Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau

2005 ◽  
Vol 34 (6) ◽  
pp. 397-410 ◽  
Author(s):  
Wen-Lang Lin ◽  
Cindy Zehr ◽  
Jada Lewis ◽  
Michael Hutton ◽  
Shu-Hui Yen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Transgenic Mice ◽  
White Matter Pathology

scholarly journals Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injury

2007 ◽  
Vol 58 (2) ◽  
pp. 253-260 ◽  
Author(s):  
Joong Hee Kim ◽  
David N. Loy ◽  
Hsiao-Fang Liang ◽  
Kathryn Trinkaus ◽  
Robert E. Schmidt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Mouse Model ◽  
Diffusion Tensor ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
White Matter Pathology

A characterization of white matter pathology following spinal cord compression injury in the rat

Neuroscience ◽  
2014 ◽  
Vol 260 ◽  
pp. 227-239 ◽  
Author(s):  
R.E. Ward ◽  
W. Huang ◽  
M. Kostusiak ◽  
P.N. Pallier ◽  
A.T. Michael-Titus ◽  
...  
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Compression Injury ◽  
White Matter Pathology

Imaging White Matter Pathology in Epilepsy

2019 ◽  
pp. 68-76
Author(s):  
Min Liu ◽  
Luis Concha ◽  
Boris C. Bernhardt ◽  
Neda Bernasconi ◽  
Andrea Bernasconi
Keyword(s):  
White Matter ◽  
White Matter Pathology

Contusion, dislocation, and distraction: primary hemorrhage and membrane permeability in distinct mechanisms of spinal cord injury

2007 ◽  
Vol 6 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Anthony M. Choo ◽  
Jie Liu ◽  
Clarrie K. Lam ◽  
Marcel Dvorak ◽  
Wolfram Tetzlaff ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
White Matter ◽  
Animal Models ◽  
Membrane Permeability ◽  
High Speed ◽  
Test System ◽  
Fracture Dislocation ◽  
Sprague Dawley ◽  
Cord Injury

Object In experimental models of spinal cord injury (SCI) researchers have typically focused on contusion and transection injuries. Clinically, however, other injury mechanisms such as fracture–dislocation and distraction also frequently occur. The objective of the present study was to compare the primary damage in three clinically relevant animal models of SCI. Methods Contusion, fracture–dislocation, and flexion–distraction animal models of SCI were developed. To visualize traumatic increases in cellular membrane permeability, fluorescein–dextran was infused into the cerebrospi-nal fluid prior to injury. High-speed injuries (approaching 100 cm/second) were produced in the cervical spine of deeply anesthetized Sprague–Dawley rats (28 SCI and eight sham treated) with a novel multimechanism SCI test system. The animals were killed immediately thereafter so that the authors could characterize the primary injury in the gray and white matter. Sections stained with H & E showed that contusion and dislocation injuries resulted in similar central damage to the gray matter vasculature whereas no overt hemorrhage was detected following distraction. Contusion resulted in membrane disruption of neuronal somata and axons localized within 1 mm of the lesion epicenter. In contrast, membrane compromise in the dislocation and distraction models was observed to extend rostrally up to 5 mm, particularly in the ventral and lateral white matter tracts. Conclusions Given the pivotal nature of hemorrhagic necrosis and plasma membrane compromise in the initiation of downstream SCI pathomechanisms, the aforementioned differences suggest the presence of mechanism-specific injury regions, which may alter future clinical treatment paradigms.

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