◽

Choroidal Thickness ◽

Optical Coherence Tomography Angiography ◽

Pathologic Myopia ◽

Optical Coherence ◽

Short Period ◽

Posterior Scleral Reinforcement

Purpose: This work aimed to study the effect of posterior scleral reinforcement (PSR) on choroidal thickness (CT) and blood flow.Methods: This study included 25 eyes of 24 patients with high myopia ( ≤ -6.0 dioptres or axial length ≥ 26.0 mm) who underwent PSR surgery. All patients completed the 1-month follow-up visit. Myopic macular degeneration (MMD) was graded according to the International Meta-Analysis for Pathologic Myopia (META-PM) classification based on color fundus photographs. Swept-source optical coherence tomography angiography (SSOCTA) was performed to investigate CT, choroidal perfusion area (CPA), and choriocapillaris perfusion area (CCPA) change following PSR surgery.Results: The distribution of MMD categories was 9 (36.0%) in category 1, 10 (40.0%) in category 2, and 6 (24.0%) in category 3 or 4. MMD severity was strongly correlated with CT (all P < 0.01) and CPA (all P < 0.04). Postoperative CT at each sector increased significantly at 1 week's follow-up, compared to preoperative measures (all P < 0.05). Postoperative CPA at subfoveal, superior, inferior, and nasal sectors also increased significantly 1 week after PSR surgery (all P < 0.05). Moreover, the increased CT, CPA, and CCPA remain after PSR surgery at 1 month's follow-up, but the difference was not statistically significant.Conclusions: We demonstrated that the CT and choroidal blood flow increased significantly in patients with high myopia who underwent PSR surgery in a short period of time. In addition, the CT and CPA were independently associated with MMD. However, whether the transient improvement of the choroidal circulation could prevent long-term progression of high myopia warrants further study in the future.

Download Full-text

Assessment of choriocapillary blood flow changes in response to half-dose photodynamic therapy in chronic central serous chorioretinopathy using optical coherence tomography angiography

10.21203/rs.2.18778/v6 ◽

2020 ◽

Author(s):

Juejun Liu ◽

Changzheng Chen ◽

Lu Li ◽

Yishuang Xu ◽

Zuohuizi Yi ◽

...

Keyword(s):

Blood Flow ◽

Optical Coherence Tomography ◽

Photodynamic Therapy ◽

Central Serous Chorioretinopathy ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Chronic Central Serous Chorioretinopathy ◽

Half Dose ◽

Flow Changes

Abstract Background: Optical coherence tomography angiography (OCTA) is a newly developed imaging quantitative technique for analysis of choriocapillaris (CC) flow changes, thereby exploring the pathological mechanism of chronic central serous chorioretinopathy (CCSC) and the therapeutic effects of photodynamic therapy (PDT). In this study, we sought to quantify the blood flow changes in CC of CCSC patients receiving half-dose PDT using OCTA.Methods: A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled in this study. The proportion of total areas of flow signal voids (FSV, %) in CC level of OCTA was assessed in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition, the CC patterns in response to PDT at early stage and the subsequent morphologic changes were qualitatively documented using OCTA.Results: For affected eyes, FSV at 6-m follow-up was significantly lower than that at 1-m follow-up (p=0.036). When compared to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), and FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT were identified, including signs of recovery with more even flow signals, transient appearance of worse ischemia and secondary neovascularization within CC level.Conclusion: Abnormal CC flow attenuation remains in completely resolved eyes of CCSC patients treated with half-dose PDT.

Download Full-text