Cyclosporine A Reduces Dendritic Outgrowth of Neuroblasts in the Subgranular Zone of the Dentate Gyrus in C57BL/6 Mice

Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively investigate adult neural stem cell origin and heterogeneity.

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Subgranular Zone of the Dentate Gyrus of Young Rabbits As a Secondary Matrix

Developmental Neuroscience ◽

10.1159/000112694 ◽

1982 ◽

Vol 5 (4) ◽

pp. 345-358 ◽

Cited By ~ 61

Author(s):

G. Guéneau ◽

A. Privat ◽

J. Drouet ◽

L. Court

Keyword(s):

Dentate Gyrus ◽

Subgranular Zone

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Comparative studies on the neuronal differentiation in the subgranular zone of dentate gyrus between adult and aged gerbils after transient forebrain ischemia

Neuroscience Research ◽

10.1016/j.neures.2010.07.1636 ◽

2010 ◽

Vol 68 ◽

pp. e369

Author(s):

Dae Young Yoo ◽

In Koo Hwang ◽

Jung Hoon Choi ◽

Ki-Yeon Yoo ◽

Choon Hyun Lee ◽

...

Keyword(s):

Dentate Gyrus ◽

Neuronal Differentiation ◽

Comparative Studies ◽

Subgranular Zone ◽

Forebrain Ischemia ◽

Transient Forebrain Ischemia

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Fluctuations in cellular proliferation across the light/dark cycle in the subgranular zone of the dentate gyrus in the adult male Syrian hamster

Neuroscience Letters ◽

10.1016/j.neulet.2010.02.039 ◽

2010 ◽

Vol 473 (3) ◽

pp. 192-195 ◽

Cited By ~ 7

Author(s):

Jeannie Marie Smith ◽

Aaron Hechtman ◽

Jennifer Swann

Keyword(s):

Dentate Gyrus ◽

Adult Male ◽

Syrian Hamster ◽

Cellular Proliferation ◽

Subgranular Zone ◽

Dark Cycle

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The Coexpression of Reelin and Neuronal Nitric Oxide Synthase in a Subpopulation of Dentate Gyrus Neurons Is Downregulated in Heterozygous Reeler Mice

Neural Plasticity ◽

10.1155/2010/130429 ◽

2010 ◽

Vol 2010 ◽

pp. 1-10 ◽

Cited By ~ 8

Author(s):

Raquel Romay-Tallón ◽

Iria G. Dopeso-Reyes ◽

April L. Lussier ◽

Lisa E. Kalynchuk ◽

Hector J. Caruncho

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Dentate Gyrus ◽

Matrix Protein ◽

Molecular Layer ◽

Neuronal Nitric Oxide Synthase ◽

Stratum Radiatum ◽

Extracellular Matrix Protein ◽

Subgranular Zone ◽

Oxide Synthase

Reelin is an extracellular matrix protein expressed in several interneuron subtypes in the hippocampus and dentate gyrus. Neuronal nitric oxide synthase (nNOS) is also expressed by interneurons in these areas. We investigated whether reelin and nNOS are co-localized in the same population of hippocampal interneurons, and whether this colocalization is altered in the heterozygous reeler mouse. We found colocalization of nNOS in reelin-positive cells in the CA1 stratum radiatum and lacunosum moleculare, the CA3 stratum radiatum, and the dentate gyrus subgranular zone, molecular layer, and hilus. In heterozygous reeler mice, the colocalization of nNOS in reelin-positive cells was significantly decreased only in the subgranular zone and molecular layer. The coexpression of reelin and nNOS in several hippocampal regions suggests that reelin and nNOS may work synergistically to promote glutamatergic function, and the loss of this coexpression in heterozygous reeler mice may underlie some of the behavioral deficits observed in these animals.

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