scholarly journals Induction of estrogen receptor β-mediated autophagy sensitizes breast cancer cells to TAD1822-7, a novel biphenyl urea taspine derivative

2021 ◽  
Author(s):  
Qi Su ◽  
Qing Wu ◽  
Kun Chen ◽  
Jingjing Wang ◽  
Ammar Sarwar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Β

scholarly journals Agonists and knockdown of estrogen receptor β differentially affect invasion of triple-negative breast cancer cells in vitro

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Susanne Schüler-Toprak ◽  
Julia Häring ◽  
Elisabeth C. Inwald ◽  
Christoph Moehle ◽  
Olaf Ortmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Estrogen Receptor Β

Knockdown of PTEN decreases expression of estrogen receptor β and tamoxifen sensitivity of human breast cancer cells

Steroids ◽  
2020 ◽  
Vol 153 ◽  
pp. 108521
Author(s):  
Oliver Treeck ◽  
Susanne Schüler-Toprak ◽  
Maciej Skrzypczak ◽  
Florian Weber ◽  
Olaf Ortmann
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Β ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Tamoxifen Sensitivity

scholarly journals Induction of Estrogen Receptor β-mediated Autophagy Sensitizes Breast Cancer Cells to TAD1822-7, a Novel Biphenyl Urea Taspine Derivative

2021 ◽  
Author(s):  
Qi Su ◽  
Qing Wu ◽  
Kun Chen ◽  
Jingjing Wang ◽  
Ammar Sarwar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Annexin V ◽  
Female Breast Cancer ◽  
Estrogen Receptor Β ◽  
Inhibitory Effects ◽  
Insight Into

Abstract Female breast cancer has become the most commonly diagnosed cancer worldwide. As a tumor suppressor, estrogen receptor β (ERβ) is a potential target for breast cancer therapy. TAD1822-7 was evaluated for ERβ-mediated autophagy and cell death using cell proliferation assay, Annexin V/PI staining, immunofluorescence, western blotting and hypoxia cell models. TAD1822-7 upregulated ERβ causing cell death and induced mitochondrial dysfunction and autophagy companied with mitochondrial located ERβ. Enhanced levels of LC3-II and p62 indicated that TAD1822-7 blocked the late-stage autolysosome formation, leading to cell death. Mechanistically, TAD1822-7-induced cell death was mediated by PI3K/AKT signaling pathways. Moreover, TAD1822-7 modulated HIF functions and autophagy via the inhibition of HIF-1β in the context of hypoxia-induced autophagy. TAD1822-7 inhibited hypoxia-inducted autophagy and PI3K/AKT pathway. These findings provide new insight into the mechanism underlying the inhibitory effects of TAD1822-7 via ERβ-mediated pathways in breast cancer cells.

Expression of estrogen receptor β increases integrin α1 and integrin β1 levels and enhances adhesion of breast cancer cells

2010 ◽  
Vol 222 (1) ◽  
pp. 156-167 ◽  
Author(s):  
Karolina Lindberg ◽  
Anders Ström ◽  
John G. Lock ◽  
Jan-Åke Gustafsson ◽  
Lars-Arne Haldosén ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Β ◽  
Integrin Β1

The presence of Estrogen Receptor β modulates the response of breast cancer cells to therapeutic agents

2015 ◽  
Vol 66 ◽  
pp. 85-94 ◽  
Author(s):  
Daniel Gabriel Pons ◽  
Margalida Torrens-Mas ◽  
Mercedes Nadal-Serrano ◽  
Jorge Sastre-Serra ◽  
Pilar Roca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Therapeutic Agents ◽  
Estrogen Receptor Β
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