The Effect of Leptin on Sex Hormones and Antioxidant Enzyme Levels in Obese and Normal Male Rats

2018 ◽  
Vol 25 (3) ◽  
pp. 1105-1111 ◽  
Author(s):  
Hossein Cheraghi ◽  
Morteza Zendehdel ◽  
Jamshid GhiasiGhalehkandi ◽  
Parviz Tajik ◽  
Negar Panahi
Keyword(s):  
Antioxidant Enzyme ◽  
Sex Hormones ◽  
Male Rats ◽  
Normal Male

The effect of sex and sex hormones on the infection of rats by Trichinella spiralis

1972 ◽  
Vol 50 (5) ◽  
pp. 597-602 ◽  
Author(s):  
Sarojam K. Mankau ◽  
Raymond Hamilton
Keyword(s):  
Sex Hormones ◽  
Worm Burden ◽  
Testosterone Propionate ◽  
Marked Decrease ◽  
Trichinella Spiralis ◽  
Male Rats ◽  
Normal Male ◽  
Normal Males

Male hooded rats infected with Trichinella spiralis larvae had three times more larvae in the muscles than females. Gonadectomized males injected with stilbestrol had a lower worm burden than normal males. Gonadectomized females injected with testosterone propionate harbored far more worms than normal females. Stilbestrol administered to normal male rats caused a marked decrease in T. spiralis, while testosterone administered to normal females resulted in a significant increase in the number of parasites.

Sex Hormones and Phytomenadione Evidence for their Relationship in an Induced Coagulation Defect

1975 ◽  
Author(s):  
J. H. Sanderson ◽  
I. S. Chart ◽  
C. Shingles
Keyword(s):  
Sex Hormones ◽  
Sex Differentiation ◽  
Male Rats ◽  
Normal Male ◽  
Coagulation Defect ◽  
Dose Levels

Rats dosed with benzyl 3,5-dichloro-2,6-difluoro-2-pyridyl ether show a coagulation defect which is much more severe in males than females, and dose levels can be chosen at which males only are affected. The defect is produced by a lowering of Factors VII X and II.This sex differentiation can be abolished if male rats are castrated or if they are treated with oestrogens, and normal male rats can be protected by treatment with Phytomenadione.It is suggested that the use of this compound may provide a tool for understanding mechanisms of anti-coagulation.

DER EINFLUSS VON RESERPIN AUF DIE ANTITHYREOIDALE WIRKUNG VON KALIUMPERCHLORAT

1962 ◽  
Vol 39 (3) ◽  
pp. 423-430
Author(s):  
H. L. Krüskemper ◽  
F. J. Kessler ◽  
E. Steinkrüger
Keyword(s):  
Thyroid Gland ◽  
Male Rats ◽  
Normal Male ◽  
Tissue Respiration ◽  
List Type ◽  
Morphological Alterations ◽  
Hormone Synthesis ◽  
Stimulation Of

ABSTRACT 1. Reserpine does not inhibit the tissue respiration of liver in normal male rats (in vitro). 2. The decrease of tissue respiration of the liver with simultaneous morphological stimulation of the thyroid gland after long administration of reserpine is due to a minute inhibition of the hormone synthesis in the thyroid gland. 3. The morphological alterations of the thyroid in experimental hypothyroidism due to perchlorate can not be prevented with reserpine.

Differential regulation of insulin resistance and hypertension by sex hormones in fructose-fed male rats

2005 ◽  
Vol 289 (4) ◽  
pp. H1335-H1342 ◽  
Author(s):  
Harish Vasudevan ◽  
Hong Xiang ◽  
John H. McNeill
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Sex Hormones ◽  
Threshold Value ◽  
Relative Increase ◽  
Estrogen Treatment ◽  
Male Rats ◽  
Normal Chow

Differences in gender are in part responsible for the development of insulin resistance (IR) and associated hypertension. Currently, it is unclear whether these differences are dictated by gender itself or by the relative changes in plasma estrogen and/or testosterone. We investigated the interrelationships between testosterone and estrogen in the progression of IR and hypertension in vivo in intact and gonadectomized fructose-fed male rats. Treatment with estrogen significantly reduced the testosterone levels in both normal chow-fed and fructose-fed rats. Interestingly, fructose feeding induced a relative increase in estradiol levels, which did not affect IR in both intact and gonadectomized fructose-fed rats. However, increasing the estrogen levels improved insulin sensitivity in both intact and gonadectomized fructose-fed rats. In intact males, fructose feeding increased the blood pressure (140 ± 2 mmHg), which was prevented by estrogen treatment. However, the blood pressure in the fructose-fed estrogen rats (125 ± 1 mmHg) was significantly higher than that of normal chow-fed (113 ± 1 mmHg) and fructose-fed gonadectomized rats. Estrogen treatment did not affect the blood pressure in gonadectomized fructose-fed rats (105 ± 2 mmHg). These data suggest the existence of a threshold value for estrogen below which insulin sensitivity is unaffected. The development of hypertension in this model is dictated solely by the presence or absence of testosterone. In summary, the development of IR and hypertension is governed not by gender per se but by the interactions of specific sex hormones such as estrogen and testosterone.

