Optimization of process parameters for improved production of bioactive metabolite by a novel endophytic fungus Fusarium sp. DF2 isolated from Taxus wallichiana of North East India

2007 ◽  
Vol 24 (1) ◽  
pp. 79-87 ◽  
Author(s):  
Dip K. Gogoi ◽  
Hari P. Deka Boruah ◽  
Ratul Saikia ◽  
Tarun C. Bora
Keyword(s):  
Process Parameters ◽  
Endophytic Fungus ◽  
Bioactive Metabolite ◽  
North East India ◽  
North East ◽  
Optimization Of Process Parameters ◽  
Fusarium Sp ◽  
Taxus Wallichiana

scholarly journals A study of the effect of Paclitaxel, Docetaxel and Tamoxifen citrate coumpounds found in Taxus wallichiana on the Beta-tubulin and Estrogen Receptor (ESR) proteins in humans using a bioinformatics approach

2019 ◽  
pp. 103-114
Author(s):  
Bikash Thakuria ◽  
Devatrisha Purkayastha ◽  
Samrat Adhikari
Keyword(s):  
Estrogen Receptor ◽  
Bioactive Compounds ◽  
Active Form ◽  
Docking Studies ◽  
North East India ◽  
North East ◽  
Tamoxifen Citrate ◽  
Protein Receptors ◽  
Cancerous Cells ◽  
Taxus Wallichiana

Taxus wallichiana, an indigenous plant of North East India contains bioactive compounds such as Tamoxifen citrate and taxol (paclitaxel and docetaxel) which inhibit the growth of cancerous cells. Tamoxifen citrate in its active form competitively inhibits the binding of estradiol or estrogen with estrogen receptor and results in tumor suppression whereas the taxol compounds stabilize the tubulin protein in microtubules and inhibit cell division in cancerous cells. In this approach, important domains and motifs of the protein receptors were studied and analyzed followed by homology modeling and its validation. Molecular docking studies were carried out via tubulin and estrogen receptor with paclitaxel, docetaxel, and endoxifen (an active form of tamoxifen citrate). Hence it was verified that tubulin and estrogen receptor contain binding sites for the bioactive compounds found in T. wallichiana and these bioactive compounds after binding with these receptors result in the prevention of the proliferation of the tumorous cells by stabilizing the microtubules and preventing the intake of steroidal hormones by cells respectively.

Past Verses Present; Metamorphosis in Different Spheres of Guwahati: A Study of Srutimala Duara’s Mindprints of Guwahati

2020 ◽  
Vol 8 (2) ◽  
pp. 13
Author(s):  
Ankita Pandey
Keyword(s):  
Point Of View ◽  
Areca Nut ◽  
Medieval Period ◽  
River Bank ◽  
North East India ◽  
North East ◽  
The North ◽  
Indian State ◽  
The City ◽  
Beautiful City

Guwahati derives its name from the Assamese word “Guwa” means areca nut and “Haat” means market. However, the modern Guwahati had been known as the ancient Pragjyotishpura and was the capital of Assam under the Kamrupa kingdom. A beautiful city Guwahati is situated on the south bank of the river Bramhaputra. Moreover, It is known as the largest city in the Indian state of Assam and also the largest metropolis in North East India. It has also its importance as the gateway to the North- East India. Assamese and English are the spoken languages in Guwahati.  In 1667, the Mogul forces were defeated in the battle by the Ahom forces commanded by Lachut Barphukan. Thus, in a sense Guwahati became the bone of contention among the Ahoms, Kochas and the Moguls during the medieval period.  Guwahati the administrative headquarters of Lower Assam with a viceroy or Barbhukan was made by the Ahom king.  Since 1972 it has been the capital of Assam. The present paper will discuss the changes happened in Guwahati over the period of late 1970s till the present time. It will focus on the behavior of people, transformed temples, Panbazar of the city, river bank of Bramhaputra, old Fancy Bazaar, chaotic ways, festivals and seasons including a fifth man made season etc. It will also deal how over the years a city endowed with nature’s gifts and scenic views, has been changing as “a dirty city”. Furthermore, it will also present the insurgencies that have barged into the city. The occurrence of changes will be discussed through the perspective and point of view of Srutimala Duara as presented in her book Mindprints of Guwahati.

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