Induction of cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus by aqueous extract from Platycodon grandiflorum in middle-aged mice

2008 ◽  
Vol 444 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Ki-Yeon Yoo ◽  
Ok Kyu Park ◽  
In Koo Hwang ◽  
Hua Li ◽  
Shi Yong Ryu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Aqueous Extract ◽  
Subgranular Zone ◽  
Middle Aged ◽  
Platycodon Grandiflorum ◽  
Aged Mice

Zizyphus Enhances Cell Proliferation and Neuroblast Differentiation in the Subgranular Zone of the Dentate Gyrus in Middle-Aged Mice

2011 ◽  
Vol 14 (3) ◽  
pp. 195-200 ◽  
Author(s):  
In Koo Hwang ◽  
Ki-Yeon Yoo ◽  
Dae Young Yoo ◽  
Jung Hoon Choi ◽  
Choong Hyun Lee ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Subgranular Zone ◽  
Middle Aged ◽  
Aged Mice ◽  
Neuroblast Differentiation

Induction of doublecortin immunoreactive cells in the subgranular zone of dentate gyrus by aqueous extract from Platycodon grandiflorum in ischemic gerbils

2009 ◽  
Vol 65 ◽  
pp. S78
Author(s):  
Young eun Jeon ◽  
Choong Hyun Lee ◽  
Jung Hoon Lee ◽  
Joon Ha Park ◽  
Ok Kyu Park ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Aqueous Extract ◽  
Subgranular Zone ◽  
Platycodon Grandiflorum

Abstract TP104: Post Stroke Depressive-Like Behaviors in Middle-Aged Female Rats is Associated With Gut Dysbiosis and Improved by Mir363-3p

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Courtney Stewart ◽  
Aditya Panta ◽  
Taylor Branyan ◽  
Farida Sohrabji
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Forced Swim Test ◽  
Female Rats ◽  
Middle Aged ◽  
16S Sequencing ◽  
Post Stroke ◽  
Hippocampal Cell ◽  
Affective Behaviors ◽  
Post Stroke Depression

Background: Post-stroke depression (PSD) occurs in one-third of stroke survivors, is more prevalent in women, and negatively impacts quality of life and recovery. Our previous work showed that acyclic middle-aged female rats display depressive behaviors after stroke, and IV treatment with mir363-3p attenuates these behaviors. Serotonin has been implicated in affective behaviors, and loss of this neurotransmitter is also associated with decreased neurogenesis in the hippocampus. The present study determined (a) whether stroke affected tryptophan, a gut metabolite, and precursor for serotonin, and cell proliferation in the hippocampus and (b) whether serum tryptophan levels and hippocampal cell proliferation was restored by mir363-3p. Methods: Ischemic stroke was induced by stereotaxic delivery of endothelin-1 to the MCA of middle-aged female rats. Animals received a single injection of mir363-3p or scrambled oligos 4h after stroke. Depressive-like behaviors were assessed by the Effort-based sucrose consumption test, Social Interaction and Forced Swim Test 3 months after stroke. Blood was collected at termination. Serum tryptophan levels were quantified by ELISA. Bacterial composition was analyzed by 16S sequencing of fecal samples. Ki67 immunohistochemistry was performed on brain tissue collected at termination and quantified within the dentate gyrus by two blind observers. Results: Animals subjected to stroke exhibited depressive-like behaviors and had decreased tryptophan levels as compared to sham treated animals. This is also accompanied by microbiota dysbiosis as measured by an elevated ratio of Firmicutes to Bacteroidetes. Mir363-3p treatment increased tryptophan levels as compared to scrambled controls and were no different from sham (non-stroke) animals. Moreover, miR363-3p treated rats exhibit a significantly more dentate gyrus-specific Ki67 expression a proliferation marker. Conclusions: Together, these data indicate that miR363-3p attenuates post stroke depression via a mechanism that prevents microbiota dysbiosis and increases hippocampal cell proliferation.

scholarly journals N-Acetylmannosamine Improves Object Recognition and Hippocampal Cell Proliferation in Middle-Aged Mice

2012 ◽  
Vol 76 (12) ◽  
pp. 2249-2254 ◽  
Author(s):  
Takefumi KIKUSUI ◽  
Aki SHIMOZAWA ◽  
Aya KITAGAWA ◽  
Miho NAGASAWA ◽  
Kazutaka MOGI ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Object Recognition ◽  
Middle Aged ◽  
Aged Mice ◽  
Hippocampal Cell

(-)-epigallocatechin-3-gallate increases cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus in adult mice

2009 ◽  
Vol 24 (7) ◽  
pp. 1065-1070 ◽  
Author(s):  
Ki-Yeon Yoo ◽  
Jung Hoon Choi ◽  
In Koo Hwang ◽  
Choong Hyun Lee ◽  
Soon Ok Lee ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Dentate Gyrus ◽  
Subgranular Zone ◽  
Adult Mice

scholarly journals A 1-Month Ketogenic Diet Increased Mitochondrial Mass in Red Gastrocnemius Muscle, but not in the Brain or Liver of Middle-Aged Mice

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2533
Author(s):  
Zeyu Zhou ◽  
Jocelyn Vidales ◽  
José A González-Reyes ◽  
Bradley Shibata ◽  
Keith Baar ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Gastrocnemius Muscle ◽  
Left Lobe ◽  
Middle Aged ◽  
Mitochondrial Content ◽  
Mitochondrial Mass ◽  
Aged Mice ◽  
Fractional Area ◽  
Ketogenic Diets ◽  
The Impact

Alterations in markers of mitochondrial content with ketogenic diets (KD) have been reported in tissues of rodents, but morphological quantification of mitochondrial mass using transmission electron microscopy (TEM), the gold standard for mitochondrial quantification, is needed to further validate these findings and look at specific regions of interest within a tissue. In this study, red gastrocnemius muscle, the prefrontal cortex, the hippocampus, and the liver left lobe were used to investigate the impact of a 1-month KD on mitochondrial content in healthy middle-aged mice. The results showed that in red gastrocnemius muscle, the fractional area of both subsarcolemmal (SSM) and intermyofibrillar (IMM) mitochondria was increased, and this was driven by an increase in the number of mitochondria. Mitochondrial fractional area or number was not altered in the liver, prefrontal cortex, or hippocampus following 1 month of a KD. These results demonstrate tissue-specific changes in mitochondrial mass with a short-term KD and highlight the need to study different muscle groups or tissue regions with TEM to thoroughly determine the effects of a KD on mitochondrial mass.

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