Glial Cells Activation Potentially Contributes to the Upregulation of Stromal Cell-Derived Factor-1α After Optic Nerve Crush in Rats

2013 ◽  
Vol 38 (10) ◽  
pp. 1996-2008 ◽  
Author(s):  
Xi-Tao Yang ◽  
Dong-Chao Pan ◽  
Er-Tao Chen ◽  
Yong-Yan Bi ◽  
Dong-Fu Feng
Keyword(s):  
Optic Nerve ◽  
Glial Cells ◽  
Stromal Cell ◽  
Optic Nerve Crush ◽  
Nerve Crush ◽  
Stromal Cell Derived Factor

scholarly journals Transcriptome Analyses Reveal Systematic Molecular Pathology After Optic Nerve Crush

2022 ◽  
Vol 15 ◽  
Author(s):  
Yuan-Bo Pan ◽  
Yiyu Sun ◽  
Hong-Jiang Li ◽  
Lai-Yang Zhou ◽  
Jianmin Zhang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Glial Cells ◽  
Optic Nerve Head ◽  
Time Course ◽  
Optic Nerve Crush ◽  
Nerve Crush ◽  
Glial Function ◽  
The Subject ◽  
Transcriptome Analyses ◽  
Insight Into

The function of glial cells in axonal regeneration after injury has been the subject of controversy in recent years. Thus, deeper insight into glial cells is urgently needed. Many studies on glial cells have elucidated the mechanisms of a certain gene or cell type in axon regeneration. However, studies that manipulate a single variable may overlook other changes. Here, we performed a series of comprehensive transcriptome analyses of the optic nerve head over a period of 90 days after optic nerve crush (ONC), showing systematic molecular changes in the optic nerve head (ONH). Furthermore, using weighted gene coexpression network analysis (WGCNA), we established gene module programs corresponding to various pathological events at different times post-ONC and found hub genes that may be potential therapeutic targets. In addition, we analyzed the changes in different glial cells based on their subtype markers. We revealed that the transition trend of different glial cells depended on the time course, which provides clues for modulating glial function in further research.

Different functional susceptibilities of mouse retinal ganglion cell subtypes to optic nerve crush injury

2017 ◽  
Vol 162 ◽  
pp. 97-103 ◽  
Author(s):  
Zhen Puyang ◽  
Hai-Qing Gong ◽  
Shi-Gang He ◽  
John B. Troy ◽  
Xiaorong Liu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Crush Injury ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals Persimmon Leaves (Diospyros kaki) Extract Protects Optic Nerve Crush-Induced Retinal Degeneration

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hong Ryul Ahn ◽  
Kyung-A Kim ◽  
Suk Woo Kang ◽  
Joo Young Lee ◽  
Tae-Jin Kim ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Degeneration ◽  
Diospyros Kaki ◽  
Optic Nerve Crush ◽  
Nerve Crush

scholarly journals Protection by an Oral Disubstituted Hydroxylamine Derivative against Loss of Retinal Ganglion Cell Differentiation following Optic Nerve Crush

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e65966 ◽  
Author(s):  
James D. Lindsey ◽  
Karen X. Duong-Polk ◽  
Yi Dai ◽  
Duy H. Nguyen ◽  
Christopher K. Leung ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Hydroxylamine Derivative

Inhibition of miR-21 ameliorates excessive astrocyte activation and promotes axon regeneration following optic nerve crush

2018 ◽  
Vol 137 ◽  
pp. 33-49 ◽  
Author(s):  
Hong-Jiang Li ◽  
Yuan-Bo Pan ◽  
Zhao-Liang Sun ◽  
Yi-Yu Sun ◽  
Xi-Tao Yang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Axon Regeneration ◽  
Optic Nerve Crush ◽  
Astrocyte Activation ◽  
Nerve Crush

scholarly journals Pim-1 Expression in Rat Retina and its Changes after Optic Nerve Crush

2018 ◽  
Vol 301 (11) ◽  
pp. 1968-1976
Author(s):  
Shoumei Zhang ◽  
Dong Wang ◽  
Tingting Huang ◽  
Fang Liu ◽  
Li Shuai ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Nerve Crush ◽  
Rat Retina
Sign in / Sign up

Export Citation Format

Share Document