Design, synthesis, and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs

2014 ◽  
Vol 57 (6) ◽  
pp. 807-822 ◽  
Author(s):  
HuiZhen Zhang ◽  
JianMei Lin ◽  
Syed Rasheed ◽  
ChengHe Zhou
Keyword(s):  
Synergistic Effects ◽  
Biological Evaluation ◽  
Calf Thymus Dna ◽  
Benzimidazole Derivatives ◽  
Design Synthesis ◽  
Calf Thymus ◽  
Clinical Drugs ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity

2010 ◽  
Vol 33 (7) ◽  
pp. 971-980 ◽  
Author(s):  
Priyal Jain ◽  
Prakash Kumar Sharma ◽  
Harish Rajak ◽  
Rajesh Singh Pawar ◽  
Umesh Kumar Patil ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Biological Evaluation ◽  
Benzimidazole Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation

RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 37092-37100
Author(s):  
Vegard Torp Lien ◽  
Margrethe Konstanse Kristiansen ◽  
Solveig Pettersen ◽  
Mads Haugland Haugen ◽  
Dag Erlend Olberg ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Small Molecules ◽  
Signaling Pathway ◽  
Synergistic Effects ◽  
Wnt Signaling Pathway ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation

Dual inhibitors of MET and WNT signaling may have synergistic effects, and the design, synthesis and evaluation of such first-in-class small-molecules are reported.

scholarly journals Design, synthesis and biological evaluation of 3′,4′,5′-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents

MedChemComm ◽  
2018 ◽  
Vol 9 (2) ◽  
pp. 305-315 ◽  
Author(s):  
Zhe Wang ◽  
Xiangping Deng ◽  
Runde Xiong ◽  
Shujuan Xiong ◽  
Juan Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Benzimidazole Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

A series of 3′,4′,5′-trimethoxy flavonoids with benzimidazole linked by different chain alkanes have been designed and synthesized.

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