Nanoparticulate Drug Delivery Systems: An update

2021 ◽  
pp. 312-316
Author(s):  
Pandey Swarnima ◽  
Sushant Kumar
Keyword(s):  
Drug Delivery ◽  
Carrying Capacity ◽  
Drug Delivery Systems ◽  
High Specificity ◽  
Delivery Systems ◽  
Classification Methods ◽  
Hydrophobic Drug ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Novel Drug

The paper is aimed to provide a comprehensive review on nanoparticles, methods of preparation, applications in drug delivery. In recent years, there has been an exponential interest within the development of novel drug delivery systems using nanoparticles. Nanoparticles offers significant advantages over the conventional drug delivery in terms of high stability, high specificity, high drug carrying capacity, ability for controlled release, possibility to use in several route of administration and therefore the capability to deliver both hydrophilic and hydrophobic drug molecules. This review focuses on classification, methods of preparation, characterization, application, advantages of nanoparticles and health perspectives.

An Overview of Nanoparticles: Current Scenario

2021 ◽  
pp. 239-246
Author(s):  
Seema U. Shinde ◽  
Nikita D. Gidde ◽  
Pradnya P. Shinde ◽  
Akshay B. Kadam
Keyword(s):  
Drug Delivery ◽  
High Stability ◽  
Hydrophobic Drug ◽  
Preparation Methods ◽  
Routes Of Administration ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Current Scenario ◽  
Release Potential ◽  
Novel Drug

The simplest type of structures with sizes in the nm range will be nanoparticles. Any atom mean that is associated by intensity with other atoms within a 'limited' distance may be claimed to be a nanoparticle in principle. The creation of novel drug delivery systems using nanoparticles has seen an exponential interest in recent years. In terms of high stability, high precision, high drug carrying capability, managed release potential, the possibility of use in various routes of administration and the ability to deliver both hydrophilic and hydrophobic drug molecules, nanoparticles may offer significant advantages over conventional drug delivery. The emphasis of this study is on classification, types, synthesis, preparation methods, characterization, use, nanoparticle advantages, and health perspectives.

Novel Drug Delivery System of Phytopharmaceuticals: A Review

2021 ◽  
Vol 07 ◽  
Author(s):  
Sumit Aroraa ◽  
Veerendra Dhoke ◽  
Keshav Moharir ◽  
Subhash Yende ◽  
Sapan Shah
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Distribution ◽  
Delivery Systems ◽  
Research Activity ◽  
Innovative Drug ◽  
Preparation Methods ◽  
Conventional Drug ◽  
Sites Of Action ◽  
Novel Drug

: Herbal extracts and isolated bioactives from plants have proven their therapeutic activities as evidenced by preclinical and clinical research. However, there seems some disconnect in their clinical utility as marked by lack of proper delivery mechanism at desired sites of action. This glitch nowadays is a task for global research activity and being addressed in the form of novel drug delivery systems. A steady progress is observed in integrating novel techniques of drug delivery with successful incorporation of phytochemicals marked by scores of advantages. Limitations of conventional drug delivery systems are overcome to considerable extent by innovative drug delivery methods which show improvement in targeted drug delivery, drug distribution, and protection of active substance, prolonged action and stability. The perspective of this review thus focuses on the progress in novel drug delivery systems with spotlight on nanocarriers for herbal active agents, their preparation methods with types, examples of active ingredients incorporated and biomedical applications.

scholarly journals Novel Drug Delivery Systems for Rheumatoid Arthritis: An Approach to Better Patient Compliance

2019 ◽  
Vol 12 (1) ◽  
pp. 157-170 ◽  
Author(s):  
Sangeeta Mohanty ◽  
Sthitapragnya Panda ◽  
Aslesha Bhanja ◽  
Abhisek Pal ◽  
Si Sudam Chandra
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Human Life ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Future Perspectives ◽  
Conventional Drug ◽  
Potential Applications ◽  
Novel Drug

Recent advances in science and technology radically changed the way we detect, treat and prevent different diseases in all aspects of human life. Rheumatoid arthritis (RA) is a chronic, systemic, progressive, autoimmune disease in which the body’s immune system whose major role is to protect the health by attacking foreign bacteria and viruses are mistakenly, attacking the joints resulting in thickened synovium, pannus formation, & destruction of bone, cartilage. Still now researchers are unable to know the exact cause of this disease. However, it is believed that genes and environmental factors play a role in development of RA. In this review, we discuss the Pathophysiology, predictors, & factors involved in pathogenesis of RA. We also discuss the Conventional therapeutic agents for Rheumatoid Arthritis. More importantly, we extensively discuss the emerging novel drug delivery systems (NDDS) like nanoparticles, dendrimers, micelles, microspheres, liposomes, and so on as these are the promising tools having successful applications in overcoming the limitations associated with conventional drug delivery systems. Although several NDDS have been used for various purposes, liposomes have been focused on due to its potential applications in RA diagnosis and therapy. In addition, we discuss the therapeutic effectiveness and challenges for RA by using these novel drug delivery systems. Finally, we conclude by discussing the future perspectives.

