Urban and Education Disparity for Autism Spectrum Disorders in Taiwan Birth Cohort Study

2016 ◽  
Vol 47 (3) ◽  
pp. 599-606 ◽  
Author(s):  
For-Wey Lung ◽  
Tung-Liang Chiang ◽  
Shio-Jean Lin ◽  
Bih-Ching Shu
Keyword(s):  
Cohort Study ◽  
Autism Spectrum Disorders ◽  
Birth Cohort ◽  
Autism Spectrum ◽  
Birth Cohort Study ◽  
Spectrum Disorders ◽  
Taiwan Birth Cohort Study

Neonatal levels of cytokines and risk of autism spectrum disorders: An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank

2012 ◽  
Vol 252 (1-2) ◽  
pp. 75-82 ◽  
Author(s):  
Morsi W. Abdallah ◽  
Nanna Larsen ◽  
Erik L. Mortensen ◽  
Hjördis Ó. Atladóttir ◽  
Bent Nørgaard-Pedersen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Autism Spectrum Disorders ◽  
Newborn Screening ◽  
Birth Cohort ◽  
Autism Spectrum ◽  
Birth Cohort Study ◽  
Spectrum Disorders

scholarly journals Two-stage window screening and development trajectories in early identification of autism spectrum disorder among Han Chinese children

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
For-Wey Lung ◽  
Bih-Ching Shu
Keyword(s):  
Autism Spectrum Disorder ◽  
Cohort Study ◽  
Language Development ◽  
Birth Cohort ◽  
Screening Method ◽  
Autism Spectrum ◽  
Birth Cohort Study ◽  
Two Stage ◽  
Window Screening ◽  
Taiwan Birth Cohort Study

Abstract Objective An understanding of the trajectory and norm of development in children is needed in order to understand the concept of the spectrum in the diagnosis of autism spectrum disorder (ASD). Children’s developmental growth trajectory was measured from six to 66 months in the Taiwan Birth Cohort Study dataset (N = 11,145). Additionally, over 4 years of follow-up, the negative predictive value of using the Parental Concern Checklist and Taiwan Birth Cohort Study Developmental Instrument was also investigated as the first stage of screening in a two-stage window screening method for ASD diagnosis. Results The growth trajectory showed that children’s language development began to increase at 18 months, and peaked at 36 months. On the other hand, social development showed steady growth from 18 to 66 months. The increase in the trajectory of children’s language development prior to age three, when compared with other developmental dimensions, may increase the difficulty of diagnosing ASD. The two-stage window screening method can be used in settings where the screening sample is large, such as in community or primary care settings, and has been found to be time- and cost-efficient. Better understanding of children’s developmental trajectory can enhance detection and intervention for ASD.

scholarly journals Epidemiological and Serological Investigation into the Role of Gestational Maternal Influenza Virus Infection and Autism Spectrum Disorders

mSphere ◽  
2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Milada Mahic ◽  
Xiaoyu Che ◽  
Ezra Susser ◽  
Bruce Levin ◽  
Ted Reichborn-Kjennerud ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Autism Spectrum Disorders ◽  
Virus Infection ◽  
Birth Cohort ◽  
Influenza Virus Infection ◽  
Epidemiological Studies ◽  
Autism Spectrum ◽  
Positive Serology ◽  
Influenza Like Illness ◽  
Spectrum Disorders

ABSTRACT The causes of most cases of autism spectrum disorders (ASD) are unknown. Some epidemiological studies suggest that maternal gestational influenza virus infection may increase the risk of ASD in offspring. Here, we describe an analysis of a large birth cohort with results based on questionnaires that prospectively addressed subjective reports of influenza-like illness and serological assays for objective determination of influenza virus infection. Although serologic evidence of gestational influenza virus infection alone was not associated with risk, positive serology and symptoms of influenza-like illness cannot yet be definitely ruled out as a risk factor. The literature concerning gestational maternal influenza virus infection and risk of autism spectrum disorders (ASD) is inconclusive. To address this uncertainty, we obtained information from questionnaires and samples from the Autism Birth Cohort, a prospective birth cohort comprising mothers, fathers, and offspring recruited in Norway in 1999 to 2008. Through questionnaires, referrals, and linkages to the Norwegian National Patient Registry, we identified 338 mothers of children with ASD and 348 frequency-matched controls for whom plasma samples that had been collected midpregnancy and after delivery were available for influenza virus serology via luciferase immunoprecipitation and hemagglutinin inhibition assays for influenza virus strains circulating during the study period. Assay data were combined to define serological status and integrated with self-reports of influenza-like illness to estimate ASD risk. Neither influenza A nor influenza B virus infection was associated with increased ASD risk. Integration of reports of symptoms of influenza-like illness with serology revealed an increase in risk for seropositive women with symptoms, but this increase did not achieve statistical significance (a level of P < 0.05) in the comparison with seronegative women without symptoms (adjusted odds ratio, 1.93; 95% confidence interval, 0.95 to 3.89; P = 0.068). Although chance may explain our findings, the magnitude of the potential association may be of biological importance, and dismissing our findings could result in failure to detect a bona fide association (type II error). If the association is true, we posit that the risk is due to activation of the maternal immune system following infection rather than direct fetal infection. Data on levels of cytokines or other mediators of inflammation would allow us to test the validity of this hypothesis. IMPORTANCE The causes of most cases of autism spectrum disorders (ASD) are unknown. Some epidemiological studies suggest that maternal gestational influenza virus infection may increase the risk of ASD in offspring. Here, we describe an analysis of a large birth cohort with results based on questionnaires that prospectively addressed subjective reports of influenza-like illness and serological assays for objective determination of influenza virus infection. Although serologic evidence of gestational influenza virus infection alone was not associated with risk, positive serology and symptoms of influenza-like illness cannot yet be definitely ruled out as a risk factor.

