In vitro drug release study of methacrylate polymer blend system: effect of polymer blend composition, drug loading and solubilizing surfactants on drug release

2009 ◽  
Vol 21 (2) ◽  
pp. 583-588 ◽  
Author(s):  
Jun Li ◽  
David Barrow ◽  
Holly Howell ◽  
Sid Kalachandra
Keyword(s):  
Drug Release ◽  
Polymer Blend ◽  
Drug Loading ◽  
System Effect ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Blend Composition ◽  
Release Study

scholarly journals PREPARATION AND CHARACTERIZATION OF TRIFLUOPERAZINE LOADED TRANSDERMAL PATCHES FOR SUSTAINED RELEASE

2021 ◽  
pp. 186-191
Author(s):  
ANJU PARAMBIL ◽  
SEENIVASAN PALANICHAMY ◽  
ARUL KUTTALINGAM ◽  
VELLAPANDIAN CHITRA
Keyword(s):  
Drug Release ◽  
Ethyl Cellulose ◽  
Drug Loading ◽  
Polymeric Matrix ◽  
Infrared Spectroscopic Study ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Folding Endurance ◽  
Release Study

Objective: The purpose of the present study was to formulate and evaluate the polymeric transdermal delivery system of antipsychotic drug Trifluoperazine (TFP) for sustained drug release. Methods: A transdermal patch loaded with (TFP) was formulated by solvent casting technique. Polyvinyl pyrrolidone (PVP) K-30 and ethyl cellulose (EC) was used as a polymeric matrix with different ratios. Di n-butyl phthalate was used as a plasticizer. The parameters such as thickness, folding endurance and weight variation of the prepared patches were studied. The interaction study by attenuated total reflectance-infrared (ATR-IR) spectroscopy, X-ray diffraction and thermal analysis by differential scanning calorimetry (DSC) were performed. In vitro drug release study was performed by modified paddle over-disc technique. Results: The infrared spectroscopic study confirmed the absence of any chemical interaction between TFP and selected polymers. All the prepared formulations showed folding endurance values ranging from 130-162 and a satisfactory drug loading of 90-95%. In in vitro drug release study, formulations PE-3 and PE-4 exhibited a sustained and stable cumulative release of 54 % and 48% respectively, at the end of 24 h. The DSC and XRD analysis proved the partial conversion of the drug from crystalline to amorphous form when integrated into the polymeric matrix. Conclusion: The prepared transdermal formulations using polymers PVP and ethyl cellulose demonstrated their ability to sustain the release of TFP. The developed formulation could be exploited for multiday therapy of TFP for the effective treatment of schizophrenia with a simplified dosing regimen and enhanced patient compliance.

Formulation and Evaluation of Transdermal patch of Methimazole

2021 ◽  
pp. 4667-4672
Author(s):  
Nani Tadhi ◽  
Himansu Chopra ◽  
Gyanendra Kumar Sharma
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Transdermal Patch ◽  
Formulation Development ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Percent Moisture ◽  
Release Study

Transdermal patch is a drug delivery device in which the drugs are incorporated and is design in such a way that it releases the drug in sustained and at predetermined rate to deliver the drug through the skin to the systemic circulation painlessly. The aim of this research study was to formulate a controlled and sustained release transdermal matrix type patch of Methimazole. The matrix patch was prepared by solvent casting method using a various polymer in different concentration, HPMC (hydrophilic), Eudragit RL100 and Ethyl cellulose (hydrophobic) polymer. Total 9 prototype formulation were prepared and it was subjected for various evaluation test; weight uniformity, Folding endurance, thickness, Drug content, percent moisture content, percent Moisture uptake and In-vitro drug release study using Franz diffusion cell. The in-vitro CDR% data was fit into kinetics model to see the release kinetics from the patches. The Formulation F5 was choosen as a best formulation according to in-vitro drug release study. The in-vitro release was found 81.12 % in 12 hours, it followed zero order kinetics. The nature of polymer and concentration ratio of polymers plays a crucial role for obtaining a good transdermal patch design; therefore optimisation is very important step to formulate a desired TDDS. Therefore the result of the study encourages a further study and is hopeful that the present study would contribute to the recent pharmaceutical research for formulation development.

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES OF NICERGOLINE FOR BUCCAL DRUG DELIVERY BY USING FACTORIAL DESIGN OF EXPERIMENT (DOE)

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (07) ◽  
pp. 52-57
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Design Of Experiment ◽  
Release Profile ◽  
Drug Release Profile ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Drug Content ◽  
Release Study

The aim of this research was to develop mucoadhesive buccal patches of nicergoline by using Factorial Design of Experiment, in order to provide a sustained release of drug into the systemic circulation. A 33 factorial experimental design was employed for optimization and to study the effect of formulation variables on responses R1 (% swelling index), R2 (% drug content), R3 (mucoadhesion time) and R4 (mucoadhesion strength). In vitro drug release study was performed on the optimized formulations. All the prepared formulations had good mechanical strength, mucoadhesion strength, neutral surface pH and drug content up to 98.17%. In vitro drug release study revealed that F-5 formulation showed promising sustained drug release profile (98.21%) for over 8 h and could be a potential substitute for marketed conventional formulations. The developed formulation (F5) was found to be optimized with considerably good stability and extended drug release profile.

scholarly journals Plant-mediated biosynthesis of zein–pectin nanoparticle: Preparation, characterization and in vitro drug release study

2020 ◽  
Vol 32 (2) ◽  
pp. 1785-1791
Author(s):  
Dhanya Arambath Thankappan ◽  
Haridas Karickal Raman ◽  
Joby Jose ◽  
Sudheesh Sudhakaran
Keyword(s):  
Drug Release ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Nanoparticle Preparation ◽  
Release Study

Hydrogel containing dexamethasone-loaded nanocapsules for cutaneous administration: preparation, characterization, and in vitro drug release study

2010 ◽  
Vol 36 (8) ◽  
pp. 962-971 ◽  
Author(s):  
M.L. Marchiori ◽  
G. Lubini ◽  
G. Dalla Nora ◽  
R.B. Friedrich ◽  
M.C. Fontana ◽  
...  
Keyword(s):  
Drug Release ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Release Study ◽  
Cutaneous Administration
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