Association between maternal shift work and infant neurodevelopmental outcomes: results from the Taiwan Birth Cohort Study with propensity-score-matching analysis

Abstract Background Maternal shift work is associated with preterm delivery, small-for-gestational-age new-borns, childhood obesity and future behavioural problems. However, the adverse effects on and interactions of maternal shift work with infant neurodevelopment remain uncertain. Therefore, we examined the associations between maternal-shift-work status and infant neurodevelopmental parameters. Methods The Taiwan Birth Cohort Study is a nationwide birth cohort study following representatively sampled mother–infant pairs in 2005. The participants’ development and exposure conditions were assessed by home interviews with structured questionnaires at 6 and 18 months of age. Propensity scores were calculated with predefined covariates for 1:1 matching. Multivariate conditional logistic regression and the Cox proportional-hazards model were used to examine the association between maternal-shift-work status and infant neurodevelopmental-milestone-achievement status. Results In this study, 5637 term singletons were included, with 2098 cases selected in the propensity-score-matched subpopulation. Persistent maternal shift work was associated with increased risks of delays in gross-motor neurodevelopmental milestones [aOR = 1.36, 95% confidence interval (CI) = 1.06–1.76 for walking steadily], fine-motor neurodevelopmental milestones (aOR = 1.39, 95% CI = 1.07–1.80 for scribbling) and social neurodevelopmental milestones (aOR = 1.35, 95% CI = 1.03–1.76 for coming when called upon). Moreover, delayed gross-motor and social development were identified in the propensity-score-matched sub-cohort. Conclusions This study shows negative associations between maternal shift work and delayed neurodevelopmental-milestone achievement in the gross-motor, fine-motor and social domains at 18 months. Future research is necessary to elucidate the possible underlying mechanisms and long-term health effects.

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Household incense burning and infant gross motor development: Results from the Taiwan Birth Cohort Study

Environment International ◽

10.1016/j.envint.2018.03.005 ◽

2018 ◽

Vol 115 ◽

pp. 110-116 ◽

Cited By ~ 9

Author(s):

Chih-Fu Wei ◽

Mei-Huei Chen ◽

Ching-Chun Lin ◽

Yueliang Leon Guo ◽

Shio-Jean Lin ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Motor Development ◽

Birth Cohort Study ◽

Gross Motor ◽

Gross Motor Development ◽

Incense Burning ◽

Taiwan Birth Cohort Study

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Associations between Household Incense Burning and Motor Development of Preterm Infants: Results from the Taiwan Birth Cohort Study with Propensity Score Weighting Analysis

SSRN Electronic Journal ◽

10.2139/ssrn.3436304 ◽

2019 ◽

Author(s):

Chih-Fu Wei ◽

Ching-Chun Lin ◽

Meng-Shan Tsai ◽

Yueliang Leon Guo ◽

Shio-Jean Lin ◽

...

Keyword(s):

Cohort Study ◽

Propensity Score ◽

Birth Cohort ◽

Preterm Infants ◽

Motor Development ◽

Birth Cohort Study ◽

Propensity Score Weighting ◽

Incense Burning ◽

Taiwan Birth Cohort Study

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218 Maternal shift work during pregnancy and infant neurodevelopment parameters at eighteen months: results from taiwan birth cohort study

10.1136/oemed-2018-icohabstracts.409 ◽

2018 ◽

Author(s):

Chihfu Wei ◽

Pau-Chung Chen

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Shift Work ◽

Birth Cohort Study ◽

Infant Neurodevelopment ◽

Taiwan Birth Cohort Study

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Diarrheal Pathogens Associated with Growth and Neurodevelopment

Clinical Infectious Diseases ◽

10.1093/cid/ciaa1938 ◽

2021 ◽

Author(s):

Jeffrey R Donowitz ◽

Jeannie Drew ◽

Mami Taniuchi ◽

James A Platts-Mills ◽

Masud Alam ◽

...

Keyword(s):

