Intravenous Hydrophobic Drug Delivery: A Porous Particle Formulation of Paclitaxel (AI-850)

2005 ◽  
Vol 22 (3) ◽  
pp. 347-355 ◽  
Author(s):  
Julie A. Straub ◽  
Donald E. Chickering ◽  
Jonathan C. Lovely ◽  
Huimin Zhang ◽  
Bhavdeep Shah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Particle ◽  
Hydrophobic Drug

Magnetic Nanoparticles Grafted with Cyclodextrin for Hydrophobic Drug Delivery

2007 ◽  
Vol 19 (25) ◽  
pp. 6345-6349 ◽  
Author(s):  
Shashwat S. Banerjee ◽  
Dong-Hwang Chen
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Hydrophobic Drug

Nanoparticulate Drug Delivery Systems: An update

2021 ◽  
pp. 312-316
Author(s):  
Pandey Swarnima ◽  
Sushant Kumar
Keyword(s):  
Drug Delivery ◽  
Carrying Capacity ◽  
Drug Delivery Systems ◽  
High Specificity ◽  
Delivery Systems ◽  
Classification Methods ◽  
Hydrophobic Drug ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Novel Drug

The paper is aimed to provide a comprehensive review on nanoparticles, methods of preparation, applications in drug delivery. In recent years, there has been an exponential interest within the development of novel drug delivery systems using nanoparticles. Nanoparticles offers significant advantages over the conventional drug delivery in terms of high stability, high specificity, high drug carrying capacity, ability for controlled release, possibility to use in several route of administration and therefore the capability to deliver both hydrophilic and hydrophobic drug molecules. This review focuses on classification, methods of preparation, characterization, application, advantages of nanoparticles and health perspectives.

scholarly journals A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 97 ◽  
Author(s):  
Delia Mandracchia ◽  
Adriana Trapani ◽  
Sara Perteghella ◽  
Cinzia Di Franco ◽  
Maria Torre ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Beclomethasone Dipropionate ◽  
Polymeric Micelles ◽  
Hydrophobic Drugs ◽  
Hydrophobic Drug ◽  
Hydrophilic Drugs ◽  
Uv Crosslinking ◽  
Colon Drug Delivery ◽  
Materials Used ◽  
Simultaneous Delivery

Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination therapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking of a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically degraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles were physicochemically characterized and subjected to UV irradiation to form what we called the “nanogrids”. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and beclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug was specifically assessed to verify that it can spread along the hydrophilic portions and, therefore, effectively released. These systems can open new pharmaceutical applications for known hydrogels or micelle systems, considering that in literature only few examples are present.

A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel

2008 ◽  
Vol 359 (1-2) ◽  
pp. 228-233 ◽  
Author(s):  
MaLing Gou ◽  
XingYi Li ◽  
Mei Dai ◽  
ChangYang Gong ◽  
XianHuo Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Biodegradable Nanoparticles

Schiff-base based hydrogels as degradable platforms for hydrophobic drug delivery

2017 ◽  
Vol 90 ◽  
pp. 13-24 ◽  
Author(s):  
Esmat Jalalvandi ◽  
Lyall R. Hanton ◽  
Stephen C. Moratti
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Hydrophobic Drug

scholarly journals Synthesis and characterization of perfluoro-tert-butyl semifluorinated amphiphilic polymers and their potential application in hydrophobic drug delivery

2014 ◽  
Vol 5 (22) ◽  
pp. 6461-6471 ◽  
Author(s):  
Sarah Decato ◽  
Troy Bemis ◽  
Eric Madsen ◽  
Sandro Mecozzi
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Amphiphilic Polymers ◽  
Synthesis And Characterization ◽  
Hydrophobic Drug ◽  
Tert Butyl ◽  
Theranostic Applications ◽  
Polymer Surfactants

Semifluorinated polymer surfactants containing one, two, or three perfluoro-tert-butyl groups were synthesized and fully characterized. Theranostic applications are discussed.

In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers

2018 ◽  
Vol 47 ◽  
pp. 62-66 ◽  
Author(s):  
Yuko Okamoto ◽  
Kazuaki Taguchi ◽  
Mina Sakuragi ◽  
Shuhei Imoto ◽  
Keishi Yamasaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Hydrophobic Drug ◽  
Delivery Efficiency

An Overview of Nanoparticles: Current Scenario

2021 ◽  
pp. 239-246
Author(s):  
Seema U. Shinde ◽  
Nikita D. Gidde ◽  
Pradnya P. Shinde ◽  
Akshay B. Kadam
Keyword(s):  
Drug Delivery ◽  
High Stability ◽  
Hydrophobic Drug ◽  
Preparation Methods ◽  
Routes Of Administration ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Current Scenario ◽  
Release Potential ◽  
Novel Drug

The simplest type of structures with sizes in the nm range will be nanoparticles. Any atom mean that is associated by intensity with other atoms within a 'limited' distance may be claimed to be a nanoparticle in principle. The creation of novel drug delivery systems using nanoparticles has seen an exponential interest in recent years. In terms of high stability, high precision, high drug carrying capability, managed release potential, the possibility of use in various routes of administration and the ability to deliver both hydrophilic and hydrophobic drug molecules, nanoparticles may offer significant advantages over conventional drug delivery. The emphasis of this study is on classification, types, synthesis, preparation methods, characterization, use, nanoparticle advantages, and health perspectives.

Drug Delivery: Vaults Engineered for Hydrophobic Drug Delivery (Small 10/2011)

Small ◽  
2011 ◽  
Vol 7 (10) ◽  
pp. 1431-1431
Author(s):  
Daniel C. Buehler ◽  
Daniel B. Toso ◽  
Valerie A. Kickhoefer ◽  
Z. Hong Zhou ◽  
Leonard H. Rome
Keyword(s):  
Drug Delivery ◽  
Hydrophobic Drug

Formation of Controllable Hydrophilic/Hydrophobic Drug Delivery Systems by Electrospinning of Vesicles

Langmuir ◽  
2015 ◽  
Vol 31 (18) ◽  
pp. 5141-5146 ◽  
Author(s):  
Wei Li ◽  
Tian Luo ◽  
Yanjuan Yang ◽  
Xiuniang Tan ◽  
Lifei Liu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hydrophobic Drug
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