Let G be a connected graph. The Hyper-Zagreb index of a connected graph G is defined as HM(G) = Σuv∈EG [dG(u)+dG(v)]2, where dG(v)
is the degree of the vertex v in G. In this paper, the Hyper-Zagreb Gindex of the generalized hierarchical, Cartesian, cluster, corona products and four new sums of graphs according to some invariants of the factors are computed, respectively. As applications, we present explicit
formulas for the HM index of the linear phenylene Fn, the C4 nanotorus Cm□Cn, the C4 nanotubes Pm□Cn,
the l-dimensional hypercubes Ql , the zig-zag polyhex nanotube TUHC6[2n, 2], the hexagonal chain ln, the regular dicentric dendrimer DDp,r and so forth.