scholarly journals Association between maternal shift work and infant neurodevelopmental outcomes: results from the Taiwan Birth Cohort Study with propensity-score-matching analysis

2019 ◽  
Vol 48 (5) ◽  
pp. 1545-1555
Author(s):  
Chih-Fu Wei ◽  
Mei-Huei Chen ◽  
Ching-Chun Lin ◽  
Yueliang Leon Guo ◽  
Shio-Jean Lin ◽  
...  
Keyword(s):  
Cohort Study ◽  
Propensity Score ◽  
Birth Cohort ◽  
Shift Work ◽  
Fine Motor ◽  
Birth Cohort Study ◽  
Work Status ◽  
Neurodevelopmental Outcomes ◽  
Gross Motor ◽  
Taiwan Birth Cohort Study

Abstract Background Maternal shift work is associated with preterm delivery, small-for-gestational-age new-borns, childhood obesity and future behavioural problems. However, the adverse effects on and interactions of maternal shift work with infant neurodevelopment remain uncertain. Therefore, we examined the associations between maternal-shift-work status and infant neurodevelopmental parameters. Methods The Taiwan Birth Cohort Study is a nationwide birth cohort study following representatively sampled mother–infant pairs in 2005. The participants’ development and exposure conditions were assessed by home interviews with structured questionnaires at 6 and 18 months of age. Propensity scores were calculated with predefined covariates for 1:1 matching. Multivariate conditional logistic regression and the Cox proportional-hazards model were used to examine the association between maternal-shift-work status and infant neurodevelopmental-milestone-achievement status. Results In this study, 5637 term singletons were included, with 2098 cases selected in the propensity-score-matched subpopulation. Persistent maternal shift work was associated with increased risks of delays in gross-motor neurodevelopmental milestones [aOR = 1.36, 95% confidence interval (CI) = 1.06–1.76 for walking steadily], fine-motor neurodevelopmental milestones (aOR = 1.39, 95% CI = 1.07–1.80 for scribbling) and social neurodevelopmental milestones (aOR = 1.35, 95% CI = 1.03–1.76 for coming when called upon). Moreover, delayed gross-motor and social development were identified in the propensity-score-matched sub-cohort. Conclusions This study shows negative associations between maternal shift work and delayed neurodevelopmental-milestone achievement in the gross-motor, fine-motor and social domains at 18 months. Future research is necessary to elucidate the possible underlying mechanisms and long-term health effects.

scholarly journals From dissociative experience and internet use to happiness: A Taiwan Birth Cohort Study

2020 ◽  
Author(s):  
For-Wey Lung ◽  
Bih-Ching Shu ◽  
Tung-Liang Chiang ◽  
Shio-Jean Lin
Keyword(s):  
Cohort Study ◽  
Protective Factors ◽  
Birth Cohort ◽  
Internet Use ◽  
Depressive Mood ◽  
High Risk Group ◽  
Birth Cohort Study ◽  
Self Identity ◽  
Study Results ◽  
Taiwan Birth Cohort Study

Abstract Background Functional and excessive use of internet is hard to distinguish, and internet use can affect adolescents’ development of self-identity. The aim of our study was to investigate the pathway relationship of the risk and protective factors of internet use, including mother care, absorptive dissociative trait, having been bullied, exercise, self-perceived depressive mood and happiness of 12-year-old adolescents. Methods The Taiwan Birth Cohort Study dataset, which used a national household probability sampling method and included 17,694 12-years-old adolescents, was used for this study. Results Our results showed 5.3% adolescents reported to spend more than five hours online during schooldays. Additionally, adolescents that spend more than five hours online during schooldays tended to have higher absorptive trait, perceived less care from mothers, more likely to have been bullied, expressed higher level of depressed mood, which leads to lower level of perceived happiness. Conclusions Adolescents that spend more than 5 hours online during schooldays, compared to those that spent less than an hour online, were more likely to have been bullied and affect their level of happiness, showing that they may be a group of higher concern. Since parental care and regular exercise are protective factors for internet addiction, it should be promoted to all adolescents, especially those in the high risk group, to prevent them from being addicted online.

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