Effect of expanded bone marrow-derived osteoprogenitor cells seeded into polycaprolactone/tricalcium phosphate scaffolds in new bone regeneration of rabbit mandibular defects

2018 ◽  
Vol 29 (3) ◽  
Author(s):  
Thongchai Nuntanaranont ◽  
Tapanee Promboot ◽  
Srisurang Sutapreyasri
Keyword(s):  
Bone Marrow ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Osteoprogenitor Cells

Bone Regeneration with Autologous Plasma, Bone Marrow Stromal Cells, and Porous β-Tricalcium Phosphate in Nonhuman Primates

2009 ◽  
Vol 15 (7) ◽  
pp. 1489-1499 ◽  
Author(s):  
Ichiro Torigoe ◽  
Shinichi Sotome ◽  
Akio Tsuchiya ◽  
Toshitaka Yoshii ◽  
Hidetsugu Maehara ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Regeneration ◽  
Stromal Cells ◽  
Tricalcium Phosphate ◽  
Bone Marrow Stromal Cells ◽  
Nonhuman Primates ◽  
Marrow Stromal Cells ◽  
Autologous Plasma

Bone Regeneration of Canine Skull Using Bone Marrow-Derived Stromal Cells and β-Tricalcium Phosphate

2007 ◽  
Vol 117 (6) ◽  
pp. 997-1003 ◽  
Author(s):  
Hiroo Umeda ◽  
Shin-ichi Kanemaru ◽  
Masaru Yamashita ◽  
Masanao Kishimoto ◽  
Yoshihiro Tamura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Regeneration ◽  
Stromal Cells ◽  
Tricalcium Phosphate

Tissue-Engineered Hydroxyapatite Bone Scaffold Impregnated with Osteoprogenitor Cells Promotes Bone Regeneration in Sheep Model

2021 ◽  
Author(s):  
Mohd Yazid Bajuri ◽  
Nanchappan Selvanathan ◽  
Fatin Nadira Dzeidee Schaff ◽  
Muhammad Haziq Abdul Suki ◽  
Angela Min Hwei Ng
Keyword(s):  
Bone Regeneration ◽  
Bone Scaffold ◽  
Sheep Model ◽  
Osteoprogenitor Cells

scholarly journals Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
S. Lee ◽  
L. H. Remark ◽  
A. M. Josephson ◽  
K. Leclerc ◽  
E. Muiños Lopez ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Notch Signaling ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Canonical Wnt Signaling ◽  
Osteoprogenitor Cells ◽  
Intramembranous Bone ◽  
Proliferation And Differentiation ◽  
Canonical Wnt ◽  
Wnt Signal

AbstractAdult bone regeneration is orchestrated by the precise actions of osteoprogenitor cells (OPCs). However, the mechanisms by which OPC proliferation and differentiation are linked and thereby regulated are yet to be defined. Here, we present evidence that during intramembranous bone formation OPC proliferation is controlled by Notch signaling, while differentiation is initiated by activation of canonical Wnt signaling. The temporospatial separation of Notch and Wnt signal activation during the early stages of bone regeneration suggests crosstalk between the two pathways. In vitro and in vivo manipulation of the two essential pathways demonstrate that Wnt activation leads to initiation of osteogenic differentiation and at the same time inhibits Notch signaling, which results in termination of the proliferative phase. Here, we establish canonical Wnt signaling as a key regulator that facilitates the crosstalk between OPC proliferation and differentiation during intramembranous, primary bone healing.

Sign in / Sign up

Export Citation Format

Share Document