Nanotechnology: Revolutionizing the Science of Drug Delivery

2019 ◽  
Vol 24 (43) ◽  
pp. 5086-5107 ◽  
Author(s):  
Mohini Mishra ◽  
Pramod Kumar ◽  
Jitendra Singh Rajawat ◽  
Ruchi Malik ◽  
Gitanjali Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Structural Features ◽  
Delivery Systems ◽  
The Novel ◽  
Drug Delivery Vehicles ◽  
Conventional Drug ◽  
Diagnostic Agents ◽  
Pros And Cons ◽  
Novel Drug

Growing interest in the field of nanotechnology has led to its emergence in the field of medicine too. Nanomedicines encompass the various medical tools, diagnostic agents and the drug delivery vehicles being evolved with the advancements in the aura of nanotechnology. This review emphasizes on providing a cursory literature on the past events that led to the procession of nanomedicines, various novel drug delivery systems describing their structural features along with the pros and cons associated with them and the nanodrugs that made a move to the clinical practice. It also focuses on the need of the novel drug delivery systems and the challenges faced by the conventional drug delivery systems.

scholarly journals A comprehensive review on polymeric micelles: a promising drug delivery carrier

2021 ◽  
Vol 10 (3) ◽  
pp. 102-107
Author(s):  
Ajay Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Hydrophobic Drug ◽  
Drug Release Profile ◽  
Physiological Conditions ◽  
Drug Molecules ◽  
Drug Delivery Carrier

The main aim of drug delivery systems is to regulate the rate of drug release as per the patient's physiological conditions as well as the progression of the illness or as per the circadian rhythms. To achieve such objectives, the new drug delivery systems have been developed to provide the drug release profile, which is based on each patient's needs. Different researches have been done to create drug delivery carriers, focusing on targeting and delivering hydrophobic drug molecules. This review focuses on Polymeric Micelles as the promising drug delivery carrier due to its high stability, protective property against the harsh gastrointestinal environment.

scholarly journals TRANSFEROSOME: A RECENT APPROACH FOR TRANSDERMAL DRUG DELIVERY

2018 ◽  
Vol 8 (5-s) ◽  
pp. 100-104 ◽  
Author(s):  
Abhay Kumar
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ionic Surfactant ◽  
Drug Molecules ◽  
Wide Range ◽  
Targeted Drug ◽  
Novel Drug

Novel drug delivery systems are now a day is creating a new interest in development of drug deliveries. The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. Transferosomes are capable of transdermal delivery of low as well as high molecular weight drugs. This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin, by the use of penetration enhancers and non-ionic surfactant vesicles. It is suitable for controlled and targeted drug delivery and it can accommodate drug molecules with wide range of solubility. Due to its high deformability it gives better penetration of intact vesicles. Transferosome possess an infrastructure consisting of hydrophobic and hydrophilic moieties together and as a result can accommodate drug molecules with wide range of solubility. They are biocompatible and biodegradable as they are made from natural phospholipids and have high entrapment efficiency. In this review, we have focused on transferosome with discussions on novel drug delivery systems for targeted delivery of therapeutics and important issues and challenges for future clinical applications. Keywords: Novel drug delivery systems, Transferosomes, Transdermal drug delivery, Targeted drug delivery

scholarly journals CRYPTOSOMES: A REVOLUTIONARY BREAKTHROUGH IN NOVEL DRUG DELIVERY

2019 ◽  
Vol 11 (1) ◽  
pp. 7 ◽  
Author(s):  
Aiswarya M. U. ◽  
Keerthana Raju ◽  
Revathy B. Menon ◽  
Lakshmi V. S. ◽  
Sreeja C. Nair
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Phosphatidyl Ethanolamine ◽  
Delivery Systems ◽  
The Body ◽  
Solid Lipid ◽  
Conventional Drug ◽  
Novel Drug

