The Nsun7 (A11337)-deletion mutation, causes reduction of its protein rate and associated with sperm motility defect in infertile men

Abstract Objective Evaluate the effects of vitamin D3 (VD3) on sperm parameters and endocrine markers in infertile men with asthenozoospermia. Materials and methods This randomized, triple-masking, placebo-controlled clinical trial conducted on 86 asthenozoospermia infertile men with serum 25 hydroxy vitamin D3 (25(OH)VD3) < 30 ng/ml in the infertility clinic of Ahvaz Jahad daneshgahi, Iran. Patients were randomly allocated to groups A and B, who received daily 4000 IU VD3 and matching placebo respectively for 3 months. Demographic data, dietary intake, physical activity, sun exposure, anthropometric indices, serum 25(OH)VD3, luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), estradiol (E2),, sex hormone-binding globulin (SHBG), free androgen index (FAI = T/SHBG. 100), T/LH and T/E2 ratios, prolactin (PRO), parathyroid hormone (PTH), osteocalcin (OCN), phosphorus and sperm parameters were assessed. Results Three months VD3 supplementation with 4000 IU/day had no significant effects body weight, body mass index (BMI), waist circumference (WC), body fat (BF), serum, OCN, LH, FSH, T, E2, SHBG, PRO, T/E2 ratio, FAI, semen volume, sperm count and normal sperm morphology. It increases serum 25(OH)VD3, PTH and phosphorus and seminal and serum calcium, T/LH ratio and total and progressive sperm motility and decreased significantly compared to the baseline and placebo group. Conclusion VD3 supplementation may affect sperm motility in men with asthenozoospermia and serum 25(OH)VD3 < 30 ng/ml. Trial registration Iran Clinical Trials Registry, ID: IRCT20151128025274N4, registered on 28 March 2018, URL of trial registry record: https://www.irct.ir/trial/29983

Download Full-text

Seminal cytology in infertile men with chlamydia trachomatis and ureaplasma urealyticum infections. observations through electron microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100166336 ◽

1996 ◽

Vol 54 ◽

pp. 774-775

Author(s):

M. G. Gallegos A. ◽

O. G. Díaz G. ◽

M. J. Vazquez H. ◽

R. Rositas M. ◽

E. Ramirez B.

Keyword(s):

Electron Microscopy ◽

Fine Structure ◽

Chlamydia Trachomatis ◽

Sperm Motility ◽

Ureaplasma Urealyticum ◽

Sperm Quality ◽

Sexual Contact ◽

Infertile Men ◽

Asymptomatic Infections

Among non gonococcic uretritis 60 % of them are caused by C. trachomatis and U. urealyticum, organisms transmited by sexual contact. These are frecuently presented like asymptomatic infections and involved a diminish sperm quality. The defects in motility and morphology of spermatozoa associated with these infections have not to date been explained clearly, although, in the case of U. urealyticum it has been shown that sperm motility is decreased by the physical adherence of the organism to the tail of the spermatozoon.Although, some descriptions of the ultraestructure of semen in pacients with U. urealyticum and C trachomatis infections exist, there has not been a detailed description of alterations of the fine structure of the spermatozoa that can or can't be related to astenozoospermia.

Download Full-text