Efficiency of a Single well IgG, IgM and IgA Anti T. gondii Fluorimetric Assay for Pre-natal Screening for Congenital Toxoplasmosis

2022 ◽  
Author(s):  
Jaqueline Polizeli Rodrigues ◽  
Heitor Franco de Andrade Junior
Keyword(s):  
Congenital Toxoplasmosis ◽  
Fluorimetric Assay ◽  
Single Well

An Effective Approach for Automatic Rock-Typing and Calibration Using Single-Well Models

2011 ◽  
Author(s):  
Sachin Kumar Sharma ◽  
Alexis Vincent Carrillat ◽  
Torsten Friedel
Keyword(s):  
Rock Typing ◽  
Single Well ◽  
Well Models

Single-Well Chemical Tracer Test Experience in the Gulf of Guinea to Determine Remaining Oil Saturation

2011 ◽  
Author(s):  
Carolina Romero ◽  
Nicolas Agenet ◽  
Alexandre Lesage ◽  
Gilles Cassou
Keyword(s):  
Tracer Test ◽  
Gulf Of Guinea ◽  
Oil Saturation ◽  
Chemical Tracer ◽  
Remaining Oil ◽  
Single Well

No Wait-On-Cement (NO WOC) Successfully Applied in Pertamina Hulu Mahakam (PHM) and Creating Significant Well Rig Time Saving

2020 ◽  
Author(s):  
H., A. Sinaga
Keyword(s):  
Hard Work ◽  
Time Saving ◽  
Drilling Technique ◽  
Single Well ◽  
No Wait

As the new operator of the Mahakam Block started in 2017, Pertamina Hulu Mahakam (PHM) were challenged to ramp up operations in order to combat massive production decline. At the same time, reducing well cost was also a paramount importance to ensure that the economic targets of the wells were achieved following the reduction of well stakes. One of the remaining unsolved enigmas is how to achieve No Wait-on-Cement (NO WOC) on surface diverter section as this will create a lot of rig time saving both on single well and batch operations. The project begins with several different kinds of proposal until the best solutions were identified fulfilling safety, simplicity of operations and acceptable cost and finally were put in place with very satisfying results. The main key principle is conversion wellhead stages following well architecture while there were several modifications of casing hanger, adapter, additional materials & modified procedure. Rig time saving, additional operational gain and a promising new “breakthrough” of drilling technique become a significant impact of the successful effort. Now the method has become a standard in PHM operations and has already been integrated to SDI (Standard Drilling Instruction). The merit of this endless hard work could possibly be gained by other operators as it will create more added values both tangible and intangible.

Gas-Water Flow Behaviour During Mutual Displacement in Porous Media

2017 ◽  
Vol 10 (1) ◽  
pp. 13-22
Author(s):  
Renyi Cao ◽  
Junjie Xu ◽  
Xiaoping Yang ◽  
Renkai Jiang ◽  
Changchao Chen
Keyword(s):  
Porous Media ◽  
Relative Permeability ◽  
Gas Storage ◽  
Fluid Distribution ◽  
Water Displacement ◽  
Phase Zone ◽  
Two Phase ◽  
Flow Process ◽  
Single Well ◽  
Mutual Displacement

During oilfield development, there exist multi-cycle gas–water mutual displacement processes. This means that a cycling process such as water driving gas–gas driving water–water driving gas is used for the operation of injection and production in a single well (such as foam huff and puff in single well or water-bearing gas storage). In this paper, by using core- and micro-pore scales model, we study the distribution of gas and water and the flow process of gas-water mutual displacement. We find that gas and water are easier to disperse in the porous media and do not flow in continuous gas and water phases. The Jamin effect of the gas or bubble becomes more severe and makes the flow mechanism of multi-cycle gas–water displacement different from the conventional water driving gas or gas driving water processes. Based on experiments of gas–water mutual displacement, the changing mechanism of gas–water displacement is determined. The results indicate that (1) after gas–water mutual displacement, the residual gas saturation of a gas–water coexistence zone becomes larger and the two-phase zone becomes narrower, (2) increasing the number of injection and production cycles causes the relative permeability of gas to increase and relative permeability for water to decrease, (3) it becomes easier for gas to intrude and the invaded water becomes more difficult to drive out and (4) the microcosmic fluid distribution of each stage have a great difference, which caused the two-phase region becomes narrower and effective volume of gas storage becomes narrower.

Timing and type of prenatal treatment for congenital toxoplasmosis

2003 ◽  
Author(s):  
R Thiébaut ◽  
RE Gilbert ◽  
L Gras ◽  
G Chêne
Keyword(s):  
Congenital Toxoplasmosis ◽  
Prenatal Treatment

A new fluorimetric assay for streptothricins

1984 ◽  
Vol 24 (10) ◽  
pp. 709-711 ◽  
Author(s):  
G. Hesse ◽  
W. Römer ◽  
N. Miosga
Keyword(s):  
Fluorimetric Assay

scholarly journals A Novel Calcium-Dependent Protein Kinase 1 Inhibitor Potently Prevents Toxoplasma gondii Transmission to Foetuses in Mouse

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4203
Author(s):  
Héloïse Débare ◽  
Nathalie Moiré ◽  
Firmin Baron ◽  
Louis Lantier ◽  
Bruno Héraut ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Toxoplasma Gondii ◽  
Intraperitoneal Administration ◽  
Congenital Toxoplasmosis ◽  
Parasite Burden ◽  
Oral Route ◽  
Dependent Protein Kinase ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Calcium Dependent Protein Kinase

Treatments currently used to prevent congenital toxoplasmosis are non-specific of Toxoplasma gondii and have grievous side effects. To develop a more specific and less toxic drug, we have designed SP230, an imidazo[1,2-b]pyridazine salt targeting the Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) and active against acute toxoplasmosis in mice. Efficiency of SP230 to inhibit foetal transmission of the parasite was evaluated in a mouse model of congenital toxoplasmosis. Swiss mice were infected at mid-pregnancy with tachyzoites or cysts of the ME49 strain of T. gondii by intraperitoneal and oral route, respectively, and treated with SP230 at 50 mg/kg for 5 days by the same routes. Parasite burden in organs of dams and in foetuses was measured by quantitative PCR. Intraperitoneal administration of SP230 drastically reduced the number of parasites (more than 97% of reduction) in the brain and lungs of dams, and led to a reduction of 66% of parasite burden in foetuses. Oral administration of SP230 was particularly efficient with 97% of reduction of parasite burdens in foetuses. SP230 did not impact number and weight of offspring in our conditions. This inhibitor of TgCDPK1 is a promising candidate for the development of alternative therapeutics to treat infected pregnant women.

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