Perceived stress and sleep quality before oocyte pick-up, embryo transfer, and pregnancy test in women receiving in vitro fertilization treatment

2021 ◽  
Author(s):  
Nurcan Kirca ◽  
Meryem Ongen
Keyword(s):  
In Vitro Fertilization ◽  
Sleep Quality ◽  
Embryo Transfer ◽  
Perceived Stress ◽  
Pregnancy Test ◽  
Vitro Fertilization

O-167 Sleep quality and affecting factors in women undergoing in vitro fertilization treatment

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
F Yanık ◽  
M Alus Tokat
Keyword(s):  
In Vitro Fertilization ◽  
Sleep Quality ◽  
Treatment Period ◽  
Embryo Transfer ◽  
Physical Symptoms ◽  
Prolonged Treatment ◽  
Affecting Factors ◽  
Vitro Fertilization ◽  
Pre Treatment

Abstract Study question Does in vitro fertilization (IVF) treatment affects the sleep quality of women and which factors reduce the sleep quality in different stages of this treatment? Summary answer The sleep quality decreased as the IVF treatment process progresses. Advanced age, prolonged treatment, economical concerns, stress ect. were factors that adversely affected women sleep. What is known already According to worldwide research, women receiving IVF treatment may suffer from physiological and psychological symptoms and even experience sleep disturbance. Sleep disturbances are thought to be frequent in women undergoing IVF despite minimal research of this hypothesis. The literature emphasizes the positive effect of quality sleep on oocyte health. Especially sleep hormone melatonin is effective in development of oocytes quality. During sleep, hormones such as melatonin and growth hormone can protect oocytes from the effects of harmful metabolites and improve oocyte quality. Routine evaluation of sleep quality and affecting factors may be an important issue in women receiving IVF treatment. Study design, size, duration It was longitudinal study with repeated measures. The sample consisted of 158 women from 218 eligible patients who received IVF treatment in two infertility centers in Izmir between December 2017 and March 2019. Treatment-related side effects, cancellation of embryo transfer, and women could not be reached after embryo transfer were excludation reasons. According to the statistical analysis, the effect size was calculated as 0.496 and the statistical power as 100%. Participants/materials, setting, methods Data were collected via a structured questionnaires, “The Descriptive Data Form”, “Pittsburgh Sleep Quality Index”, “Visual Analog Stress Scale” and “Treatment Related Physical Symptoms List”. The sleep quality and effecting factors were evaluated in three stages; the data related to pre-treatment period in beginning of IVF trial, in oocyte pick up (OPU) day induction-OPU process data and 1-2 days before pregnancy test, post embryo transfer data were collected. Main results and the role of chance The average sleep quality score was 6.96 in the pre-treatment period, 8.03 in the induction-oocyte pick up process, and 8.87 in the post embryo transfer (p < 0.001), the higher score it is evaluated as lower sleep quality. There was also a strong positive correlation between the stress scores and sleep quality before and during the treatment periods (r = 7.638 p < 0.001, r = 0.672 p < 0.001, r = 0.694 p < 0.001). Among the descriptive features; advanced age, low education level, shift work, prolonged marriage duration, among infertility features; prolonged treatment, female and male factor, economic distress and sleep habit; such as being exposed to light were associated with poorer sleep quality (p < 0.001). Related to physical symptoms such as the abdominal distention, abdominal pain and breast fullness observed induction-OPU period (t = 4.79 p= .00, t = 2.93 p= .00, t = 2.77 p= .00) and besides nausea and fatigue in post embryo transfer period where symptoms that significantly affect sleep quality (t = 9.38 p= .00, t = 4.20 p= .00, t = 4.06 p= .00, t = 4.27 p= .00, t = 4.33 p= .00). According to results it was determined that women sleep quality decrease along with progress of IVF trial. Consequently health professionals should assess women’s sleep quality and give support in most risky periods. Limitations, reasons for caution The fact that some women cannot be reached by phone after embryo transfer during the data collection process can be shown as the limitations of the study. At the same time, the subjective evaluation of sleep quality can be expressed as another limitation of the study. Wider implications of the findings There is a need for an experimental, randomized controlled study with objective evaluation of sleep outcomes. Therewithal examining the effect of sleep outcomes on the oocytes quality and pregnancy rates will guide clinical practise during IVF and other assisted reproductive treatments. Trial registration number There is no number

Waiting for pregnancy test results following in vitro fertilization and embryo transfer (IVF/ET) or intrauterine insemination (IUI): will giving patients a card help them cope?

2012 ◽  
Vol 98 (3) ◽  
pp. S46 ◽  
Author(s):  
L.S. Covington ◽  
C.B. Toll ◽  
P. Sachs ◽  
E.J. Mindes ◽  
M.H. Deweese ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Intrauterine Insemination ◽  
Test Results ◽  
Pregnancy Test ◽  
Vitro Fertilization ◽  
Ivf Et

scholarly journals Should rescue ICSI be re-evaluated considering the deferred transfer of cryopreserved embryos in in-vitro fertilization cycles? A systematic review and meta-analysis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Alessio Paffoni ◽  
Marco Reschini ◽  
Valerio Pisaturo ◽  
Cristina Guarneri ◽  
Simone Palini ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Implantation Rate ◽  
Clinical Pregnancy ◽  
Frozen Embryo Transfer ◽  
Fertilization Failure ◽  
Vitro Fertilization ◽  
Rescue Icsi

Abstract Background Total fertilization failure represents a particularly frustrating condition for couples undergoing in vitro fertilization. With the aim of reducing the occurrence of total fertilization failure, intracytoplasmic sperm injection (ICSI) has become the first choice over conventional in vitro fertilization (IVF) procedures although evidence of improved results is still debated and its use in couples without male factor infertility is not recommended. Among the strategies potentially useful to promote the use of conventional IVF, we herein call attention to the late rescue ICSI, which consists in performing ICSI after 18–24 h from conventional insemination on oocytes that show no signs of fertilization. This treatment has however been reported to be associated with a low success rate until recent observations that embryos derived from late rescue ICSI may be transferred after cryopreservation in a frozen-thawed cycle with improved results. The aim of the present study was to assess whether frozen embryos deriving from rescue ICSI performed about 24 h after conventional IVF may represent a valuable option for couples experiencing fertilization failure. Methods A systematic review on the efficacy of late rescue ICSI was performed consulting PUBMED and EMBASE. Results Including twenty-two original studies, we showed that clinical pregnancy rate per embryo transfer and implantation rate obtainable with fresh embryo transfers after rescue ICSI are not satisfactory being equal to 10 and 5%, respectively. The transfer of cryopreserved rescue ICSI embryos seems to offer a substantial improvement of success rates, with pregnancy rate per embryo transfer and implantation rate equal to 36 and 18%, respectively. Coupling rescue ICSI with frozen embryo transfer may ameliorate the clinical pregnancy rate for embryo transfer with an Odds Ratio = 4.7 (95% CI:2.6–8.6). Conclusion Results of the present review support the idea that r-ICSI coupled with frozen embryo transfer may overcome most of the technical and biological issues associated with fresh transfer after late r-ICSI, thus possibly representing an efficient procedure for couples experiencing fertilization failure following conventional IVF cycles. Trial registration Prospero registration ID: CRD42021239026.

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