Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis

2019 ◽  
Vol 35 (1) ◽  
pp. 149-157
Author(s):  
Binggang Guan ◽  
Rongchun Chen ◽  
Mingliang Zhong ◽  
Ning Liu ◽  
Qin Chen
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protective Effect ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

Protective Effect of Ginkgolide B Against Acute Spinal Cord Injury in Rats and Its Correlation with the JAK/STAT Signaling Pathway

2012 ◽  
Vol 38 (3) ◽  
pp. 610-619 ◽  
Author(s):  
Yongxing Song ◽  
Zhongyou Zeng ◽  
Caiyi Jin ◽  
Jianqiao Zhang ◽  
Baoyue Ding ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protective Effect ◽  
Signaling Pathway ◽  
Acute Spinal Cord Injury ◽  
Ginkgolide B ◽  
Cord Injury ◽  
Stat Signaling

Protective effect of Boldine against neuroinflammation in spinal cord injury in rats

2021 ◽  
pp. 1-7
Author(s):  
Jigao Feng ◽  
Junchi Liu ◽  
Xu Liu ◽  
Zhaoyou Qiu ◽  
Caicai Zhang
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protective Effect ◽  
Locomotor Function ◽  
Medical Need ◽  
Tnf Α ◽  
Flow Cytometry Experiment ◽  
Cord Injury ◽  
Biomarkers Of Oxidative Stress

Abstract The successful clinical management of spinal cord injury (SCI) is still a unmet medical need. Despite advances in novel therapeutics, the multifactorial etiology of SCI still poses significant challenge to the mankind. Thus, in the present study, we intend to scrutinize the protective effect of Boldine (BOL), an alkaloid obtained from the boldo tree against experimental spinal cord injury. The effect of BOL was investigated on locomotor function of rats with various biomarkers of oxidative stress (MDA, SOD and GSH), inflammation (TNF-α, IL-1β and IL-6), and apoptosis. Results suggest that BOL showed improvement in locomotor function (on BBB scale) of rats with does-dependent reduction in oxidative stress and inflammation. It also reduces neuronal apoptosis in flow cytometry experiment. The study successfully demonstrated the possible clinical utility of BOL against SCI.

Vasopressor support in managing acute spinal cord injury: current knowledge

2019 ◽  
Vol 63 (3) ◽  
Author(s):  
John K. Yue ◽  
Rachel E. Tsolinas ◽  
John F. Burke ◽  
Hansen Deng ◽  
Pavan S. Upadhyayula ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Current Knowledge ◽  
Acute Spinal Cord Injury ◽  
Vasopressor Support ◽  
Cord Injury
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