Decision regret and associated factors following oocyte cryopreservation in patients with diminished ovarian reserve and/or age-related fertility decline

2021 ◽  
Author(s):  
Aysen Gurbuz ◽  
Aylin Pelin Cil ◽  
Lale Suzan Karakis ◽  
Remzi Abali ◽  
Mehmet Ceyhan ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Fertility Decline ◽  
Associated Factors ◽  
Diminished Ovarian Reserve ◽  
Oocyte Cryopreservation ◽  
Decision Regret ◽  
Age Related

scholarly journals Elective oocyte cryopreservation for age-related fertility decline

2021 ◽  
Author(s):  
E. Chronopoulou ◽  
C. Raperport ◽  
A. Sfakianakis ◽  
G. Srivastava ◽  
R. Homburg
Keyword(s):  
Fertility Decline ◽  
Oocyte Cryopreservation ◽  
Age Related ◽  
Elective Oocyte Cryopreservation

P–698 Antimüllerian Hormone (AMH) value as a predictive marker of cycle ploidy outcome

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
A Arnanz ◽  
I Elkhatib ◽  
A Bayram ◽  
A El-Damen ◽  
A Abdala ◽  
...  
Keyword(s):  
Oocyte Maturation ◽  
Ovarian Reserve ◽  
Reference Group ◽  
Predictive Marker ◽  
Ovarian Response ◽  
Diminished Ovarian Reserve ◽  
Developmental Competence ◽  
Preimplantation Genetic Testing ◽  
Final Oocyte Maturation ◽  
Age Related

Abstract Study question Do woman with diminished ovarian reserve exhibit poor blastocyst formation and ploidy outcomes, irrespective of age? Summary answer Patients with extreme diminished ovarian reserve (AMH≤0.65ng/ml) have a lower chance to have at least one euploid blastocyst compared to their age-related reference population (AMH=1.3–6.25ng/ml). What is known already AMH is an established marker of the ovarian reserve for predicting ovarian response to ovarian stimulation and it is strongly correlated with female age. However, it has been suggested that AMH is not only a quantitative, but also a qualitative biomarker of oocyte/embryo competence. Previous studies show conflicting outcomes as to whether reduced ovarian reserve per se is associated with decreased oocyte developmental competence, leading to increased aneuploidy rates in embryos independent of the patient’s age. Study design, size, duration A retrospective analysis was performed between March 2017 and July 2020 at ART Fertility Clinics (Abu Dhabi) including all couples that were triggered for final oocyte maturation and planned for Preimplantation Genetic Testing for Aneuploidies (PGT-A). Patients were stratified into four age categories [≤30, 31–35, 36–40, >40 years]. For each age category patients were further divided into three AMH groups: ≤0.65ng/ml, 0.65–1.3ng/ml and 1.31–6.25ng/ml (reference group). Participants/materials, setting, methods Trophectoderm biopsy samples were subjected to Next Generation Sequencing. AMH serum levels (ng/ml) were determined using the commercial fully automated Elecsys® (Roche) assay. Patients with a Progesterone rise of > 1.5ng/ml on the day of final oocyte maturation and patients with AMH values >6.25ng/ml were excluded from the analysis. Per patient that was triggered, the chance to have at least one euploid blastocyst in that cycle, was calculated. Main results and the role of chance A total of 1.300 couples were included with an mean maternal age of 35.6±6.2 years, AMH of 2.1 ±1.5ng/ml and body mass index of 27.5±5.0 kg/m2. The chance to have at least one blastocyst biopsied per cycle was affected in all patients with extreme low AMH (≤0.65ng/ml), irrespective of age; ≤30 years: 58.33%–100.00%–94.84% (p < 0.001); 31–35 years: 50.00%–74.55%–95.32% (p < 0.001); 36–40 years: 56.52%–81.93%–92.56% (p < 0.001) and ≥40 years: 38.06%–73.02%–88.24% (p < 0.001), for AMH ≤0.65ng/ml, 0.65–1.3ng/ml and 1.31–6.25ng/ml, respectively. In all age categories, patients with AMH values ≤0.65ng/ml had a significantly reduced probability of having a euploid blastocyst compared to the reference group (1.31–6.25ng/ml). For women ≤30 years the chances of getting a euploid blastocyst decreased from 88.89% (n = 252) to 41.67% (n = 12) (OR 0.01 [0.03–0.30], p < 0.001), for 31–35 years from 88.09% (n = 235) to 43.75% (n = 32) (OR 0.10 [0.05–0.23], p < 0.001), for 36–40 years from 77.67% (n = 215) to 21.74% (n = 69) (OR 0.08 [0.04–0.15], p < 0.001) and among women >40 years from 29.42% (n = 102) to 6.45% (n = 155) (OR 0.16 [0.08–0–36], p < 0.001). Woman within AMH range of 0.65–1.3ng/ml presented the same decreased probability of having a euploid blastocyst only when 31–35 (52.73%, n = 55) or 36–40 years old (56.63%, n = 83) (OR 0.15 [0.08–0.29], p < 0.001 and OR 0.37 [0.22–0.64], p < 0.001, respectively). Limitations, reasons for caution The main limitation of this study is its retrospective design. Wider implications of the findings: AMH is a clear biomarker of oocyte-embryo competence. Incorporation of AMH-specific counseling recommendations into clinical practice guidelines, could lead to a more informed guidance on cycle ploidy outcomes, rather than age alone. Trial registration number Not applicable

