Embryo banking among women diagnosed with cancer: a pilot population-based study in New York, Texas, and Illinois

Objective.To examine the incidence of gout over the last 20 years and to evaluate possible changes in associated comorbid conditions.Methods.The medical records were reviewed of all adults with a diagnosis of incident gout in Olmsted County, Minnesota, USA, during 2 time periods (January 1, 1989–December 31, 1992, and January 1, 2009–December 31, 2010). Incident cases had to fulfill at least 1 of 3 criteria: the American Rheumatism Association 1977 preliminary criteria for gout, the Rome criteria, or the New York criteria.Results.A total of 158 patients with new-onset gout were identified during 1989–1992 and 271 patients during 2009–2010, yielding age- and sex-adjusted incidence rates of 66.6/100,000 (95% CI 55.9–77.4) in 1989–1992 and 136.7/100,000 (95% CI 120.4–153.1) in 2009–2010. The incidence rate ratio was 2.62 (95% CI 1.80–3.83). At the time of their first gout flare, patients diagnosed with gout in 2009–2010 had higher prevalence of comorbid conditions compared with 1989–1992, including hypertension (69% vs 54%), diabetes mellitus (25% vs 6%), renal disease (28% vs 11%), hyperlipidemia (61% vs 21%), and morbid obesity (body mass index ≥ 35 kg/m2; 29% vs 10%).Conclusion.The incidence of gout has more than doubled over the recent 20 years. This increase together with the more frequent occurrence of comorbid conditions and cardiovascular risk factors represents a significant public health challenge.

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Incidence of Spondyloarthropathy in Patients with Ulcerative Colitis: A Population-based Study

The Journal of Rheumatology ◽

10.3899/jrheum.121029 ◽

2013 ◽

Vol 40 (7) ◽

pp. 1153-1157 ◽

Cited By ~ 17

Author(s):

Raina Shivashankar ◽

Edward V. Loftus ◽

William J. Tremaine ◽

W. Scott Harmsen ◽

Alan R. Zinsmeister ◽

...

Keyword(s):

Ulcerative Colitis ◽

New York ◽

Cumulative Incidence ◽

Population Based ◽

Olmsted County ◽

Extraintestinal Manifestation ◽

Population Based Study ◽

Time Period ◽

Asas Criteria ◽

Inflammatory Bowel

Objective.Spondyloarthritis (SpA) is an important extraintestinal manifestation of inflammatory bowel disease (IBD). We assessed the cumulative incidence and clinical spectrum of SpA in a population-based cohort of patients with ulcerative colitis (UC).Methods.The medical records of a population-based cohort of residents of Olmsted County, Minnesota, USA, diagnosed with UC from 1970 through 2004 were reviewed. Patients were followed longitudinally until moving from Olmsted County, death, or June 30, 2011. We used the European Spondylarthropathy Study Group, Assessment of Spondyloarthritis International Society (ASAS) criteria, and modified New York criteria to identify patients with SpA.Results.The cohort included 365 patients with UC, of whom 41.9% were women. The median age at diagnosis of UC was 38.6 years (range 1.2–91.4). Forty patients developed SpA based on the ASAS criteria. The cumulative incidence of a diagnosis of SpA after an established diagnosis of UC was 4.8% at 10 years (95% CI 95% CI 2.2%–7.3%), 13.7% at 20 years (95% CI 9.0%–18.1%), and 22.1% at 30 years (95% CI 4.3%–29.1%).Conclusion.The cumulative incidence of all forms of SpA increased to about 22% by 30 years from UC diagnosis. This value is slightly greater than what we previously described in a population-based cohort of Crohn disease diagnosed in Olmsted County over the same time period. SpA and its features are associated with UC, and heightened awareness on the part of clinicians is needed for diagnosing and managing them.

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Changes in the Presentation of Incident Gout and the Risk of Subsequent Flares: A Population-based Study over 20 Years

The Journal of Rheumatology ◽

10.3899/jrheum.190346 ◽

2019 ◽

Vol 47 (4) ◽

pp. 613-618 ◽

Cited By ~ 2

Author(s):

Mohanad M. Elfishawi ◽

Nour Zleik ◽

Zoran Kvrgic ◽

Clement J. Michet ◽

Cynthia S. Crowson ◽

...

Keyword(s):

New York ◽

Kidney Disease ◽

Cumulative Incidence ◽

Population Based ◽

Rome Criteria ◽

Population Based Study ◽

American Rheumatism Association ◽

The Mean ◽

Incident Cases ◽

Gout Flares

Objective.To examine whether a change in the presentation of incident gout happened over the last 20 years and to determine the risk of subsequent gout flares after an initial gout attack.Methods.All incident cases of gout were identified among residents of Olmsted County, Minnesota, diagnosed in 1989–1992 and 2009–2010 according to the earliest date fulfilling the 1977 American Rheumatism Association preliminary criteria, or the New York or Rome criteria for gout. Patients in both cohorts were then followed for up to 5 years. Cumulative incidence and person-year methods were used to compare flare rates, and conditional frailty models were used to examine predictors.Results.A total of 429 patients with incident gout (158 patients in 1989–1992 and 271 patients in 2009–2010) were identified and followed for a mean of 4.2 years. The majority of patients were male (73%) and the mean age (SD) at gout onset was 59.7 (17.3) years. Classic podagra decreased significantly from 74% to 59% (p < 0.001). Cumulative incidence of first flare was similar in both cohorts (62% vs 60% by 5 yrs in 1989–1992 and 2009–2010, respectively; p = 0.70), but overall flare rate was marginally higher in 2009–2010 compared to 1989–1992 (rate ratio: 1.24). Hyperuricemia (HR 1.59) and kidney disease (HR 1.34) were significant predictors of future flares.Conclusion.Gout flares were common in both time periods. Hyperuricemia and kidney disease were predictors of future flares in patients with gout. Podagra as a presentation of gout has become relatively less frequent in recent years.

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