A bioactive nano-calcium phosphate paste for in-situ transfection of BMP-7 and VEGF-A in a rabbit critical-size bone defect: results of an in vivo study

2019 ◽  
Vol 30 (2) ◽  
Author(s):  
Carsten Schlickewei ◽  
Till O. Klatte ◽  
Yasmin Wildermuth ◽  
Georg Laaff ◽  
Johannes M. Rueger ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Defect ◽  
Critical Size ◽  
In Vivo Study

In Vivo Study of Two Carbamide Peroxide Gels with Different Desensitizing Agents

10.2341/07-10 ◽  
2007 ◽  
Vol 32 (6) ◽  
pp. 549-555 ◽  
Author(s):  
B. A. Matis ◽  
M. A. Cochran ◽  
G. J. Eckert ◽  
J. I. Matis
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Clinical Relevance ◽  
Potassium Nitrate ◽  
In Vivo Study ◽  
Carbamide Peroxide ◽  
Desensitizing Agents

Clinical Relevance Under the conditions of this study, 15% carbamide peroxide with potassium nitrate and fluoride exhibited greater bleaching potential but exhibited no difference in sensitivity compared to 16% carbamide peroxide with amorphous calcium phosphate.

scholarly journals Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Che Nor Zarida Che Seman ◽  
Zamzuri Zakaria ◽  
Zunariah Buyong ◽  
Mohd Shukrimi Awang ◽  
Ahmad Razali Md Ralib @ Md Raghib
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Tissue ◽  
Bone Repair ◽  
Critical Size ◽  
Healing Process ◽  
Bone Defects ◽  
Calcium Phosphate Bone Cement ◽  
Rabbit Tibia

Introduction: A novel injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tricalcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could be a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

scholarly journals Augmentation of bone defect healing using a new biocomposite scaffold: An in vivo study in sheep

2010 ◽  
Vol 6 (9) ◽  
pp. 3755-3762 ◽  
Author(s):  
U. van der Pol ◽  
L. Mathieu ◽  
S. Zeiter ◽  
P.-E. Bourban ◽  
P.-Y. Zambelli ◽  
...  
Keyword(s):  
Bone Defect ◽  
In Vivo Study ◽  
Defect Healing ◽  
Bone Defect Healing

In vivo evaluation of interactions between biphasic calcium phosphate (BCP)-niobium pentoxide (Nb2O5) nanocomposite and tissues using a rat critical-size calvarial defect model

2020 ◽  
Vol 31 (8) ◽  
Author(s):  
Helio de Jesus Kiyochi Junior ◽  
Aline Gabriela Candido ◽  
Taiana Gabriela Moretti Bonadio ◽  
José Adauto da Cruz ◽  
Mauro Luciano Baesso ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Critical Size ◽  
Niobium Pentoxide ◽  
Calvarial Defect ◽  
Defect Model ◽  
In Vivo Evaluation

scholarly journals The Importance of Understanding Differences in a Critical Size Model: a Preliminary In Vivo Study Using Tibia and Parietal Bone to Evaluate the Reaction with Different Biomaterials

2019 ◽  
Vol 22 (1) ◽  
Author(s):  
Guinea Brasil Camargo Cardoso ◽  
Erivelto Luis Chacon ◽  
Luis Ricardo Barbosa Maia ◽  
Cecília Amélia de Carvalho Zavaglia ◽  
Marcelo Rodrigues da Cunha
Keyword(s):  
Critical Size ◽  
Parietal Bone ◽  
In Vivo Study ◽  
Size Model

scholarly journals The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds

RSC Advances ◽  
2020 ◽  
Vol 10 (13) ◽  
pp. 7708-7717 ◽  
Author(s):  
Rong Zhou ◽  
Hai-Jian Ni ◽  
Jin-Hui Peng ◽  
Ning Liu ◽  
Shu Chen ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Bone Defect ◽  
High Performance ◽  
Calcium Phosphates ◽  
Sustained Drug Release ◽  
Bone Defect Repair ◽  
Defect Repair

Calcium phosphate modified tantalum scaffolds displayed high performance on mineralization, sustained drug release and in vivo bone defect repair.

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