MicroRNAs with Altered Expression Profiles in Granulosa of Women of Advanced Age with Diminished Ovarian Reserve

2020 ◽  
Vol 10 (10) ◽  
pp. 2316-2323
Author(s):  
Danqi Liu ◽  
Fang Lian ◽  
Shan Xiang ◽  
Ying Guo ◽  
Haicui Wu ◽  
...  
Keyword(s):  
Young Women ◽  
Ovarian Reserve ◽  
Target Genes ◽  
Expression Profiles ◽  
Micro Rna ◽  
Diminished Ovarian Reserve ◽  
Advanced Age ◽  
Altered Expression ◽  
Age Related ◽  
Microrna Sequencing

Objective: The objective of this study was to investigate the micro-RNA differences between women of advanced age with a diminished ovarian reserve (DOR) and young women with a normal ovarian reserve (NOR), and the causes leading to the decline of ovarian reserve function and oocyte function in women, which may be related to aging. Methods: The prospective cohort investigation method was used in this study. We used microRNA sequencing to detect the microRNA expression profiles for women of advanced age with DOR function and young women with NOR function. Then, the differentially expressed microRNAs were compared and the agerelated mechanism was predicted by the target genes. Results: The microRNA sequencing results revealed that 70 microRNA expressions were different, including 45 downregulated expressions and 25 upregulated expressions. Specifically, miR-221-3p, miR-146b-5p, miR-378a-3p, miR-143-5p, miR-222-5p, and miR-221-5p were significantly downregulated; miR-6881-3p, miR-4787-3p, miR-4745-5p, miR-6513-3p, and miR-3179 were upregulated. The primary pathways are PI3K-Akt, MAPK, Phospholipase D, and Chemokine. Conclusions: Differences were observed between the expression profiles of microRNAs in the granulosa cells of the ovaries of patients with DOR and NOR. These differences may be age-related.

Age-Related Decline in DNA Repair Function Explains Diminished Ovarian Reserve, Earlier Menopause, and Possible Oocyte Vulnerability to Chemotherapy in Women With BRCA Mutations

2014 ◽  
Vol 32 (10) ◽  
pp. 1093-1094 ◽  
Author(s):  
Kutluk Oktay ◽  
Fred Moy ◽  
Shiny Titus ◽  
Robert Stobezki ◽  
Volkan Turan ◽  
...  
Keyword(s):  
Dna Repair ◽  
Ovarian Reserve ◽  
Diminished Ovarian Reserve ◽  
Brca Mutations ◽  
Age Related

P-202 Diminished ovarian reserve in women with advanced endometriosis

1997 ◽  
Vol 68 ◽  
pp. S188-S189
Author(s):  
D.L Hock ◽  
L.S Dagostino ◽  
E Kemmann
Keyword(s):  
Ovarian Reserve ◽  
Diminished Ovarian Reserve

Implications of diminished ovarian reserve (DOR) extend well beyond reproductive concerns

2008 ◽  
Vol 15 (6) ◽  
pp. 1086-1094 ◽  
Author(s):  
Lubna Pal ◽  
Kris Bevilacqua ◽  
Gohar Zeitlian ◽  
Jun Shu ◽  
Nanette Santoro
Keyword(s):  
Ovarian Reserve ◽  
Diminished Ovarian Reserve ◽  
Reproductive Concerns
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