scholarly journals Destination Brain: the Past, Present, and Future of Therapeutic Gene Delivery

2017 ◽  
Vol 12 (1) ◽  
pp. 51-83 ◽  
Author(s):  
Chaitanya R. Joshi ◽  
Vinod Labhasetwar ◽  
Anuja Ghorpade
Keyword(s):  
Gene Delivery ◽  
Therapeutic Gene ◽  
The Past

scholarly journals A mini-review of Nanocarriers in drug delivery systems Nanocarriers in drug delivery systems

2021 ◽  
Author(s):  
Mahsa Mazdaei ◽  
Kofi Asare-Addo
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Cancer Chemotherapy ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Therapeutic Gene ◽  
Solid Lipid ◽  
The Past

The application of nanotechnology indrug delivery systems (DDS) has been researched widely and seen an advancementover the past three decades. Since the 1970s, nanoparticles were primarilyutilised in vaccine deliveries and cancer chemotherapy. In more recent years,they have been found to hold promises for broader applications such as inproteins and therapeutic gene delivery systems. To date, there have been only ahandful of nanocarrier-loaded drugs commercialised into the pharmaceuticalmarket. More research is thus needed to facilitate a breakthrough of theseproducts into the current market. This mini-review mainly focuses on four typesof commonly utilised organic nanocarriers including micelles, compactpolymerics, solid-lipid nanoparticles and liposomal vesicles and discusses theprogress and some challenges associated with these nanoparticles (NP). 

Polyplex: A Promising Gene Delivery System

2019 ◽  
Vol 12 (6) ◽  
pp. 4681-4686
Author(s):  
Rohan Aggarwal ◽  
Monika Targhotra ◽  
Bhumika Kumar ◽  
P.K Sahoo ◽  
Meenakshi K Chauhan
Keyword(s):  
Gene Transfer ◽  
Gene Delivery ◽  
Delivery System ◽  
Viral Vectors ◽  
Gene Delivery System ◽  
Cationic Polymers ◽  
Therapeutic Application ◽  
Promising Alternative ◽  
Structure And Stability ◽  
The Past

In the past few years gene delivery system has gained a huge attention owing to its proved efficacy in several diseases especially in those caused by genetic and/oroncological malfunctioning. The effective gene delivery mainly depends on the carrier molecules that can ensure the safe and specific delivery of the nucleic acidmolecules. Viral vectors have been used for a longer period as the gene transfer vehicle. However, these viral vectors have potential immunological disadvantages that made them less preferred. Recently, non-viral vectors such as polyplexes have emerged as a promising alternative for viral vectors. Polyplexes are formed by conjugating a polymer with DNA and in maximum cases the cationic polymers are preferred over others. The structure and stability of the polyplexes depends on various factors. The ability of the polymer to condense the DNA mainly dictates the efficiency of the polyplex mediated transfection. In this review we are going to provide a framework for the synthesis and design of the polyplexes along with the structure and stability of the complexes pertaining to mechanism of action, characterization and therapeutic application, including polyethyleneimine mediated cytotoxicity as well as newer strategies for the generation of better polyplexes.

Therapeutic gene delivery in human B-lymphoblastoid cells by engineered non-transforming infectious Epstein–Barr virus

1995 ◽  
Vol 1 (12) ◽  
pp. 1303-1308 ◽  
Author(s):  
Subrata Banerjee ◽  
Elizabeth Livanos ◽  
Jean-Michel H. Vos
Keyword(s):  
Gene Delivery ◽  
Epstein Barr Virus ◽  
Therapeutic Gene ◽  
Lymphoblastoid Cells ◽  
Barr Virus ◽  
Epstein Barr

Magnetic nanoparticles for targeted therapeutic gene delivery and magnetic-inducing heating on hepatoma

2014 ◽  
Vol 25 (34) ◽  
pp. 345101 ◽  
Author(s):  
Chenyan Yuan ◽  
Yanli An ◽  
Jia Zhang ◽  
Hongbo Li ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Gene Delivery ◽  
Therapeutic Gene ◽  
Targeted Therapeutic

Irradiation promotes Akt-targeting therapeutic gene delivery to the tumor vasculature

2007 ◽  
Vol 67 (4) ◽  
pp. 1155-1162 ◽  
Author(s):  
Pierre Sonveaux ◽  
Françoise Frérart ◽  
Caroline Bouzin ◽  
Agnès Brouet ◽  
Julie DeWever ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Tumor Vasculature ◽  
Therapeutic Gene
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