Diphenyl Diselenide Prevents Cortico-cerebral Mitochondrial Dysfunction and Oxidative Stress Induced by Hypercholesterolemia in LDL Receptor Knockout Mice

2013 ◽  
Vol 38 (10) ◽  
pp. 2028-2036 ◽  
Author(s):  
Jade de Oliveira ◽  
Eduardo Luiz Gasnhar Moreira ◽  
Gianni Mancini ◽  
Mariana Appel Hort ◽  
Alexandra Latini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Knockout Mice ◽  
Ldl Receptor ◽  
Diphenyl Diselenide ◽  
Ldl Receptor Knockout Mice ◽  
And Oxidative Stress

Baroreflex sensitivity and oxidative stress in the LDL receptor knockout mice

2008 ◽  
Vol 60 (4-5) ◽  
pp. 329-335 ◽  
Author(s):  
Cristina Campos ◽  
Mariane Bertagnolli ◽  
Juliano Evangelho ◽  
Cintia Tusset ◽  
Adriane Belló-Klein ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Knockout Mice ◽  
Baroreflex Sensitivity ◽  
Ldl Receptor ◽  
Ldl Receptor Knockout Mice ◽  
And Oxidative Stress

scholarly journals S12.36 Oxidative stress in hypercholesterolemic ldl receptor knockout mice: Role of mitochondrial nadp-linked substrates and intracellular calcium levels

2008 ◽  
Vol 1777 ◽  
pp. S84
Author(s):  
Bruno A. Paim ◽  
Jesus A. Velho ◽  
Giovanna R. Degasperi ◽  
Roger F. Castilho ◽  
Helena C.F. Oliveira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intracellular Calcium ◽  
Knockout Mice ◽  
Ldl Receptor ◽  
Ldl Receptor Knockout Mice

OXIDATIVE STRESS IN LDL RECEPTOR KNOCKOUT MICE IS ASSOCIATED WITH LOW CONTENT OF MITOCHONDRIAL NADP-LINKED SUBSTRATES

2008 ◽  
Vol 9 (1) ◽  
pp. 43
Author(s):  
B.A. Paim ◽  
J.A. Velho ◽  
R.F. Castilho ◽  
H.C. Oliveira ◽  
A.E. Vercesi
Keyword(s):  
Oxidative Stress ◽  
Knockout Mice ◽  
Ldl Receptor ◽  
Ldl Receptor Knockout Mice

scholarly journals Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0239625
Author(s):  
Prasanna M. Chandramouleeswaran ◽  
Manti Guha ◽  
Masataka Shimonosono ◽  
Kelly A. Whelan ◽  
Hisatsugu Maekawa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
And Oxidative Stress

scholarly journals One Week of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver

2021 ◽  
Vol 22 (11) ◽  
pp. 5851
Author(s):  
Takehito Sugasawa ◽  
Seiko Ono ◽  
Masato Yonamine ◽  
Shin-ichiro Fujita ◽  
Yuki Matsumoto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
High Fat Diet ◽  
Early Stage ◽  
Droplet Deposition ◽  
Nonalcoholic Fatty Liver ◽  
Stress Markers ◽  
Mitochondrial Dna Copy Number ◽  
Short Period ◽  
And Oxidative Stress

The prevalence of nonalcoholic fatty liver disease (NAFLD) has been rapidly increasing worldwide. A choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) has been used to create a mouse model of nonalcoholic steatohepatitis (NASH). There are some reports on the effects on mice of being fed a CDAHFD for long periods of 1 to 3 months. However, the effect of this diet over a short period is unknown. Therefore, we examined the effect of 1-week CDAHFD feeding on the mouse liver. Feeding a CDAHFD diet for only 1-week induced lipid droplet deposition in the liver with increasing activity of liver-derived enzymes in the plasma. On the other hand, it did not induce fibrosis or cirrhosis. Additionally, it was demonstrated that CDAHFD significantly impaired mitochondrial respiration with severe oxidative stress to the liver, which is associated with a decreasing mitochondrial DNA copy number and complex proteins. In the gene expression analysis of the liver, inflammatory and oxidative stress markers were significantly increased by CDAHFD. These results demonstrated that 1 week of feeding CDAHFD to mice induces steatohepatitis with mitochondrial dysfunction and severe oxidative stress, without fibrosis, which can partially mimic the early stage of NASH in humans.

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