Cohort Study ◽

Socioeconomic Factors ◽

Birth Cohort ◽

Linear Growth ◽

Attributable Fraction ◽

Birth Cohort Study ◽

Neurodevelopmental Outcomes ◽

Typical Epec ◽

Toddler Development ◽

Pathogen Burden

Abstract Background Diarrheal pathogens have been associated with linear growth deficits. The effect of diarrheal pathogens on growth is likely due to inflammation which also adversely affects neurodevelopment. We hypothesized that diarrheagenic pathogens would be negatively associated with both growth and neurodevelopment. Methods We conducted a longitudinal birth cohort study of 250 children with diarrheal surveillance and measured pathogen burden in diarrheal samples using quantitative PCR. Pathogen attributable fraction estimates (AFe) of diarrhea over the first two years of life, corrected for socioeconomic variables, were used to predict both growth and scores on the Bayley III Scales of Infant and Toddler Development. Results 180 children were analyzed for growth and 162 for neurodevelopmental outcomes. Rotavirus, Campylobacter, and Shigella were the leading causes of diarrhea in year 1 while Shigella, Campylobacter, and ST-ETEC were the leading causes in year 2. Norovirus was the only pathogen associated with LAZ at 24 months and was positively associated (RC 0.42, CI 0.04, 0.80). Norovirus (RC 2.46, CI 0.05 – 4.87) was also positively associated with cognitive scores while sapovirus (RC -2.64, CI -4.80 – -0.48) and Typical EPEC (RC -4.14, CI -8.02 – -0.27) were inversely associated. No pathogens were associated with language or motor scores. Significant maternal, socioeconomic, and perinatal predictors were identified for both growth and neurodevelopment. Conclusion Maternal, prenatal, and socioeconomic factors were common predictors of growth and neurodevelopment. Only a limited number of diarrheal pathogens were associated with these outcomes.

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Maternal Glycemia during pregnancy and Early Offspring Development: A Prospective Birth Cohort Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab331 ◽

2021 ◽

Author(s):

Peng Wang ◽

Jun Xie ◽

Xue-chun Jiao ◽

Shuang-shuang Ma ◽

Yang Liu ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Plasma Glucose ◽

Birth Cohort Study ◽

Neurodevelopmental Outcomes ◽

Glucose Levels ◽

Maternal Glucose Levels ◽

Prospective Birth Cohort ◽

Maternal Glucose ◽

Prospective Birth Cohort Study

Abstract Context The association of maternal gestational diabetes mellitus (GDM) with neurodevelopmental outcomes remains controversial and evidence that maternal increasing levels of glucose during pregnancy associated with the risk for impaired neurodevelopment were limited. Objective To identify the continuous association of increasing maternal glucose levels with neurodevelopmental disorders in offspring and explore the potential contribution of cord metabolites to this association. Methods The prospective birth cohort study included 1036 mother-child pairs. Primary predictors were maternal exposure GDM and maternal glucose values at a 75-g oral-glucose-tolerance test (OGTT) at 24–28 weeks during pregnancy. Primary neurodevelopmental outcomes at 12 mo in offspring were assessed by the ASQ-3. Results Maternal GDM was associated with failing the communication domain in offspring in the adjusted models [RR with 95% CI: 1.97(1.11, 3.52)]. Increasing levels of fasting plasma glucose (FPG), 1 h plasma glucose (1-h PG) and 2 h plasma glucose (2-h PG) with one SD change were at higher risks in failing the personal social domain of ASQ [RRs with 95% CI for FPG: 1.49(1.09, 2.04); for 1-h PG: 1.70(1.27, 2.29); for 2-h PG: 1.36(1.01, 1.84)]. The linear association was also demonstrated. Compared with girls, boys exposed to higher maternal glucose levels were inclined to the failure of the personal social domain. Mediation analysis showed the contribution of maternal GDM to failure of communication domain mediated by C-peptide. Conclusions Maternal glucose levels below those diagnostic of diabetes are continuously associated with impaired neurodevelopment in offspring at 12 mo.

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From dissociative experience and internet use to happiness: A Taiwan Birth Cohort Study

10.21203/rs.3.rs-32607/v1 ◽

2020 ◽

Author(s):

For-Wey Lung ◽

Bih-Ching Shu ◽

Tung-Liang Chiang ◽

Shio-Jean Lin

Keyword(s):

Cohort Study ◽

Protective Factors ◽

Birth Cohort ◽

Internet Use ◽

Depressive Mood ◽

High Risk Group ◽

Birth Cohort Study ◽

Self Identity ◽

Study Results ◽

Taiwan Birth Cohort Study

Abstract Background Functional and excessive use of internet is hard to distinguish, and internet use can affect adolescents’ development of self-identity. The aim of our study was to investigate the pathway relationship of the risk and protective factors of internet use, including mother care, absorptive dissociative trait, having been bullied, exercise, self-perceived depressive mood and happiness of 12-year-old adolescents. Methods The Taiwan Birth Cohort Study dataset, which used a national household probability sampling method and included 17,694 12-years-old adolescents, was used for this study. Results Our results showed 5.3% adolescents reported to spend more than five hours online during schooldays. Additionally, adolescents that spend more than five hours online during schooldays tended to have higher absorptive trait, perceived less care from mothers, more likely to have been bullied, expressed higher level of depressed mood, which leads to lower level of perceived happiness. Conclusions Adolescents that spend more than 5 hours online during schooldays, compared to those that spent less than an hour online, were more likely to have been bullied and affect their level of happiness, showing that they may be a group of higher concern. Since parental care and regular exercise are protective factors for internet addiction, it should be promoted to all adolescents, especially those in the high risk group, to prevent them from being addicted online.

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