MtTdp2α-overexpression boosts the growth phase of Medicago truncatula cell suspension and increases the expression of key genes involved in the antioxidant response and genome stability

2016 ◽  
Vol 127 (3) ◽  
pp. 675-680 ◽  
Author(s):  
Susana Araújo ◽  
Alma Balestrazzi ◽  
Matteo Faè ◽  
Martina Morano ◽  
Daniela Carbonera ◽  
...  
Keyword(s):  
Cell Suspension ◽  
Medicago Truncatula ◽  
Growth Phase ◽  
Genome Stability ◽  
Antioxidant Response ◽  
Key Genes

scholarly journals Methyl jasmonate and yeast elicitor induce differential transcriptional and metabolic re-programming in cell suspension cultures of the model legume Medicago truncatula

Planta ◽  
2004 ◽  
Vol 220 (5) ◽  
pp. 696-707 ◽  
Author(s):  
Hideyuki Suzuki ◽  
M. S. Srinivasa Reddy ◽  
Marina Naoumkina ◽  
Naveed Aziz ◽  
Gregory D. May ◽  
...  
Keyword(s):  
Methyl Jasmonate ◽  
Cell Suspension ◽  
Medicago Truncatula ◽  
Cell Suspension Cultures ◽  
Suspension Cultures ◽  
Model Legume ◽  
Yeast Elicitor

scholarly journals Downregulation of key genes involved in carbon metabolism in Medicago truncatula results in increased lipid accumulation in vegetative tissue

Crop Science ◽  
2020 ◽  
Vol 60 (4) ◽  
pp. 1798-1808
Author(s):  
Champa Wijekoon ◽  
Stacy D. Singer ◽  
Randall J. Weselake ◽  
James R. Petrie ◽  
Guanqun Chen ◽  
...  
Keyword(s):  
Medicago Truncatula ◽  
Carbon Metabolism ◽  
Lipid Accumulation ◽  
Vegetative Tissue ◽  
Key Genes

scholarly journals MRE11 is crucial for malaria transmission and its absence affects expression of interconnected networks of key genes essential for life

2020 ◽  
Author(s):  
David S. Guttery ◽  
Abhinay Ramaprasad ◽  
David J. P. Ferguson ◽  
Mohammad Zeeshan ◽  
Rajan Pandey ◽  
...  
Keyword(s):  
Dna Damage Response ◽  
Plasmodium Berghei ◽  
Genome Stability ◽  
Malaria Parasite ◽  
Mosquito Vector ◽  
Parasite Transmission ◽  
Biological Processes ◽  
Cluster Assembly ◽  
Damage Response ◽  
Key Genes

AbstractThe Meiotic Recombination 11 protein (MRE11) plays a key role in DNA damage response and maintenance of genome stability. However, little is known about its function during development of the malaria parasite Plasmodium. Here, we present a functional, ultrastructural and transcriptomic analysis of Plasmodium MRE11 during its life-cycle in both mammalian and mosquito vector hosts. Genetic disruption of Plasmodium berghei mre11 (PbMRE11) results in significant retardation of oocyst development in the mosquito midgut associated with cytoplasmic and nuclear degeneration, along with concomitant ablation of sporogony and subsequent parasite transmission. Further, absence of PbMRE11 results in significant transcriptional downregulation of genes involved in key interconnected biological processes that are fundamental to all eukaryotic life including ribonucleoprotein biogenesis, spliceosome function and iron-sulphur cluster assembly. Overall, our study provides a comprehensive functional analysis of MRE11’s role in Plasmodium development during the mosquito stages and offers a potential target for therapeutic intervention during malaria parasite transmission.

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