Signet Ring Cell Adenoma Thyroid – A Case Report

Signet ring cell adenoma is a rare thyroid neoplasm which usually present as a solitary nodule. Histopathologically it can very well be mistaken for a metastatic signet ring cell lesion, as both of them shows cells with intracytoplasmic vacuole and eccentrically pushed nucleus. The intracytoplasmic vacuole in signet ring cell adenoma stain positive for thyroglobulin which help in confirming the diagnosis. Here we describe a case of signet ring cell adenoma of thyroid in a 46-year-old female with its cytological, histological and immunohistochemical features.

A case report on placental chorioangioma

Chorioangioma is the term used to describe an abnormal proliferation of vessels arising from chorionic tissue, which is most commonly observed in the third, and less frequently in the second trimester of pregnancy as a solitary nodule or, less commonly, as multiple nodules. We here report a case of placental chorioangioma which presented as a case of preterm labour. 21 year old primigravida presented to us at 26 weeks of gestation with history of PV leak and pain in abdomen. Ultrasound showed a single live foetus corresponding to 24-26 weeks of gestation with amniotic fluid index (AFI): 5 cm (oligohydramnios) there was evidence of 58×42 mm heterogeneously hypoechoic lesion noted over placenta likely s/o chorioangioma. Patient went into spontaneous preterm labour on day 5 and delivered vaginally. Placenta weighted 700 gm. A globular mass of size 6×7 cm was attached to foetal surface of placenta with a pedicle with confirmed the finding of ultrasonography. Placental chorioangioma is associated with high rates of perinatal complications. Most complications may appear early and delivery is problematic due to prematurity. Thus better prenatal investigations and regular follow up is required for early diagnosis and treatment.

Pyogenic Granuloma: A Case Report

Pyogenic granuloma is a type of inflammatory hyperplasia of the oral mucosa and skin that occurs commonly. Histopathologically, it mimics an angiomatous lesion instead of granulomatous disease. These lesions generally appear as a sessile papule or solitary nodule and may have a smooth or lobulated surface clinically. These granulomas present in a variety of sizes, ranging from a few millimeters to several centimeters. About 75% of the pyogenic granulomas of the oral cavity are associated with the gingiva. In this case report a 31 years old female presented in the department of oral and maxillofacial surgery with the complaint of abnormal growth of gingiva in maxillary anterior region. The patient was diagnosed with the pyogenic granuloma (pregnancy tumor), which had developed in the second trimester of her pregnancy. Surgical excision was done to remove the lesion.

Bilateral symmetric Merkel cell carcinomas of the dorsal hands: multiple primary tumors or early metastasis?

<p>Merkel cell carcinoma (MCC) is an aggressive and uncommon neuroendocrine tumor which clinically presents as a rapidly growing solitary nodule or plaque located in sun exposed areas on the head, neck, and extremities. Merkel cell carcinomas can be UV-induced or result from viral infection with the Merkel cell polyomavirus (MCV). We present a unique case of bilateral symmetric Merkel cell carcinomas located on the dorsal hands and briefly discuss options for genomic investigation to delineate if the tumors are multiple primary tumors or result of metastatic disease.</p>

Diagnostic accuracy of fine needle aspiration cytology in neoplasms of solitary nodule in thyroid gland: a retrospective study

Background: Common endocrine disorders like thyroid nodule may represent thyroid neoplasm either benign or malignant and are important to be diagnosed as they may progress and lead to thyroid dysfunction. Fine needle aspiration cytology (FNAC) has emerged as an economic, rapid, effective, simple and accurate strategy for diagnosing neoplastic thyroid nodules. The basic aim of the current investigation was to evaluate the diagnostic accuracy of FNAC in neoplasms of solitary thyroid nodules.Methods: Current investigation was a retrospective diagnostic test evaluation study conducted on 60 patients who underwent total thyroidectomy for solitary nodule for a duration of one year. Routine blood investigation, thyroid function test, FNAC, chest X-ray, indirect laryngoscopy and ultrasound scanning of neck were done for all the patients. Collected data was coded and entered in excel sheets and was statistically analyzed using SPSS.Results: Mean age of the participating patients was 45.51±7.2 years and age range was 24 to 68 years. Female patients were observed to be more than male patients. In majority of the patients duration of nodule was less than or equal to one to three years. Maximum number of patients underwent either total or hemi thyroidectomy. FNAC diagnostic findings revealed patients with NCG, FN, LT, PC and MC. The results of FNAC findings resembled and were supported by HPR findings.Conclusions: Current investigation findings revealed that fine needle aspiration cytology can be considered as potential, accurate, rapid and efficient diagnostic technique for rapid primary investigation of neoplasms of solitary nodules in thyroid gland.