scholarly journals Radial glial cells in the adult dentate gyrus: what are they and where do they come from?

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 277 ◽  
Author(s):  
Daniel A. Berg ◽  
Allison M. Bond ◽  
Guo-li Ming ◽  
Hongjun Song
Keyword(s):  
Stem Cells ◽  
Dentate Gyrus ◽  
Radial Glia ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Subgranular Zone ◽  
Adult Neural Stem Cell ◽  
Radial Glial Cells ◽  
Embryonic Origin ◽  
Radial Glial

Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively investigate adult neural stem cell origin and heterogeneity.

scholarly journals Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells

Neuron ◽  
2017 ◽  
Vol 95 (2) ◽  
pp. 309-325.e6 ◽  
Author(s):  
Xiao-Ling Hu ◽  
Guo Chen ◽  
Sanguo Zhang ◽  
Jiangli Zheng ◽  
Jun Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Glial Cells ◽  
Radial Glial Cells ◽  
Embryonic Origin ◽  
Radial Glial

scholarly journals Zika virus has oncolytic activity against glioblastoma stem cells

2017 ◽  
Vol 214 (10) ◽  
pp. 2843-2857 ◽  
Author(s):  
Zhe Zhu ◽  
Matthew J. Gorman ◽  
Lisa D. McKenzie ◽  
Jiani N. Chai ◽  
Christopher G. Hubert ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Brain Cancer ◽  
Zika Virus ◽  
Oncolytic Virus ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Neural Cells ◽  
Glioblastoma Stem Cells ◽  
Oncolytic Activity

Glioblastoma is a highly lethal brain cancer that frequently recurs in proximity to the original resection cavity. We explored the use of oncolytic virus therapy against glioblastoma with Zika virus (ZIKV), a flavivirus that induces cell death and differentiation of neural precursor cells in the developing fetus. ZIKV preferentially infected and killed glioblastoma stem cells (GSCs) relative to differentiated tumor progeny or normal neuronal cells. The effects against GSCs were not a general property of neurotropic flaviviruses, as West Nile virus indiscriminately killed both tumor and normal neural cells. ZIKV potently depleted patient-derived GSCs grown in culture and in organoids. Moreover, mice with glioblastoma survived substantially longer and at greater rates when the tumor was inoculated with a mouse-adapted strain of ZIKV. Our results suggest that ZIKV is an oncolytic virus that can preferentially target GSCs; thus, genetically modified strains that further optimize safety could have therapeutic efficacy for adult glioblastoma patients.

Topical Review: Neuronal Migration in Cortical Development

2004 ◽  
Vol 19 (3) ◽  
pp. 274-279
Author(s):  
Shigeaki Kanatani ◽  
Hidenori Tabata ◽  
Kazunori Nakajima
Keyword(s):  
Neuronal Migration ◽  
Radial Glia ◽  
Asymmetric Cell Division ◽  
Time Lapse ◽  
Radial Glial Cells ◽  
Daughter Cells ◽  
Radial Glial ◽  
Time Lapse Imaging ◽  
Mitotic Behavior

Cortical formation in the developing brain is a highly complicated process involving neuronal production (through symmetric or asymmetric cell division) interaction of radial glia with neuronal migration, and multiple modes of neuronal migration. It has been convincingly demonstrated by numerous studies that radial glial cells are neural stem cells. However, the processes by which neurons arise from radial glia and migrate to their final destinations in vivo are not yet fully understood. Recent studies using time-lapse imaging of neuronal migration are giving investigators an increasingly more detailed understanding of the mitotic behavior of radial glia and the migrating behavior of their daughter cells. In this review, we describe recent progress in elucidating neuronal migration in brain formation and how neuronal migration is disturbed by mutations in genes that control this process. ( J Child Neurol 2005;20:274—279).

scholarly journals The Ventral Hippocampus Is the Embryonic Origin for Adult Neural Stem Cells in the Dentate Gyrus

Neuron ◽  
2013 ◽  
Vol 78 (4) ◽  
pp. 658-672 ◽  
Author(s):  
Guangnan Li ◽  
Li Fang ◽  
Gloria Fernández ◽  
Samuel J. Pleasure
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Dentate Gyrus ◽  
Ventral Hippocampus ◽  
Adult Neural Stem Cells ◽  
Embryonic Origin

scholarly journals Direct Reprogramming of Rat Neural Precursor Cells and Fibroblasts into Pluripotent Stem Cells

PLoS ONE ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. e9838 ◽  
Author(s):  
Mi-Yoon Chang ◽  
Dohoon Kim ◽  
Chun-Hyung Kim ◽  
Hoon-Chul Kang ◽  
Eungi Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Direct Reprogramming

scholarly journals Glucocorticoids and Lithium Reciprocally Regulate the Proliferation of Adult Dentate Gyrus-Derived Neural Precursor Cells Through GSK-3β and β-Catenin/TCF Pathway

2008 ◽  
Vol 34 (3) ◽  
pp. 805-815 ◽  
Author(s):  
Shuken Boku ◽  
Shin Nakagawa ◽  
Takahiro Masuda ◽  
Hiroyuki Nishikawa ◽  
Akiko Kato ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Gsk 3Β
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