Certain aspects of the host-parasite relationship ofNematospiroides dubius(Baylis). II. The effect of sex on experimental infections in the rat (an abnormal host)

Parasitology ◽  
1961 ◽  
Vol 51 (3-4) ◽  
pp. 499-510 ◽  
Author(s):  
Colin Dobson
Keyword(s):  
Male Rats ◽  
Male Rat ◽  
Normal Male ◽  
Female Rat ◽  
Castrate Male ◽  
Parasite Relationship ◽  
Nematospiroides Dubius ◽  
Resistance To Infection ◽  
Host Parasite ◽  
The Relationship

1. The male rat is more susceptible to infections ofNematospiroides dubiusthan the female. As the rat grows older the resistance of the female rat to infection increases at a greater rate than that of the male.2. The course of the infection is modified by the sex of the host.3. More larvae penetrated the intestinal mucosa to encyst in the male than in the female. More larvae, however, formed cysts in the female than in the male rat by the fifth day.4. The male harboured more adult worms than the female rat, although this difference was not significant in the immature animals.5. The sex resistance of the rat toN. dubiusinfections was removed by bilateral gonadectomy. Castration decreased the susceptibility of the male rat, while spaying increased it in the female compared with the susceptibility in the respective normal hosts.6. Subsequent replacement of the homologous sex hormone in the gonadectomized rat restores the sex resistance, and may even increase it (particularly in the immature animals). Oestradiol increased the resistance of the spayed female rat, while testosterone increased the susceptibility of the castrate male rat to infection.7. Oestradiol implanted in castrate male rats increased the resistance of these hosts to a greater level than was shown in the normal male rat.8. The rat shows a marked age resistance over which the sex resistance is superimposed.9. The relationship between the sex of the host and its resistance to infection is discussed.This work was done during the tenure of a Department of Scientific and Industrial Research Studentship. My thanks are due to Dr E. T. B. Francis for his helpful and critical supervision and to Professor I. Chester Jones, in whose department the work was done, for the facilities he provided.

scholarly journals Galactose ingestion increases vascular permeability and collagen solubility in normal male rats.

1987 ◽  
Vol 79 (2) ◽  
pp. 367-373 ◽  
Author(s):  
K Chang ◽  
M Tomlinson ◽  
J R Jeffrey ◽  
R G Tilton ◽  
W R Sherman ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Male Rats ◽  
Normal Male

Comparative Effects of Aqueous and Ethanolic Leaf Extracts of Gongronema latifolium on Serum Kidney and Liver Biomarkers of Normal Male Rats

2011 ◽  
Vol 4 (7) ◽  
pp. 540-547 ◽  
Author(s):  
C.O. Nwangwu Spencer ◽  
J. Josiah Sunday . ◽  
E. Abubakar Teslimat ◽  
O. Ajeigbe Kazeem ◽  
O. Osakwe Eguagie ◽  
...  
Keyword(s):  
Male Rats ◽  
Normal Male ◽  
Leaf Extracts ◽  
Gongronema Latifolium

RAT INTESTINAL SUCRASE: II. THE EFFECTS OF RAT AGE AND SEX AND OF DIET ON SUCRASE ACTIVITY

1963 ◽  
Vol 41 (1) ◽  
pp. 917-929 ◽  
Author(s):  
D. G. R. Blair ◽  
W. Yakimets ◽  
J. Tuba
Keyword(s):  
Control Diet ◽  
Male Rats ◽  
Normal Male ◽  
Casein Diet ◽  
Sucrase Activity ◽  
Adult Rats ◽  
Sucrose Diet ◽  
Enzyme Adaptation ◽  
Intestinal Sucrase ◽  
Intestinal Sucrase Activity

Intestinal sucrase activity of the rat varies with the age, but not the sex, of the animal. Sucrase activity of rats 23 days of age was approximately two-thirds that of adults.Sucrase activity of adult rats was significantly decreased by several days of fasting. The decrease was rapid during the first 2 to 4 days of the fast, but became negligible thereafter.Diets containing large (70%) amounts of sucrose, galactose, melizitose, or α-methyl-D-glucoside produced highly significant increases in intestinal sucrase levels (compared with a carbohydrate-free, high-casein control diet) when fed ad libitum for 24 hours to adult male rats previously fasted for 3 days. Similar diets containing fructose, fructose plus glucose in equimolar amounts, or maltose significantly increased sucrase activity, but diets containing glucose, mannose, xylose, or lactose were not stimulatory. A 70% raffinose diet significantly decreased sucrase activity. Normal male rats which were fed the 70% sucrose diet for 4 weeks had sucrase activities similar to those of controls fed Purina fox checkers, but animals fed the carbohydrate-free, high-casein diet for 1 day or longer had sucrase activities significantly lower than those of controls. The significance of these observations in regard to enzyme "adaptation" is discussed.

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