Effects of pharmacological preconditioning by emodin/oleanolic acid treatment and/or ischemic preconditioning on mitochondrial antioxidant components as well as the susceptibility to ischemia-reperfusion injury in rat hearts

2006 ◽  
Vol 288 (1-2) ◽  
pp. 135-142 ◽  
Author(s):  
Ying Du ◽  
Kam Ming Ko
Keyword(s):  
Reperfusion Injury ◽  
Oleanolic Acid ◽  
Ischemic Preconditioning ◽  
Acid Treatment ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Hearts ◽  
Pharmacological Preconditioning

scholarly journals Impact of Three Methods of Ischemic Preconditioning on Ischemia-Reperfusion Injury in a Pig Model of Liver Transplantation

2021 ◽  
pp. 1-10
Author(s):  
Alessandro Rodrigo Belon ◽  
Ana Cristina Aoun Tannuri ◽  
Daniel de Albuquerque Rangel Moreira ◽  
Jose Luiz Figueiredo ◽  
Alessandra Matheus da Silva ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Pig Model

scholarly journals The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats

2017 ◽  
Vol 32 (7) ◽  
pp. 559-567 ◽  
Author(s):  
Teresinha Regina Ribeiro de Oliveira ◽  
Geraldo Ferreira de Oliveira ◽  
Ricardo Santos Simões ◽  
Eduardo Hiroshi Tikazawa ◽  
Hugo Pequeno Monteiro ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

Oleanolic Acid Improves the Symptom of Renal Ischemia Reperfusion Injury via the PI3K/AKT Pathway

2020 ◽  
pp. 1-6
Author(s):  
JinRan Yang ◽  
Xinchang Li ◽  
Hua Yang ◽  
Chenmei Long
Keyword(s):  
Reperfusion Injury ◽  
Oleanolic Acid ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Expression Level ◽  
Tissue Homogenate ◽  
Model Group ◽  
Therapeutic Groups ◽  
Renal Ischemia Reperfusion Injury

<b><i>Purpose:</i></b> The aim of this study was to investigate the therapeutic effect of oleanolic acid (OA) on the renal ischemia reperfusion injury (RIRI) and the possible mechanism. <b><i>Methods:</i></b> The RIRI model was successfully established in rats. OA, LY294002 (a PI3K inhibitor), and OA combined with LY294002 were dosed to rats in 3 therapeutic groups, respectively. The blood was collected to detect the concentration of Cr and BUN by ELISA. The kidney of each rat was collected to detect the concentration of renal injury factor (Kim-1) and the HE staining was performed. Western blot was used to detect the expression level of PI3K, p-AKT, AKT, PDK1, Skp2, and p27 in the renal tissue homogenate. <b><i>Results:</i></b> The symptom of vacuolar degeneration and interstitial edema was greatly improved in the rat kidney from the 3 therapeutic groups, compared with that from the RIRI model group. No significant difference was observed among the 3 therapeutic groups. The concentration of Cr in the 3 therapeutic groups was greatly lower than that in the RIRI model group. The expression level of p-AKT/AKT, PI3K, PDK1, Skp2, and p27 in OA group, LY294002 group, and OA combined with LY294002 group was significantly lower than that in the RIRI model group, respectively. <b><i>Conclusion:</i></b> OA could improve the symptom of RIRI, possibly by inhibiting PI3K/AKT signal pathway.

scholarly journals Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats

2016 ◽  
Vol 13 (3) ◽  
pp. 2511-2517 ◽  
Author(s):  
TONG-MIN XUE ◽  
LI-DE TAO ◽  
JIE ZHANG ◽  
PEI-JIAN ZHANG ◽  
XIA LIU ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia

scholarly journals Ischemic preconditioning increases GSK-3β/β-catenin levels and ameliorates liver ischemia/reperfusion injury in rats

2015 ◽  
Vol 35 (6) ◽  
pp. 1625-1632 ◽  
Author(s):  
YICHAO YAN ◽  
GUANGYING LI ◽  
XIAOFENG TIAN ◽  
YINGJIANG YE ◽  
ZHIDONG GAO ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia ◽  
Gsk 3Β
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