Cannabinoids pharmacological effects are beyond the palliative effects: CB2 cannabinoid receptor agonist induced cytotoxicity and apoptosis in human colorectal cancer cells (HT-29)

2021 ◽  
Author(s):  
Aylar Alenabi ◽  
Hassan Malekinejad
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Receptor Agonist ◽  
Cannabinoid Receptor ◽  
Pharmacological Effects ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Ht 29 ◽  
Human Colorectal Cancer Cells

scholarly journals miR-214 sensitizes human colorectal cancer cells to doxorubicin by p53 targeting

2020 ◽  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
P53 Expression ◽  
Colorectal Cancer Cells ◽  
Scratch Wound ◽  
And Migration ◽  
Induced Apoptosis ◽  
Ht 29 ◽  
Human Colorectal Cancer Cells

Objectives: This study aimed to investigate the potential function of miR-214 in the apoptosis induction by targeting p53 in human colorectal cancer cells (CRC) in combination with doxorubicin (DOX). Methods: miR-214 mimics were transfected to HT-29 CRC cells. Following that, the transfected cells were treated with DOX. Cell viability, apoptosis, and migration were evaluated by MTT, flow cytometry, and scratch-wound motility assays, respectively. Furthermore, the expression level of miR-214 and p53 was evaluated by qRT-PCR. Results: miR-214 transfection significantly inhibited the cell proliferation rate (P<0.05), induced apoptosis (P<0.05), and harnessed migration (P<0.05) in the HT-29 cells after 48 h. Furthermore, more effectiveness was observed in combination with DOX. Additionally, miR-214 transfection led to a reduction in p53 expression offering that it might be a potential target for miR-214. Conclusion: In conclusion, miR-214 sensitizes HT-29 cells to doxorubicin by targeting p53 indicating the significant role of this miRNA in colorectal cancer chemotherapy.

scholarly journals Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action

2008 ◽  
Vol 122 (10) ◽  
pp. 2223-2232 ◽  
Author(s):  
Isabel Winkelmann ◽  
Anna-Maria Näßl ◽  
Hannelore Daniel ◽  
Uwe Wenzel
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Mode Of Action ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Ht 29 ◽  
Human Colorectal Cancer Cells

scholarly journals Metallothionein 1G promotes the differentiation of HT-29 human colorectal cancer cells

2017 ◽  
Vol 37 (5) ◽  
pp. 2633-2651 ◽  
Author(s):  
Juan Martín Arriaga ◽  
Alicia Inés Bravo ◽  
José Mordoh ◽  
Michele Bianchini
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Ht 29 ◽  
Human Colorectal Cancer Cells

Rosiglitazone enhances the radiosensitivity of p53-mutant HT-29 human colorectal cancer cells

2010 ◽  
Vol 394 (3) ◽  
pp. 774-779 ◽  
Author(s):  
Shu-Jun Chiu ◽  
Ching-Hui Hsaio ◽  
Ho-Hsing Tseng ◽  
Yu-Han Su ◽  
Wen-Ling Shih ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Ht 29 ◽  
Human Colorectal Cancer Cells
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