Killing Activity of Micafungin Against Candida albicans, C. dubliniensis and Candida africana in the Presence of Human Serum

2017 ◽  
Vol 182 (11-12) ◽  
pp. 979-987 ◽  
Author(s):  
Renátó Kovács ◽  
Qasem Saleh ◽  
Aliz Bozó ◽  
Zoltán Tóth ◽  
Rudolf Gesztelyi ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Human Serum ◽  
Killing Activity ◽  
Candida Africana

scholarly journals Extreme diversification driven by parallel events of massive loss of heterozygosity in the hybrid lineage of Candida albicans

Genetics ◽  
2020 ◽  
Vol 217 (2) ◽  
Author(s):  
Verónica Mixão ◽  
Ester Saus ◽  
Teun Boekhout ◽  
Toni Gabaldón
Keyword(s):  
Candida Albicans ◽  
Loss Of Heterozygosity ◽  
Type Strain ◽  
Taxonomic Classification ◽  
Hybrid Origin ◽  
Genomic Analyses ◽  
Candida Africana

Abstract Candida albicans is the most commonly reported species causing candidiasis. The taxonomic classification of C. albicans and related lineages is controversial, with Candida africana (syn. C. albicans var. africana) and Candida stellatoidea (syn. C. albicans var. stellatoidea) being considered different species or C. albicans varieties depending on the authors. Moreover, recent genomic analyses have suggested a shared hybrid origin of C. albicans and C. africana, but the potential parental lineages remain unidentified. Although the genomes of C. albicans and C. africana have been extensively studied, the genome of C. stellatoidea has not been sequenced so far. In order to get a better understanding of the evolution of the C. albicans clade, and to assess whether C. stellatoidea could represent one of the unknown C. albicans parental lineages, we sequenced C. stellatoidea type strain (CBS 1905). This genome was compared to that of C. albicans and of the closely related lineage C. africana. Our results show that, similarly to C. africana, C. stellatoidea descends from the same hybrid ancestor as other C. albicans strains and that it has undergone a parallel massive loss of heterozygosity.

scholarly journals Distribution, antifungal susceptibility pattern and intra-Candida albicans species complex prevalence of Candida africana: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237046 ◽  
Author(s):  
Sanaz Aghaei Gharehbolagh ◽  
Bahareh Fallah ◽  
Alireza Izadi ◽  
Zeinab Sadeghi Ardestani ◽  
Pooneh Malekifar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Candida Albicans ◽  
Species Complex ◽  
Meta Analysis ◽  
Antifungal Susceptibility ◽  
Susceptibility Pattern ◽  
Candida Africana

scholarly journals A role for complement receptor-like molecules in iron acquisition by Candida albicans.

1992 ◽  
Vol 175 (6) ◽  
pp. 1643-1651 ◽  
Author(s):  
M A Moors ◽  
T L Stull ◽  
K J Blank ◽  
H R Buckley ◽  
D M Mosser
Keyword(s):  
Candida Albicans ◽  
Human Serum ◽  
Iron Acquisition ◽  
Alternative Pathway ◽  
Protoporphyrin Ix ◽  
Surface Proteins ◽  
Pathogenic Potential ◽  
Opportunistic Fungal Pathogen ◽  
Iron Binding Proteins ◽  
Type 3

Candida albicans, an opportunistic fungal pathogen of humans, is dependent upon iron for growth. Consequently, human serum inhibits C. albicans growth due to the presence of high affinity iron-binding proteins that sequester serum iron, making it unavailable for use by the organism. We report that in the inhibitory environment of human serum, the growth of C. albicans can be restored by the addition of exogenous hemoglobin or heme, but not by protoporphyrin IX, the heme precursor that does not contain iron. We further report that C. albicans can utilize cell surface proteins that are homologues of the mammalian complement receptors (CR) to rosette complement-coated red blood cells (RBC) and obtain RBC-derived iron for growth. The ability of Candida to acquire RBC-derived iron under these conditions is dependent upon Candida-RBC rosetting mediated by CR-like molecules. Unopsonized RBC do not support Candida growth in serum, and restoration of Candida growth in serum by complement-opsonized RBC is inhibited by monoclonal antibodies to the human CR type 3 (CR3). In addition, activation of the human alternative pathway of complement by Candida leads to "bystander" deposition of C3 fragments on the surface of autologous, unopsonized RBC, generating the ligands necessary for Candida-RBC rosetting. These results suggest that C. albicans has evolved a unique strategy for acquiring iron from the host, which exploits the host complement system, and which may contribute to the pathogenic potential of the organism.

Effect of 50% human serum on the killing activity of micafungin against eight Candida species using time–kill methodology

2012 ◽  
Vol 73 (4) ◽  
pp. 338-342 ◽  
Author(s):  
Richárd Földi ◽  
Judit Szilágyi ◽  
Gábor Kardos ◽  
Réka Berényi ◽  
Renátó Kovács ◽  
...  
Keyword(s):  
Human Serum ◽  
Candida Species ◽  
Killing Activity ◽  
Time Kill

scholarly journals Human Serum Promotes Candida albicans Biofilm Growth and Virulence Gene Expression on Silicone Biomaterial

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62902 ◽  
Author(s):  
Yuthika Hemamala Samaranayake ◽  
Becky P. K. Cheung ◽  
Joyce Y. Y. Yau ◽  
Shadow K. W. Yeung ◽  
Lakshman P. Samaranayake
Keyword(s):  
Gene Expression ◽  
Candida Albicans ◽  
Human Serum ◽  
Virulence Gene ◽  
Biofilm Growth ◽  
Virulence Gene Expression

scholarly journals Molecular Characterization ofCandida africanain Genital Specimens in Shanghai, China

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Yang Hu ◽  
Aihua Yu ◽  
Xiangming Chen ◽  
Guojiang Wang ◽  
Xiaobo Feng
Keyword(s):  
Candida Albicans ◽  
Sexually Transmitted Diseases ◽  
Amphotericin B ◽  
Molecular Characterization ◽  
Vaginal Swab ◽  
Vulvovaginal Candidiasis ◽  
Sexually Transmitted ◽  
Candida Africana

Candida africana, an emerging yeast pathogen, is closely related toCandida albicansand most commonly involved in vulvovaginal candidiasis (VVC). However, its prevalence in candidal balanoposthitis is still unclear. In this study, the prevalence ofC. africanain both candidal balanoposthitis and VVC in a sexually transmitted diseases (STD) clinic in Shanghai, China, was analyzed, and the molecular characterization and susceptible profiles ofC. africanaisolates were investigated. As results,C. africanawas only isolated in 5 out of 79 (6.3%) cases of candidal balanoposthitis rather than cases with vulvovaginal candidiasis. Among them, 4 out of 5 isolates share the same genotype of DST 782 with an isolate from vaginal swab in Japan published previously. AllC. africanaisolates were susceptible to amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and micafungin.

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