Radiation Synthesis of Magnesium Doped Nano Hydroxyapatite/(Acacia-Gelatin) Scaffold for Bone Tissue Regeneration: In Vitro Drug Release Study

2019 ◽  
Vol 30 (8) ◽  
pp. 2890-2906
Author(s):  
Amany I. Raafat ◽  
H. Kamal ◽  
Hayat M. Sharada ◽  
Sawsan A. Abd elhalim ◽  
Randa D. Mohamed
Keyword(s):  
Drug Release ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
In Vitro Drug Release ◽  
Radiation Synthesis ◽  
Drug Release Study ◽  
Regeneration In Vitro ◽  
Release Study

Formulation and Evaluation of Transdermal patch of Methimazole

2021 ◽  
pp. 4667-4672
Author(s):  
Nani Tadhi ◽  
Himansu Chopra ◽  
Gyanendra Kumar Sharma
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Transdermal Patch ◽  
Formulation Development ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Percent Moisture ◽  
Release Study

Transdermal patch is a drug delivery device in which the drugs are incorporated and is design in such a way that it releases the drug in sustained and at predetermined rate to deliver the drug through the skin to the systemic circulation painlessly. The aim of this research study was to formulate a controlled and sustained release transdermal matrix type patch of Methimazole. The matrix patch was prepared by solvent casting method using a various polymer in different concentration, HPMC (hydrophilic), Eudragit RL100 and Ethyl cellulose (hydrophobic) polymer. Total 9 prototype formulation were prepared and it was subjected for various evaluation test; weight uniformity, Folding endurance, thickness, Drug content, percent moisture content, percent Moisture uptake and In-vitro drug release study using Franz diffusion cell. The in-vitro CDR% data was fit into kinetics model to see the release kinetics from the patches. The Formulation F5 was choosen as a best formulation according to in-vitro drug release study. The in-vitro release was found 81.12 % in 12 hours, it followed zero order kinetics. The nature of polymer and concentration ratio of polymers plays a crucial role for obtaining a good transdermal patch design; therefore optimisation is very important step to formulate a desired TDDS. Therefore the result of the study encourages a further study and is hopeful that the present study would contribute to the recent pharmaceutical research for formulation development.

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES OF NICERGOLINE FOR BUCCAL DRUG DELIVERY BY USING FACTORIAL DESIGN OF EXPERIMENT (DOE)

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (07) ◽  
pp. 52-57
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Design Of Experiment ◽  
Release Profile ◽  
Drug Release Profile ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Drug Content ◽  
Release Study

The aim of this research was to develop mucoadhesive buccal patches of nicergoline by using Factorial Design of Experiment, in order to provide a sustained release of drug into the systemic circulation. A 33 factorial experimental design was employed for optimization and to study the effect of formulation variables on responses R1 (% swelling index), R2 (% drug content), R3 (mucoadhesion time) and R4 (mucoadhesion strength). In vitro drug release study was performed on the optimized formulations. All the prepared formulations had good mechanical strength, mucoadhesion strength, neutral surface pH and drug content up to 98.17%. In vitro drug release study revealed that F-5 formulation showed promising sustained drug release profile (98.21%) for over 8 h and could be a potential substitute for marketed conventional formulations. The developed formulation (F5) was found to be optimized with considerably good stability and extended drug release profile.

scholarly journals Plant-mediated biosynthesis of zein–pectin nanoparticle: Preparation, characterization and in vitro drug release study

2020 ◽  
Vol 32 (2) ◽  
pp. 1785-1791
Author(s):  
Dhanya Arambath Thankappan ◽  
Haridas Karickal Raman ◽  
Joby Jose ◽  
Sudheesh Sudhakaran
Keyword(s):  
Drug Release ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Nanoparticle Preparation ◽  
Release Study

Hydrogel containing dexamethasone-loaded nanocapsules for cutaneous administration: preparation, characterization, and in vitro drug release study

2010 ◽  
Vol 36 (8) ◽  
pp. 962-971 ◽  
Author(s):  
M.L. Marchiori ◽  
G. Lubini ◽  
G. Dalla Nora ◽  
R.B. Friedrich ◽  
M.C. Fontana ◽  
...  
Keyword(s):  
Drug Release ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Release Study ◽  
Cutaneous Administration

Scaffolds containing chitosan, gelatin and graphene oxide for bone tissue regeneration in vitro and in vivo

2017 ◽  
Vol 104 ◽  
pp. 1975-1985 ◽  
Author(s):  
S. Saravanan ◽  
Anjali Chawla ◽  
M. Vairamani ◽  
T.P. Sastry ◽  
K.S. Subramanian ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Regeneration In Vitro

In vitro drug release study from hydroxyapatite-alumina composites

2018 ◽  
Vol 89 (2) ◽  
pp. 521-530 ◽  
Author(s):  
J. M. C. Teixeira ◽  
J. S. V. Alburquerque ◽  
E. B. Duarte ◽  
S. A. Silva ◽  
R. E. F. Q. Nogueira
Keyword(s):  
Drug Release ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Alumina Composites ◽  
Release Study
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