scholarly journals Upregulation of CD271 transcriptome in breast cancer promotes cell survival via NFκB pathway

2021 ◽  
Author(s):  
Nabiha Bashir ◽  
Mehreen Ishfaq ◽  
Kehkashan Mazhar ◽  
Jahangir Sarwar Khan ◽  
Ramla Shahid
Keyword(s):  
Breast Cancer ◽  
Cell Survival ◽  
Nfκb Pathway

scholarly journals lincRNA-RP11400K9.4 Regulates Cell Survival and Migration of Breast Cancer Cells

2020 ◽  
Vol 17 (6) ◽  
pp. 769-779
Author(s):  
MIGUEL A. FERNÁNDEZ-ROJAS ◽  
JORGE MELENDEZ-ZAJGLA ◽  
VILMA MALDONADO LAGUNAS
Keyword(s):  
Breast Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
And Migration

scholarly journals Osteoblast-Derived Paracrine and Juxtacrine Signals Protect Disseminated Breast Cancer Cells from Stress

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1366
Author(s):  
Russell Hughes ◽  
Xinyue Chen ◽  
Natasha Cowley ◽  
Penelope D. Ottewell ◽  
Rhoda J. Hawkins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Accessory Cell ◽  
Cancer Cell Survival

Metastatic breast cancer in bone is incurable and there is an urgent need to develop new therapeutic approaches to improve survival. Key to this is understanding the mechanisms governing cancer cell survival and growth in bone, which involves interplay between malignant and accessory cell types. Here, we performed a cellular and molecular comparison of the bone microenvironment in mouse models representing either metastatic indolence or growth, to identify mechanisms regulating cancer cell survival and fate. In vivo, we show that regardless of their fate, breast cancer cells in bone occupy niches rich in osteoblastic cells. As the number of osteoblasts in bone declines, so does the ability to sustain large numbers of breast cancer cells and support metastatic outgrowth. In vitro, osteoblasts protected breast cancer cells from death induced by cell stress and signaling via gap junctions was found to provide important juxtacrine protective mechanisms between osteoblasts and both MDA-MB-231 (TNBC) and MCF7 (ER+) breast cancer cells. Combined with mathematical modelling, these findings indicate that the fate of DTCs is not controlled through the association with specific vessel subtypes. Instead, numbers of osteoblasts dictate availability of protective niches which breast cancer cells can colonize prior to stimulation of metastatic outgrowth.

Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Are Expressed in Breast Cancer and Can Be Targeted to Inhibit Tumor Cell Survival

2011 ◽  
Vol 17 (7) ◽  
pp. 1741-1752 ◽  
Author(s):  
Elsa Vanhecke ◽  
Eric Adriaenssens ◽  
Stéphanie Verbeke ◽  
Samuel Meignan ◽  
Emmanuelle Germain ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cell ◽  
Cell Survival ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Tumor Cell Survival

scholarly journals Preferential Dependence of Breast Cancer Cells versus Normal Cells on Integrin-Linked Kinase for Protein Kinase B/Akt Activation and Cell Survival

2006 ◽  
Vol 66 (1) ◽  
pp. 393-403 ◽  
Author(s):  
Armelle A. Troussard ◽  
Paul C. McDonald ◽  
Elizabeth D. Wederell ◽  
Nasrin M. Mawji ◽  
Nolan R. Filipenko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Cell Survival ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Protein Kinase B ◽  
Normal Cells ◽  
Akt Activation ◽  
Integrin Linked Kinase

scholarly journals CRBP suppresses breast cancer cell survival and anchorage-independent growth

Oncogene ◽  
2001 ◽  
Vol 20 (50) ◽  
pp. 7413-7419 ◽  
Author(s):  
Yuvarani S Kuppumbatti ◽  
Brent Rexer ◽  
Shigeo Nakajo ◽  
Kazuyasu Nakaya ◽  
Rafael Mira-y-Lopez
Keyword(s):  
Breast Cancer ◽  
Cell Survival ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Anchorage Independent Growth ◽  
Cancer Cell Survival

scholarly journals Estrogen as Jekyll and Hyde: regulation of cell death

F1000Research ◽  
2014 ◽  
Vol 3 ◽  
pp. 161 ◽  
Author(s):  
Wen Zhou ◽  
Xiaoxia Zhu
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Breast Cancer Cells ◽  
Breast Cancer Patients ◽  
Physiological Level ◽  
Cancer Cell Death ◽  
Er Positive ◽  
Nfκb Pathway ◽  
Opinion Article ◽  
Positive Breast Cancer

Sustained estrogenic exposure increases the risk and/or the progression of various cancers, including those of the breast, endometrium and ovary. Unexpectedly, physiological level of estrogen together with a novel IKKα inhibitor BAY11-7082 could effectively induce cell apoptosis in ER-positive breast cancer cells, suggesting combining estrogen with IKKα inhibition may be beneficial for breast cancer patients. This opinion article touches upon the dual role estrogen played in inducing cancer cell death and asks whether use of estrogen in combination with IKKα-targeted therapy would be possible reconsider the newly identified crosstalk between ER and NFκB pathway which can be utilized to switch the effects of estrogen on cell death.

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