Identification and characterization of an E3 ubiquitin ligase Rbx1 in maize (Zea mays L.)

2013 ◽  
Vol 116 (2) ◽  
pp. 253-260 ◽  
Author(s):  
Liuji Wu ◽  
Xiuli Hu ◽  
Xiao Chen ◽  
Liancheng Wu ◽  
Yanhui Chen
Keyword(s):  
Zea Mays ◽  
Ubiquitin Ligase ◽  
Zea Mays L ◽  
E3 Ubiquitin Ligase ◽  
Identification And Characterization

Identification and characterization of two members of the FtsH gene family in maize (Zea mays L.)

2009 ◽  
Vol 37 (2) ◽  
pp. 855-863 ◽  
Author(s):  
Guidong Yue ◽  
Xiaorui Hu ◽  
Ying He ◽  
Aifang Yang ◽  
Juren Zhang
Keyword(s):  
Zea Mays ◽  
Gene Family ◽  
Zea Mays L ◽  
Identification And Characterization

scholarly journals Identification and characterization of endophytic bacteria from corn (Zea mays L.) roots with biotechnological potential in agriculture

AMB Express ◽  
2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Vivian Jaskiw Szilagyi-Zecchin ◽  
Angela Cristina Ikeda ◽  
Mariangela Hungria ◽  
Douglas Adamoski ◽  
Vanessa Kava-Cordeiro ◽  
...  
Keyword(s):  
Zea Mays ◽  
Endophytic Bacteria ◽  
Zea Mays L ◽  
Biotechnological Potential ◽  
Identification And Characterization

Identification and characterization of MOR-CP, a cysteine protease induced by ozone and developmental senescence in maize (Zea mays L.) leaves

Chemosphere ◽  
2014 ◽  
Vol 108 ◽  
pp. 245-250 ◽  
Author(s):  
Rafiq Ahmad ◽  
Yasmine Zuily-Fodil ◽  
Chantal Passaquet ◽  
Olivier Bethenod ◽  
Romain Roche ◽  
...  
Keyword(s):  
Zea Mays ◽  
Cysteine Protease ◽  
Zea Mays L ◽  
Identification And Characterization

scholarly journals Genome-Wide Identification and Characterization of microRNAs in Developing Grains of Zea mays L.

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153168 ◽  
Author(s):  
Dandan Li ◽  
Zongcai Liu ◽  
Lei Gao ◽  
Lifang Wang ◽  
Meijuan Gao ◽  
...  
Keyword(s):  
Zea Mays ◽  
Zea Mays L ◽  
Genome Wide ◽  
Identification And Characterization ◽  
Developing Grains

Sequence, identification and characterization of cDNAs encoding two different members of the 18 kDa heat shock family of Zea mays L.

1991 ◽  
Vol 16 (4) ◽  
pp. 699-711 ◽  
Author(s):  
Ing Swie Goping ◽  
J. Roger H. Frappier ◽  
David B. Walden ◽  
Burr G. Atkinson
Keyword(s):  
Zea Mays ◽  
Heat Shock ◽  
Zea Mays L ◽  
Sequence Identification ◽  
Identification And Characterization

scholarly journals RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation

Blood ◽  
2021 ◽  
Author(s):  
Li Jiang ◽  
Jiaming Wang ◽  
Kai Wang ◽  
Hao Wang ◽  
Qian Wu ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Iron Homeostasis ◽  
Iron Absorption ◽  
E3 Ubiquitin Ligase ◽  
Conditional Knockout ◽  
Conditional Knockout Mouse ◽  
Ubiquitin Ligase Activity ◽  
Subsequent Degradation ◽  
Identification And Characterization

Ferroportin (FPN), the body's sole iron exporter, is essential for maintaining systemic iron homeostasis. In response to either increased iron or inflammation, hepatocyte-secreted hepcidin binds to FPN, inducing its internalization and subsequent degradation. However, the E3 ubiquitin ligase that underlies FPN degradation has not been identified. Here, we report the identification and characterization of a novel mechanism involving the RNF217-mediated degradation of FPN. A combination of two different E3 screens revealed that the Rnf217 gene is a target of Tet1, mediating the ubiquitination and subsequent degradation of FPN. Interestingly, loss of Tet1 expression causes an accumulation of FPN and an impaired response to iron overload, manifested by increased iron accumulation in the liver together with decreased iron in the spleen and duodenum. Moreover, we found that the degradation and ubiquitination of FPN could be attenuated by mutating RNF217. Finally, using two conditional knockout mouse lines, we found that knocking out Rnf217 in macrophages increases splenic iron export by stabilizing FPN, whereas knocking out Rnf217 in intestinal cells appears to increase iron absorption. These findings suggest that the Tet1-RNF217-FPN axis regulates iron homeostasis, revealing new therapeutic targets for FPN-related diseases.

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