Management and survival trends for adult patients with malignant gliomas in the setting of multiple primary tumors: a population based analysis

e16138 Background: Carcinosarcoma of the bladder are rare; As a result, few studies of carcinosarcoma of the bladder have included sufficient number of patients to define their natural history and to determine the factors that impact survival. The objective of this study was to examine the epidemiology, natural history, and prognostic factors that affect the survival for carcinosarcoma of the bladder by using population-based registries. Methods: The Surveillance, Epidemiology, and End Results (SEER) Program database (1973–2004) was used to identify cases of carcinosarcoma of the bladder by tumor site and histology codes. The association between clinical and demographic characteristics and survival of carcinosarcoma of the bladder was examined. Results: A total of 221 cases of histology confirmed carcinosarcoma of the bladder were identified, this account for approximately 0.11% of primary bladder tumors during same period. By using linked population files, we calculated the incidence of carcinosarcoma of the bladder as a rate 0.22 per 100,000 per year, age-adjusted to year 2000 U.S. standard population. Median age of all patients were 75 years (range 41–96). In about 40% of study population, more than one or multiple primary were also indentified. Majority of (212, 95.9 %) patients received cancer directed surgery. For survival analyses, we excluded the cases that were identified at autopsy or on the basis of death certificates only and the patients have more than one primary. Total 132 patients were included in survival analysis. The median overall survival for all cases was 9 months (range 6–12 months). In multivariate analysis, only tumor stage was found to be significant prognostic factors for disease-specific survival. Conclusions: Carcinosarcoma of the bladder are rare tumors that are challenging, the survival is poor even in patients underwent surgical resection. Better therapy is needed to improve patient's outcome. A significant fraction of carcinosarcoma patients are actually affected by multiple primary tumors, the potential association between carcinosarcoma and other neoplasms remain to be investigated. No significant financial relationships to disclose.

Download Full-text

Multiple Primary Tumors in a Family with Li-Fraumeni Syndrome with a TP53 Germline Mutation Identified by Next-Generation Sequencing

The International Journal of Biological Markers ◽

10.5301/jbm.5000227 ◽

2016 ◽

Vol 31 (4) ◽

pp. 461-465 ◽

Cited By ~ 2

Author(s):

Valentina Zampiga ◽

Rita Danesi ◽

Gianluca Tedaldi ◽

Michela Tebaldi ◽

Ilaria Cangini ◽

...

Keyword(s):

Next Generation Sequencing ◽

Genetic Analysis ◽

Germline Mutation ◽

Tp53 Mutation ◽

Primary Tumors ◽

Li Fraumeni Syndrome ◽

Multiple Primary Tumors ◽

Targeted Ngs ◽

Multiple Primary ◽

Generation Sequencing

Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder occurring at a young age that predisposes individuals to multiple forms of cancer and to a heterogeneous spectrum of malignancies. We describe the clinical history of a patient who had 5 primary malignant cancers and a familiar history consistent with LFS. We analyzed the genomic DNA of the proband and her relatives by next-generation sequencing (NGS) technology using an enrichment protocol for the simultaneous sequencing of 94 genes involved in hereditary cancers. Genetic analysis of the proband revealed a TP53 germline mutation in exon 5 determining a nucleotide alteration at codon 175 (R175H), a hot spot mutation site related to LFS and a reported pathogenic mutation. The proband daughter's and brother's DNA did not carry the TP53 mutation but they had some rare variants in common with the proband, in addition to other variants with a still unclear role. In conclusion, we identified a TP53 mutation in a patient with multiple primary tumors and a family history characterized by a severe susceptibility to cancer. The genetic analysis by targeted NGS led to the identification of the genetic background and to the exclusion of a cancer risk for the family members. Targeted NGS represents an efficient approach for the identification of mutations in families with a heterogeneous phenotype.

Download Full-text

Bilateral symmetric Merkel cell carcinomas of the dorsal hands: multiple primary tumors or early metastasis?

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20213352 ◽

2021 ◽

Vol 7 (5) ◽

pp. 730

Author(s):

Jennifer Seyffert ◽

Alysa Herman ◽

Brian Katz ◽

Daniel Rivlin

Keyword(s):

Viral Infection ◽

Cell Carcinoma ◽

Neuroendocrine Tumor ◽

Merkel Cell ◽

Unique Case ◽

Primary Tumors ◽

Solitary Nodule ◽

Multiple Primary Tumors ◽

Multiple Primary ◽

Head Neck

<p>Merkel cell carcinoma (MCC) is an aggressive and uncommon neuroendocrine tumor which clinically presents as a rapidly growing solitary nodule or plaque located in sun exposed areas on the head, neck, and extremities. Merkel cell carcinomas can be UV-induced or result from viral infection with the Merkel cell polyomavirus (MCV). We present a unique case of bilateral symmetric Merkel cell carcinomas located on the dorsal hands and briefly discuss options for genomic investigation to delineate if the tumors are multiple primary tumors or result of metastatic disease.</p>

Download Full-text