The vesicular drug delivery systems are promising approaches to overthrown the problems of drugs having lesser bioavailability and rapid elimination from the body. The four type of lipid based drug delivery systems are: solid-lipid particulate system, emulsion based system, solid lipid tablet and vesicular system. Cryptosomes, a novel emerging vesicular drug delivery system which can overcome the disadvantages associated with conventional drug delivery systems like high stability, increased bioavailability, sustained release, decreased elimination of rapidly metabolizable drugs etc. The word Cryptosome was orginated from Greek word ‘’Crypto’’ means hidden and ‘’Soma’’ means body. It is formed from the mixture of phospholipids like distearoyl phosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG) with distearoylphosphatidylcholine. These entire information regarding its origin and formation is explained in Dinesh Kumar et al. Vesicular systems symbolizes the use of vesicles in the different fields as carrier system or additives. This review disclose various vesicular drug delivery system and point out the advancement of cryptosome in the world of drug delivery.This review would help researchers involved in the field of vesicular drug delivery.

scholarly journals Graphene Oxide as a Nanocarrier for Biochemical Molecules: Current Understanding and Trends

Processes ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 1636
Author(s):  
Soumajit Mukherjee ◽  
Zuzana Bytesnikova ◽  
Amir M. Ashrafi ◽  
Vojtech Adam ◽  
Lukas Richtera
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
High Specificity ◽  
Delivery Systems ◽  
Current Understanding ◽  
Design And Synthesis ◽  
Drug Molecules ◽  
Therapeutic Value ◽  
Low Cytotoxicity ◽  
Novel Drug

The development of an advanced and efficient drug delivery system with significant improvement in its efficacy and enhanced therapeutic value is one of the critical challenges in modern medicinal biology. The integration of nanomaterial science with molecular and cellular biology has helped in the advancement and development of novel drug delivery nanocarrier systems with precision and decreased side effects. The design and synthesis of nanocarriers using graphene oxide (GO) have been rapidly growing over the past few years. Due to its remarkable physicochemical properties, GO has been extensively used in efforts to construct nanocarriers with high specificity, selectivity, and biocompatibility, and low cytotoxicity. The focus of this review is to summarize and address recent uses of GO-based nanocarriers and the improvements as efficient drug delivery systems. We briefly describe the concepts and challenges associated with nanocarrier systems followed by providing critical examples of GO-based delivery of drug molecules and genes. Finally, the review delivers brief conclusions on the current understanding and prospects of nanocarrier delivery systems.

scholarly journals Novel Drug Delivery Systems and its Future Prospects

2022 ◽  
Vol 24 (1) ◽  
pp. 48-60
Author(s):  
Avani K. Shewale ◽  
◽  
Akshay R. Yadav ◽  
Ashwini S. Jadhav ◽  
◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Drug Level ◽  
Delivery Systems ◽  
The Body ◽  
Conventional Drug ◽  
Novel Drug Delivery System ◽  
Novel Drug

Most common methods of delivery include the preferred topical (skin), transmucosal (nasal, buccal, sublingual, vaginal, ocular and rectal) and inhalation routes. The conventional dosage forms provide drug release immediately and it causes fluctuation of drug level in blood depending upon dosage form. Therefore to maintain the drug concentration within therapeutically effective range needs novel drug delivery system. In the past few decades, considerable attention has been focused on the development of novel drug delivery system (NDDS). The NDDS should ideally fulfill two prerequisites. Firstly, it should deliver the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it should channel the active entity to the site of action. In conventional drug delivery systems, there is little or no control over release of the drug and effective concentration at the target site can be achieved by irregular administration of grossly excessive doses. At present, no available drug delivery system behaves ideally, but sincere attempts have been made to achieve them through various novel approaches in drug delivery.

Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis

2020 ◽  
Vol 26 ◽  
Author(s):  
Ritu Mishra ◽  
Swati Gupta
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Autoimmune Disease ◽  
Drug Delivery Systems ◽  
Clinical Manifestations ◽  
Adaptive Immune Response ◽  
Delivery Systems ◽  
Current Therapy ◽  
Genetic And Environmental Factors ◽  
Novel Drug

Background: Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome by the use of novel drug delivery systems. : The objective of the present review is to focus on the molecular pathogenesis of the disease and its current conventional treatment with special reference to the role of novel drug delivery systems encapsulating anti rheumatic drugs and herbal drugs in passive and receptor mediated active targeting against RA. On reviewing the conventional and current therapeutics agains RA, we conclude that, although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.

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