scholarly journals Pigment Epithelium-Derived Factor Released by Müller Glial Cells Exerts Neuroprotective Effects on Retinal Ganglion Cells

2012 ◽  
Vol 37 (7) ◽  
pp. 1524-1533 ◽  
Author(s):  
Jan Darius Unterlauft ◽  
Wolfram Eichler ◽  
Konstantin Kuhne ◽  
Xiu Mei Yang ◽  
Yousef Yafai ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Glial Cells ◽  
Ganglion Cells ◽  
Pigment Epithelium ◽  
Retinal Ganglion ◽  
Neuroprotective Effects ◽  
Müller Glial Cells ◽  
Pigment Epithelium Derived Factor

scholarly journals Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

Redox Biology ◽  
2019 ◽  
Vol 24 ◽  
pp. 101199 ◽  
Author(s):  
Soumya Navneet ◽  
Jing Zhao ◽  
Jing Wang ◽  
Barbara Mysona ◽  
Shannon Barwick ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Glial Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Müller Glial Cells

scholarly journals Apolipoprotein E Is Synthesized in the Retina by Müller Glial Cells, Secreted into the Vitreous, and Rapidly Transported into the Optic Nerve by Retinal Ganglion Cells

1996 ◽  
Vol 271 (10) ◽  
pp. 5628-5632 ◽  
Author(s):  
Anil Amaratunga ◽  
Carmela R. Abraham ◽  
Ross B. Edwards ◽  
Julie H. Sandell ◽  
Barbara M. Schreiber ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Apolipoprotein E ◽  
Retinal Ganglion Cells ◽  
Glial Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Müller Glial Cells

scholarly journals Pigment epithelium-derived factor protects retinal ganglion cells

2007 ◽  
Vol 8 (1) ◽  
Author(s):  
Iok-Hou Pang ◽  
Hong Zeng ◽  
Debra L Fleenor ◽  
Abbot F Clark
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Pigment Epithelium ◽  
Retinal Ganglion ◽  
Pigment Epithelium Derived Factor

scholarly journals Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons

2020 ◽  
Vol 22 (1) ◽  
pp. 369
Author(s):  
Susanne Bürger ◽  
Jie Meng ◽  
Annette Zwanzig ◽  
Mike Beck ◽  
Maik Pankonin ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Pigment Epithelium ◽  
Laminin Receptor ◽  
Retinal Ganglion ◽  
Retinal Neurons ◽  
Differential Survival ◽  
Hypoxic Conditions ◽  
Pigment Epithelium Derived Factor ◽  
Inhibition Of Angiogenesis

The demise of retinal ganglion cells (RGCs) is characteristic of diseases of the retina such as glaucoma and diabetic or ischemic retinopathies. Pigment epithelium-derived factor (PEDF) is a multifunctional secreted protein that mediates neuroprotection and inhibition of angiogenesis in the retina. We have studied expression and regulation of two of several receptors for PEDF, patatin-like phospholipase 2 gene product/PEDF-R and laminin receptor (LR), in serum-starved RGC under normoxia and hypoxia and investigated their involvement in the survival of retinal neuronal cells. We show that PEDF-R and LR are co-expressed in RGC and R28 retinal precursor cells. Expression of both receptors was enhanced in the presence of complex secretions from retinal glial (Müller) cells and upregulated by VEGF and under hypoxic conditions. PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC. While this study does not provide evidence for a differential survival-promoting influence of either PEDF-R or LR, it nevertheless highlights the importance of both PEDF receptors for the viability of retinal neurons.

Differences in nitric oxide production: a comparison of retinal ganglion cells and retinal glial cells cultured under hypoxic conditions

2003 ◽  
Vol 112 (1-2) ◽  
pp. 126-134 ◽  
Author(s):  
Kenji Kashiwagi ◽  
Yoko Iizuka ◽  
Seiichi Mochizuki ◽  
Yuichi Tsumamoto ◽  
Hiromu K Mishima ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Retinal Ganglion Cells ◽  
Glial Cells ◽  
Ganglion Cells ◽  
Nitric Oxide Production ◽  
Retinal Ganglion ◽  
Oxide Production ◽  
Hypoxic Conditions ◽  
Cells Cultured

Neuroprotective Effects of C-Type Natriuretic Peptide on Rat Retinal Ganglion Cells

2010 ◽  
Vol 51 (7) ◽  
pp. 3544 ◽  
Author(s):  
Jia Ma ◽  
Wenhan Yu ◽  
Yun Wang ◽  
Guiqun Cao ◽  
Suping Cai ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Natriuretic Peptide ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Neuroprotective Effects

Activation of Nrf2 by Ginsenoside Rh3 protects retinal pigment epithelium cells and retinal ganglion cells from UV

2018 ◽  
Vol 117 ◽  
pp. 238-246 ◽  
Author(s):  
Chun-zhou Tang ◽  
Ke-Ran Li ◽  
Qing Yu ◽  
Qin Jiang ◽  
Jin Yao ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Retinal Ganglion ◽  
Retinal Pigment Epithelium Cells ◽  
Epithelium Cells

scholarly journals Neuroprotective effects of exogenous erythropoietin in Wistar rats by downregulating apoptotic factors to attenuate N-methyl-D-aspartate-mediated retinal ganglion cells death

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0223208 ◽  
Author(s):  
Wen-Sheng Cheng ◽  
I-Hung Lin ◽  
Kathy Ming Feng ◽  
Zhi-Yang Chang ◽  
Yu Chuan Huang ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Wistar Rats ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Neuroprotective Effects ◽  
Cells Death ◽  
Apoptotic Factors
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