The impact of progressive chronic kidney disease on health-related quality-of-life: a 12-year community cohort study

2019 ◽  
Vol 28 (8) ◽  
pp. 2081-2090 ◽  
Author(s):  
Melanie L. R. Wyld ◽  
Rachael L. Morton ◽  
Phil Clayton ◽  
Muh Geot Wong ◽  
Meg Jardine ◽  
...  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tae Ryom Oh ◽  
Hong Sang Choi ◽  
Chang Seong Kim ◽  
Eun Hui Bae ◽  
Yun Kyu Oh ◽  
...  

AbstractThe impact of health-related quality of life (HRQOL) on outcomes remains unclear in chronic kidney disease (CKD) patients despite its importance in socioeconomic aspects and individual health. We aim to identify the relationship between HRQOL and progression of CKD in pre-dialysis patients. A total 1622 patients with CKD were analyzed in the KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease, a prospective cohort study. CKD progression was defined as one or more of the following: initiation of dialysis or transplantation, a two-fold increase in baseline serum creatinine levels, or a 50% decline in the estimated glomerular filtration rate during the follow-up period. The group with CKD progression had lower scores of HRQOL than the group without CKD progression. A fully adjusted Cox proportional hazard ratio model showed that each low baseline physical and mental component summary score was associated with a higher risk of CKD progression. In Kaplan-Meier survival analysis using propensity score matched data, only low physical component summary scores showed statistical significance with CKD progression. Our study highlights low physical component summary score for an important prognostic factor of CKD progression. Risk-modification interventions for high-risk patients may provide benefits to individuals.


2013 ◽  
Vol 163 (3) ◽  
pp. 736-741.e1 ◽  
Author(s):  
Amira Al-Uzri ◽  
Matthew Matheson ◽  
Debbie S. Gipson ◽  
Susan R. Mendley ◽  
Stephen R. Hooper ◽  
...  

2009 ◽  
Vol 169 (12) ◽  
pp. 1104 ◽  
Author(s):  
Fiona M. Clement ◽  
Scott Klarenbach ◽  
Marcello Tonelli ◽  
Jeffrey A. Johnson ◽  
Braden J. Manns

2021 ◽  
Vol 6 (4) ◽  
pp. S146
Author(s):  
P. MCEWAN ◽  
O. Darlington ◽  
J. Garcia-Sanchez ◽  
N. Rao ◽  
D. Wheeler ◽  
...  

RAHIS ◽  
2021 ◽  
Vol 18 (2) ◽  
pp. 20-40
Author(s):  
Pablo Aurélio Lacerda de Almeida Pinto ◽  
Laisse Nogueira de Sá Sá ◽  
Bruno Nunes Guedes ◽  
Fagner José Coutinho de Melo

Objective: This study aims to assess the health-related quality of life (HRQoL) of patients with chronic kidney disease (CKD) at a charity in Salgueiro, Brazil, in order to support the design of public policies that improve the quality of life. life. Method: Methodologically, it is a descriptive quantitative study, with a prospective transversal cohort approach. The instrument used was the Health Utilities Index (HUI), in which patients on hemodialysis self-evaluated and had their health status assessed by the responsible physicians. Theoretical basis: There are few studies evaluating the impact of medical treatment on the HRQoL of patients in Brazil, mainly in relation to CKD. In this way, this study was based on several works that approach the subject, such as Romão Junior (2004), Furlong et al. (2001), Rodrigues (2011), Del Nero (2002), Sesso et al. (2016), Carvalho (2012) and Melo et al. (2000). Results: The results showed that the majority of patients and doctors considered that the treatment impaired health-related quality of life. Conclusions/contributions: The results of the research suggest that managers of basic public health policies can launch measures that aim to make the community aware of the problems that most cause CKD, such as hypertension and diabetes.


2019 ◽  
Author(s):  
Austyn Snowden ◽  
Jenny Young ◽  
Jan Savinc

Abstract Background Cancer impacts on patients and their families across a range of different domains. For that reason, optimal cancer care has moved away from a disease-centric focus to a more holistic approach in order to proactively support people with their individual needs and concerns. While international policy clearly advocates this agenda, implementation into routine care is limited. Therefore, relevant interventions that measurably improve patient outcomes are essential to understand if this ideal is to become routine multidisciplinary practice. The aim of this study was to analyse the impact of a proactive, holistic, community-based intervention on health-related quality of life in a cohort of people diagnosed with cancer. Secondary aim was to explore the relationship between changes in health status and: cancer type, cancer stage, number of concerns expressed and change in severity of concerns pre and post intervention. Method Prospective observational cohort study. A convenience sample of 437 individuals were referred to the service ‘Improving the Cancer Journey (ICJ) in the UK. Each completed the Euroqol EQ-5D-3L and visual analogue scale (VAS) and a Holistic Needs Assessment (HNA) during initial visit to the service and again at follow-up review, approximately 4 months later. Change between scores was tested with paired t-tests and relationships between variables with multiple regression models. Results Participants were White British with median age between 50-64 years. Cancer type and stage were varied. There was a statistically significant improvement in EQ-5D scores over time (t(330)=7.48, p<.001). The strongest predictor of change was a decrease in severity of concerns. Cancer stage ‘palliative care’ contributed to a reduction in health status. Conclusion This study is the first to show that a holistic community intervention dedicated to supporting the individual concerns of participants has a statistically and meaningful impact on participants’ health-related quality of life. The mean change in EQ-5D scores was more than the ‘minimally important clinical difference’ described in the literature. This is important because while quality of life has multiple determinants this study has reported that it is possible to capture a meaningful improvement as a function of reducing someone’s personally identified concerns.


PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0257981
Author(s):  
Jung-Hwa Ryu ◽  
Tai Yeon Koo ◽  
Han Ro ◽  
Jang-Hee Cho ◽  
Myung-Gyu Kim ◽  
...  

Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1–3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. Furthermore, KT was an independent prognostic factor for better HRQOL. These results highlight that KT can offer a better HRQOL than that of CKD patients, even when renal function is similar.


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