Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?

Abstract Background：Previous studies have shown that in young women, single blastocyst transfer can achieve satisfactory pregnancy results, but there are few studies on the difference between fresh and frozen-thawed single blastocyst transfer. In this retrospective analysis, the purpose of this study was to compare the pregnancy outcomes of young patients who received fresh or frozen-thawed single blastocyst transfer, so as to provide further clinical strategies for single blastocyst transfer.Methods: A retrospective analysis of patients aged ≤35 years old undergoing single blastocyst transfer was performed from January 2018 to December 2018 in the reproductive center of the Second Affiliated Hospital of Wenzhou Medical University. A total of 901 patients were involved and were divided into two groups according to the type of transfer cycle, 693 of which were in the fresh embryo transfer cycle (group A) and 208 of which were in the frozen-thawed embryo transfer cycle (group B). The laboratory and pregnancy outcomes were compared between the groups. Results：The number of oocytes retrieved in group B was significantly more than in group A ( P＜0.05). The early miscarriage rate in group B was higher than in group A, with significant difference(P＜0.05). There were no significant differences in other basic conditions and obstetric pregnancy outcomes between the two groups.Conclusions：Favorable pregnancy outcomes could be obtained in both fresh and frozen-thawed single blastocyst transfer in young patients without increasing the birth defect rate. For patients with risk factors of OHSS such as more oocyte retrieval, ovarian hyper-response, or risk factors of ectopic pregnancy such tubal infertility and the history of ectopic pregnancy, frozen-thawed single blastocyst transfer could be highly recommended in clinical practice. However, since the early miscarriage rate is higher in frozen-thawed embryo transfer group, further research is needed to figure out the cause and possible solutions.

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A Validated Model for Individualized Prediction of Live Birth in Patients With Adenomyosis Undergoing Frozen-Thawed Embryo Transfer

10.21203/rs.3.rs-842214/v1 ◽

2021 ◽

Author(s):

Yaoqiu Wu ◽

Rong Yang ◽

Jie Lan ◽

Haiyan Lin ◽

Chunwei Cao ◽

...

Keyword(s):

Confidence Interval ◽

Embryo Transfer ◽

Live Birth ◽

Twin Pregnancy ◽

Blastocyst Transfer ◽

Specific Information ◽

Training Cohort ◽

Uterine Volume ◽

Frozen Thawed Embryo Transfer ◽

Thawed Embryo Transfer

Abstract Background There is few predictive tools for live birth in women with adenomyosis, which provide further personalized and clinically specific information related to individualized decisions making during IVF/ICSI treatment. Methods A total of 424 patients with adenomyosis underwent frozen-thawed embryo transfer (FET) from Jan 2013 to Dec 2019 at a public university hospital were included. The patients were randomly divided into training (n = 265) and validation (n = 159) samples for the building and testing of the nomogram, respectively. Multivariate logistic regression (MLR) was developed on the basis of clinical covariates assessed for their association with live birth. Results In all, 183 (43.16%) patients became pregnant, and 114 (26.88%) had a live birth. In the multivariable analysis of the training cohort, probability of live birth was significantly correlated with the age < 37 years old (odds ratio [OR], 3.465; 95% CI, 1.215–9.885, P = 0.020), uterine volume prior ET < 102.02 cm3 (OR, 8.141; 95% CI, 2.170–10.542; P = 0.002), blastocyst transfer (OR, 3.231; 95% CI, 1.065–8.819, P = 0.023), twin pregnancy (OR, 0.328; 95% CI, 0.104–0.344, P = 0.005) and protocol in FET (P < 0.001). The statistical nomogram was built based on the five variates, age, uterine volume prior embryo transfer, twin pregnancy, stage of transferred embryo and protocol of FET, with an area under the curve (AUC) of 0.837 (95% confidence interval: 0.741–0.910) for the training cohort. The AUC for the validation cohort was 0.737 (95% confidence interval: 0.661–0.813), showing a satisfactory goodness-of-fit and discrimination ability in this nomogram. Conclusions Single blastocyst transfer, GnRH-a pretreated and smaller uterine size before embryo transfer contributed to increasing live birth rate in patients with adenomyosis. The user-friendly nomogram built on the risk factors of live birth in patients with adenomyosis, provides a useful guide for medical staff on individualized decisions making during the IVF/ICSI procedure.

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Comparison of birthweights in patients randomly assigned to fresh or frozen-thawed embryo transfer

10.26226/morressier.573c1513d462b80296c98a23 ◽

2016 ◽

Author(s):

Bruce Shapiro

Keyword(s):

Embryo Transfer ◽

Frozen Thawed Embryo Transfer ◽

Thawed Embryo Transfer

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THE EFFECT OF ASSISTED HATCHING IN FROZEN-THAWED EMBRYO TRANSFER CYCLES

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2016.3.12 ◽

2016 ◽

pp. 80-84

Author(s):

Thi Tam An Nguyen ◽

Minh Tam Le ◽

Ngoc Thanh Cao

Keyword(s):

Embryo Transfer ◽

Zona Pellucida ◽

Assisted Hatching ◽

Implantation Failure ◽

Multiple Pregnancies ◽

Recurrent Implantation Failure ◽

Key Words Laser ◽

Implantation And Pregnancy Rates ◽

Frozen Thawed Embryo Transfer ◽

Thawed Embryo Transfer

Background: Laser assisted hatching technique based on the hypothesis to make an artificial hole on zona pellucida (ZP) that can help embryo hatching out of ZP easily. This technique has been shown to increase implantation and pregnancy rates in women of advanced age, in women with recurrent implantation failure and following the transfer of frozen–thawed embryos. This study described the outcome of frozen–thawed embryo transfers with laser assisted hatching (LAH), which is one of the safest method in nowadays. Purpose: To assess the effect of assisted hatching technique on the clinical outcomes in vitrified-warmed transfer cycles. Method: A total of 65 thawed-transfer cycles with 153 thawed-embryos undertaken within a 12-month period were analysed, Assisted hatching with laser zona thinning was performed with one-quarter of the zona pellucida circumference. The overall thawed-embryos (day 3) were kept in culture overnight. Patient were prepared the suitable endometrium and transferred embryos advantageously. Results: In which, having the rate of survival embryos were 143 occupying 94.3%, the percentage of grade 1 and 2 embryos occupied 55.9% and 29,3% respectively, and that were enrolled LAH before transfering of frozen–thawed embryos. The average transferred embryos were 2.4±0.8, The rate of implantation per transferred embryos and per transferred embryos cycles was 19.5% and 43.1% respectively. The rate of clinical pregnancies per embryo transfer cycles occupied 33.8% with percentage of early miscarriages (biochemical pregnancies and early clinical miscarriages) was 12.3%. The rate of ongoing pregnancies was 30.8% and multiple pregnancies was low just 12.3%. This result was equal or higher than other researchs in embryos transfer had or no LAH. Conclusion: LAH contributed to stable frozen–thawed embryos transfer effectiveness. Key words: Laser assisted hatching, frozen–thawed embryos transfer, zona pellucida (ZP)

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