Detection and Characterization of Sentinel Lymph Node by Ultrasound Molecular Imaging with B7-H3-Targeted Microbubbles in Orthotopic Breast Cancer Model in Mice

2021 ◽  
Author(s):  
Zhongqian Hu ◽  
Sunitha V. Bachawal ◽  
Xuelin Li ◽  
Huaijun Wang ◽  
Katheryne E. Wilson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Molecular Imaging ◽  
Sentinel Lymph Node ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Targeted Microbubbles ◽  
Ultrasound Molecular Imaging

scholarly journals Visualisation of Sentinel Lymph Node with Indium-Based near Infrared Emitting Quantum Dots in a Murine Metastatic Breast Cancer Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e44433 ◽  
Author(s):  
Marion Helle ◽  
Elsa Cassette ◽  
Lina Bezdetnaya ◽  
Thomas Pons ◽  
Agnès Leroux ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quantum Dots ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Near Infrared ◽  
Metastatic Breast ◽  
Cancer Model ◽  
Breast Cancer Model

scholarly journals 68Ga-Sienna+ for PET-MRI Guided Sentinel Lymph Node Biopsy: Synthesis and Preclinical Evaluation in a Metastatic Breast Cancer Model

2019 ◽  
Vol 3 (3) ◽  
pp. 255-265
Author(s):  
Heli Savolainen ◽  
Alessia Volpe ◽  
Alkystis Phinikaridou ◽  
Michael Douek ◽  
Gilbert Fruhwirth ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Metastatic Breast ◽  
Lymph Node Biopsy ◽  
Cancer Model ◽  
Preclinical Evaluation ◽  
Node Biopsy ◽  
Breast Cancer Model ◽  
Mri Guided

scholarly journals Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model

2017 ◽  
Vol 42 (1) ◽  
pp. 407-415 ◽  
Author(s):  
Lu Liang ◽  
Zhiwei Yue ◽  
Wei Du ◽  
Yang Li ◽  
Hongyan Tao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Imaging ◽  
Cell Survival ◽  
Real Time ◽  
Tumor Angiogenesis ◽  
Bioluminescence Imaging ◽  
Expression System ◽  
Cancer Model ◽  
Vegf Expression ◽  
Breast Cancer Model

Background: Tumor derived vascular endothelial growth factor (VEGF) can stimulate proliferation and migration of endothelial cells and recruit endothelial progenitor cells into tumors for vascular formation via a paracrine manner. Now increasing evidence suggests that VEGF also serves as an autocrine factor promoting cell survival and tumor angiogenesis. Real time visualization of VEGF activity in the early stages of tumor formation using molecular imaging will provide unprecedented insight into the biological processes of cancer. Methods: The mouse breast cancer cell line 4T1 was transfected with an inducible, bidirectional tetracycline (Bi-Tet) promoter driving VEGF and renilla luciferase (Rluc). This was used to quantitatively image conditional switching of VEGF by bioluminescence imaging (BLI) under the control of systemic administration of doxycycline. Simultaneously, 4T1 cells were labelled with the double fusion reporter gene (Fluc-eGFP) to establish a breast cancer model. Results: We found that inducible VEGF could promote proliferation and attenuate apoptosis due to oxidative stress in an autocrine manner in vitro. In vivo studies revealed that induction of VEGF expression during early tumor development not only dramatically enhanced tumor growth but also increased tumor angiogenesis as visualized by BLI. Finally, immunohistochemistry staining confirmed that inducing VEGF expression promoted cell survival and tumor neovascularization. Conclusion: Together the inducible bidirectional tetracycline (Bi-Tet) co-expression system combined with the dual bioluminescence imaging (BLI) system provides a platform to investigate a target gene’s role in the pathologic process of cancer and facilitates noninvasive monitoring of biological responses in real time.

Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model

2013 ◽  
Vol 31 (3) ◽  
pp. 351-365 ◽  
Author(s):  
Luca Quagliata ◽  
Sandra Klusmeier ◽  
Natascha Cremers ◽  
Bronislaw Pytowski ◽  
Alfred Harvey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Node Metastases ◽  
Draining Lymph Nodes

scholarly journals Abstract 2918: Characterization of a novel transplantable C3TAg breast cancer model in C57BL/6J mice

2021 ◽  
Author(s):  
Meredith S. Carson ◽  
Michael F. Colman ◽  
Daniel Roth ◽  
Jody Albright ◽  
Melissa VerHague ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Model ◽  
Breast Cancer Model

8 Characterization of Activated Stroma Cells and Externalized Proteins in 3D Human Breast Cancer Model

Apmis ◽  
2008 ◽  
Vol 116 (5) ◽  
pp. 421-421
Author(s):  
Charlotta J. Olsen ◽  
Noona Ambartsumian ◽  
José Moreira ◽  
Julio E. Celis ◽  
Eugene Lukanidin
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Cancer Model ◽  
Human Breast ◽  
Breast Cancer Model

scholarly journals Visualization of angiogenesis during cancer development in the polyoma middle T breast cancer model: molecular imaging with (R)-[11C]PAQ

2014 ◽  
Vol 4 (1) ◽  
pp. 17 ◽  
Author(s):  
Erik Samén ◽  
Li Lu ◽  
Jan Mulder ◽  
Jan-Olov Thorell ◽  
Peter Damberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Imaging ◽  
Cancer Development ◽  
Cancer Model ◽  
Breast Cancer Model
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