Selective killing of cancer cells by iron oxide nanoparticles mediated through reactive oxygen species via p53 pathway

2012 ◽  
Vol 15 (1) ◽  
Author(s):  
Maqusood Ahamed ◽  
Hisham A. Alhadlaq ◽  
M. A. Majeed Khan ◽  
Mohd. Javed Akhtar
Keyword(s):  
Reactive Oxygen Species ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
P53 Pathway

scholarly journals Activatable Superparamagnetic Iron Oxide Nanoparticles Scavenge Reactive Oxygen Species in Macrophages and Endothelial Cells

2020 ◽  
Author(s):  
Chukwuazam Nwasike ◽  
Eunsoo Yoo ◽  
Erin Purr ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species

<p>This study centers around diagnostic medicine, and severity staging of inflammatory diseases. Previously, we showed that complexation of PEG and Poly(gallol) on superparamagnetic iron oxide nanoparticles turn OFF the MRI contrasting ability of the nanoparticle. However, in the presence of reactive oxygen species, the contrast agent will turn ON. In this article, for the first time, we provide evidence that our MRI contrast agent is sensitive to physiologically relevant ROS and induces antioxidant activity on immune and endothelial cells. This study provides initial evidence of IPC-SPIOs cellular ROS sensitivity and potential activatable properties in biological conditions.</p>

scholarly journals Accelerated generation of free radicals by iron oxide nanoparticles in the presence of an alternating magnetic field

RSC Advances ◽  
2015 ◽  
Vol 5 (24) ◽  
pp. 18888-18893 ◽  
Author(s):  
Robert J. Wydra ◽  
Catherine E. Oliver ◽  
Kimberly W. Anderson ◽  
Thomas D. Dziubla ◽  
J. Zach Hilt
Keyword(s):  
Magnetic Field ◽  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles ◽  
Oxygen Species

The catalytic generation of reactive oxygen species from the surface of iron oxide nanoparticles is enhanced through the activated heating with exposure to an alternating magnetic field.

scholarly journals Activatable Superparamagnetic Iron Oxide Nanoparticles Scavenge Reactive Oxygen Species in Macrophages and Endothelial Cells

2020 ◽  
Author(s):  
Chukwuazam Nwasike ◽  
Eunsoo Yoo ◽  
Erin Purr ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species

<p>This study centers around diagnostic medicine, and severity staging of inflammatory diseases. Previously, we showed that complexation of PEG and Poly(gallol) on superparamagnetic iron oxide nanoparticles turn OFF the MRI contrasting ability of the nanoparticle. However, in the presence of reactive oxygen species, the contrast agent will turn ON. In this article, for the first time, we provide evidence that our MRI contrast agent is sensitive to physiologically relevant ROS and induces antioxidant activity on immune and endothelial cells. This study provides initial evidence of IPC-SPIOs cellular ROS sensitivity and potential activatable properties in biological conditions.</p>

scholarly journals Activatable superparamagnetic iron oxide nanoparticles scavenge reactive oxygen species in macrophages and endothelial cells

RSC Advances ◽  
2020 ◽  
Vol 10 (68) ◽  
pp. 41305-41314
Author(s):  
Chukwuazam Nwasike ◽  
Eunsoo Yoo ◽  
Erin Purr ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Intracellular Ros

Complexed IPC-SPIOs scavenge intracellular ROS after internalization.

Linalool Suppresses Proliferation and Promotes Apoptosis in Gastric Cancer Cells via Activation of Reactive Oxygen Species-Mediated P53 Pathway

2020 ◽  
Vol 18 (4) ◽  
pp. 325-330
Author(s):  
Haitao Ding ◽  
Zhijun Han ◽  
Jie Cao ◽  
Xiuli Yang
Keyword(s):  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Gastric Cancer Cells ◽  
P53 Pathway ◽  
Dose Dependent Fashion ◽  
Markers Of Oxidative Stress ◽  
Cancer Agent

The role of linalool in gastric cancer has been examined by measuring its effects on cell cytotoxicity, apoptosis, and accumulation of reactive oxygen species as well as markers of oxidative stress. In a dose-dependent fashion, linalool suppressed the viability of gastric cancer cells and increased accumulation of reactive oxygen species with a concomitant increase in malondialdehyde, cleavage of caspase 3 and p53 and decrease in superoxide dismutase and glutathione peroxidase. N-acetyl cysteine, a scavenger of reactive oxygen species reduced the effects of linalool on gastric cancer cells. In conclusion, linalool suppresses cell viability and promotes cell apoptosis of gastric cancer cells via activation of reactive oxygen species-mediated p53 pathway suggesting that linalool might serve as a potential anti-cancer agent.

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