Calcium sulfate bone scaffolds with controllable porous structure by selective laser sintering

2015 ◽  
Vol 22 (5) ◽  
pp. 1171-1178 ◽  
Author(s):  
Jianhua Zhou ◽  
Chengde Gao ◽  
Pei Feng ◽  
Tao Xiao ◽  
Cijun Shuai ◽  
...  
Keyword(s):  
Porous Structure ◽  
Calcium Sulfate ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Bone Scaffolds

Artificial bone scaffolds of coral imitation prepared by selective laser sintering

2020 ◽  
Vol 104 ◽  
pp. 103664 ◽  
Author(s):  
Yunsong Shi ◽  
Teng Pan ◽  
Wei Zhu ◽  
Chunze Yan ◽  
Zhidao Xia
Keyword(s):  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Artificial Bone ◽  
Bone Scaffolds

Microsphere-based selective laser sintering for building macroporous bone scaffolds with controlled microstructure and excellent biocompatibility

2015 ◽  
Vol 135 ◽  
pp. 81-89 ◽  
Author(s):  
Yingying Du ◽  
Haoming Liu ◽  
Jiaqi Shuang ◽  
Jianglin Wang ◽  
Jun Ma ◽  
...  
Keyword(s):  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Bone Scaffolds

Fabrication of three dimensional open porous regular structure of PA-2200 for enhanced strength of scaffold using selective laser sintering

2016 ◽  
Vol 22 (4) ◽  
pp. 752-765 ◽  
Author(s):  
Jatender Pal Singh ◽  
Pulak M. Pandey ◽  
Anita Kamra Verma
Keyword(s):  
Porous Structure ◽  
Pore Size ◽  
Process Parameters ◽  
Cell Structure ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Laser Sintering ◽  
Open Cell ◽  
Content Type ◽  
Open Porous Structure

Purpose Scaffolds are essentially required to have open porous structure for facilitating bone to grow. They are generally placed on those bone defective/fractured sites which are more prone to compressive loading. Open porous structure lacks in strength in comparison to solid. Selective laser sintering (SLS) process is prominently used for fabrication of polymer/composite scaffolds. So, this paper aims to study for fabrication of three-dimensional open porous scaffolds with enhanced strength, process parameters of SLS of a biocompatible material are required to be optimized. Design/methodology/approach Regular open porous structures with suitable pore size as per computer-aided design models were fabricated using SLS. Polyamide (PA-2200) was used to fabricate the specimen/scaffold. To optimize the strength of the designed structure, response surface methodology was used to design the experiments. Specimens as per ASTM D695 were fabricated using SLS and compressive testing was carried out. Analysis of variance was done for estimating contribution of individual process parameters. Optimized process parameters were obtained using a trust region algorithm and correlated with experimental results. Accuracy of the fabricated specimen/scaffold was also assessed in terms of IT grades. In vitro cell culture on the fabricated structures confirmed the biocompatibility of polyamide (PA-2200). Findings Optimized process parameters for open cell process structures were obtained and confirmed experimentally. Laser power, hatch spacing and layer thickness have contributed more in the porous part’s strength than scan speed. The accuracy of the order of IT16 has been found for all functional dimensions. Cell growth and proliferation confirmed biocompatibility of polyamide (PA-2200) for scaffold applications. Originality/value This paper demonstrates the biocompatibility of PA-2200 for scaffold applications. The optimized process parameters of SLS process for open cell structure having pore size 1.2 × 1.2 mm2 with strut diameter of 1 mm have been obtained. The accuracy of the order of IT16 was obtained at the optimized process factors.

Revealing the compressive and flow properties of novel bone scaffold structure manufactured by selective laser sintering technique

2022 ◽  
pp. 095441192110704
Author(s):  
S Rashia Begum ◽  
M Saravana Kumar ◽  
M Vasumathi ◽  
Muhammad Umar Farooq ◽  
Catalin I Pruncu
Keyword(s):  
Selective Laser Sintering ◽  
Testing Machine ◽  
Laser Sintering ◽  
Maximum Pressure ◽  
Cfd Analysis ◽  
Bone Scaffold ◽  
Ansys Fluent ◽  
Bone Scaffolds ◽  
Novel Structure ◽  
Input Parameters

Additive manufacturing is revolutionizing the field of medical sciences through its key application in the development of bone scaffolds. During scaffold fabrication, achieving a good level of porosity for enhanced mechanical strength is very challenging. The bone scaffolds should hold both the porosity and load withstanding capacity. In this research, a novel structure was designed with the aim of the evaluation of flexible porosity. A CAD model was generated for the novel structure using specific input parameters, whereas the porosity was controlled by varying the input parameters. Poly Amide (PA 2200) material was used for the fabrication of bone scaffolds, which is a biocompatible material. To fabricate a novel structure for bone scaffolds, a Selective Laser Sintering machine (SLS) was used. The displacement under compression loads was observed using a Universal Testing Machine (UTM). In addition to this, numerical analysis of the components was also carried out. The compressive stiffness found through the analysis enables the verification of the load withstanding capacity of the specific bone scaffold model. The experimental porosity was compared with the theoretical porosity and showed almost 29% to 30% reductions when compared to the theoretical porosity. Structural analysis was carried out using ANSYS by changing the geometry. Computational Fluid Dynamics (CFD) analysis was carried out using ANSYS FLUENT to estimate the blood pressure and Wall Shear Stress (WSS). From the CFD analysis, maximum pressure of 1.799 Pa was observed. Though the porosity was less than 50%, there was not much variation of WSS. The achievement from this study endorses the great potential of the proposed models which can successfully be adapted for the required bone implant applications.

Fabrication of Bone Scaffolds Using Selective Laser Sintering

2013 ◽  
Vol 19 (5) ◽  
pp. 1345-1348
Author(s):  
Fwu-Hsing Liu ◽  
Sheng-Lih Yeh ◽  
Chil-Chyuan Kuo
Keyword(s):  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Bone Scaffolds

Selective Laser Sintering of Biomaterials and Composites State of the Art and Perspectives

2020 ◽  
Vol 1012 ◽  
pp. 278-283
Author(s):  
Henrique Schappo ◽  
Lya Piaia ◽  
Dachamir Hotza ◽  
Gean Vitor Salmoria
Keyword(s):  
Review Paper ◽  
Complex Geometry ◽  
State Of The Art ◽  
Complex Structure ◽  
Selective Laser Sintering ◽  
Processing Parameters ◽  
Laser Sintering ◽  
Manufacturing Processes ◽  
Bone Scaffolds ◽  
Wide Range

Human bone has a complex geometry, varying its structure and composition. Additive manufacturing processes, such as selective laser sintering (SLS), can produce bone scaffolds with a wide range of biomaterials. Through SLS a complex structure with highly interconnected porous can be fabricated from a combination of materials. Composites made from biopolymers and bioceramics have shown promising results for bone regeneration, although some properties still must be enhanced. Finding suitable processing parameters is mandatory to achieve required final properties. This review paper is focused on polymer/ceramics using SLS machines in the last 10 years.

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