Guidelines informing counseling on female age-related fertility decline: a systematic review

Background/Objective:: The aim of this systematic review is to identify all the available data on human lens proteomics with a critical role to age-related cataract formation in order to elucidate the physiopathology of the aging lens. Materials and Methods:: We searched on Medline and Cochrane databases. The search generated 328 manuscripts. We included nine original proteomic studies that investigated human cataractous lenses. Results:: Deamidation was the major age-related post-translational modification. There was a significant increase in the amount of αA-crystallin D-isoAsp58 present at all ages, while an increase in the extent of Trp oxidation was apparent in cataract lenses when compared to aged normal lenses. During aging, enzymes with oxidized cysteine at critical sites included GAPDH, glutathione synthase, aldehyde dehydrogenase, sorbitol dehydrogenase, and PARK7. Conclusion:: D-isoAsp in αA crystallin could be associated with the development of age-related cataract in human, by contributing to the denaturation of a crystallin, and decreasing its ability to act as a chaperone. Oxidation of Trp may be associated with nuclear cataract formation in human, while the role of oxidant stress in age-related cataract formation is dominant.

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A systematic review of dermal fillers for age-related lines and wrinkles

ANZ Journal of Surgery ◽

10.1111/j.1445-2197.2010.05351.x ◽

2011 ◽

Vol 81 (1-2) ◽

pp. 9-17 ◽

Cited By ~ 8

Author(s):

Lana P. Sturm ◽

Rodney D. Cooter ◽

Keith L. Mutimer ◽

John C. Graham ◽

Guy J. Maddern

Keyword(s):

Systematic Review ◽

Dermal Fillers ◽

Age Related

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Decision regret and associated factors following oocyte cryopreservation in patients with diminished ovarian reserve and/or age-related fertility decline

Journal of Assisted Reproduction and Genetics ◽

10.1007/s10815-021-02164-7 ◽

2021 ◽

Author(s):

Aysen Gurbuz ◽

Aylin Pelin Cil ◽

Lale Suzan Karakis ◽

Remzi Abali ◽

Mehmet Ceyhan ◽

...

Keyword(s):

Ovarian Reserve ◽

Fertility Decline ◽

Associated Factors ◽

Diminished Ovarian Reserve ◽

Oocyte Cryopreservation ◽

Decision Regret ◽

Age Related

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Obesity and risk of age-related eye diseases: a systematic review of prospective population-based studies

International Journal of Obesity ◽

10.1038/s41366-021-00829-y ◽

2021 ◽

Author(s):

Clarissa Ng Yin Ling ◽

Su Chi Lim ◽

Jost B. Jonas ◽

Charumathi Sabanayagam

Keyword(s):

Systematic Review ◽

Population Based ◽

Eye Diseases ◽

Age Related

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Carotenoids in the Management of Glaucoma: A Systematic Review of the Evidence

Nutrients ◽

10.3390/nu13061949 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1949

Author(s):

Drake W. Lem ◽

Dennis L. Gierhart ◽

Pinakin Gunvant Davey

Keyword(s):

Systematic Review ◽

Tissue Injury ◽

Open Angle Glaucoma ◽

Synaptic Activity ◽

Antioxidant Defenses ◽

Cochrane Library ◽

Retinal Ganglion ◽

Age Related ◽

Retinal Ganglion Cell Survival ◽

Oxidative Insult

Primary open-angle glaucoma (POAG) remains a leading cause of irreversible blindness globally. Recent evidence further substantiates sustained oxidative stress, and compromised antioxidant defenses are key drivers in the onset of glaucomatous neurodegeneration. Overwhelming oxidative injury is likely attributed to compounding mitochondrial dysfunction that worsens with age-related processes, causing aberrant formation of free radical species. Thus, a compromised systemic antioxidant capacity exacerbates further oxidative insult in glaucoma, leading to apoptosis, neuroinflammation, and subsequent tissue injury. The purpose of this systematic review is to investigate the neuroprotective benefits of the macular carotenoids lutein, zeaxanthin, and meso-zeaxanthin on glaucomatous neurodegeneration for the purpose of adjunctive nutraceutical treatment in glaucoma. A comprehensive literature search was conducted in three databases (PubMed, Cochrane Library, and Web of Science) and 20 records were identified for screening. Lutein demonstrated enhanced neuroprotection on retinal ganglion cell survival and preserved synaptic activity. In clinical studies, a protective trend was seen with greater dietary consumption of carotenoids and risk of glaucoma, while greater carotenoid levels in macular pigment were largely associated with improved visual performance in glaucomatous eyes. The data suggest that carotenoid vitamin therapy exerts synergic neuroprotective benefits and has the capacity to serve adjunctive therapy in the management of glaucoma.

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The Association Between Sarcopenia and Postoperative Outcomes Among Older Adults With Hip Fracture: A Systematic Review

Journal of Applied Gerontology ◽

10.1177/07334648211006519 ◽

2021 ◽

pp. 073346482110065

Author(s):

Ming-Hsiu Chiang ◽

Yi-Jie Kuo ◽

Yu-Pin Chen

Keyword(s):

Systematic Review ◽

Older Adults ◽

Hip Fracture ◽

Postoperative Mortality ◽

Clinical Event ◽

High Morbidity ◽

Adverse Health Outcomes ◽

Age Related ◽

Study Selection ◽

And Function

Hip fracture is a serious clinical event with high morbidity and mortality. Sarcopenia is characterized by age-related loss of muscle mass and function, leading to several adverse health outcomes. In this systematic review, no limitation criteria were used for study selection and 327 studies were identified in the initial search. Of these, 11 studies comprising a total of 2,314 patients were selected. The overall proportion of older adults with hip fracture having sarcopenia was 44%, with a disparity of approximately 10% between men and women. Most studies have indicated that older adults with sarcopenia had poorer postoperative functional recovery than those without sarcopenia; the association between sarcopenia and high postoperative mortality or long hospital stay was heterogeneous. Well-organized studies with longer follow-up periods are warranted.

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