scholarly journals Multicentric Giant Cell Tumor of the Fourth and Fifth Metacarpals with Lung Metastases

Hand ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. 389-392 ◽  
Author(s):  
Nash H. Naam ◽  
Steven L. Jones ◽  
Justin Floyd ◽  
Esat I. Memisoglu
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastases ◽  
Cell Tumor

Bilateral Lung Metastases From a Phalangeal Giant Cell Tumor of Bone

2020 ◽  
pp. 109352662096435
Author(s):  
Annie Orr ◽  
Huifei Liu ◽  
Rachel Mariani ◽  
Jennifer H Aldrink ◽  
Bhuvana A Setty ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Residual Disease ◽  
Lung Metastases ◽  
Transcriptome Profiling ◽  
Cell Tumor ◽  
Wide Resection ◽  
Genetic Changes ◽  
Metastatic Lung ◽  
Bilateral Lung

We describe a rare pediatric case of a phalangeal giant cell tumor of bone with extensive bilateral lung metastases following curettage, wide resection, and amputation. Concurrent peripheral blood eosinophilia and pleural effusion with marked eosinophilia (47%) were present. To discover genetic changes driving tumor metastasis, genomic and transcriptome profiling of the metastatic lung mass as well as germline analysis were performed. Whole exome sequencing detected a histone H3F3A p.G35V missense mutation in tumor cells. RNA sequencing revealed overexpression of receptor activator of nuclear factor kappa-B ligand (RANKL). The patient is alive with no residual disease and uncompromised respiratory function 29 months after amputation of primary tumor and 19 months after surgical resection of his metastatic lung disease.

scholarly journals Characteristics Giant Cell Tumor of The Bone Cases at Dr. Mohammad Hoesin General Hospital Period 1 January 2017 - 31 Augsut 2020

2021 ◽  
Vol 5 (3) ◽  
pp. 546-552
Author(s):  
Primadika Rubiansyah ◽  
Randy Rakhmat Septiandani
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
General Hospital ◽  
Lung Metastases ◽  
Cell Tumor ◽  
Primary Bone Tumor ◽  
Grade Ii ◽  
Male Patients ◽  
Group 2 ◽  
Short Time

Introduction : Giant Cell Tumor (GCT) is a benign bone tumors with potentially aggressive and capacity to metastasize. This tumor could destroy the bone and joint component. As a primary bone tumor that appears at productive age , GCT can cause morbidity for patients. Methods : This research is a retrospective descriptive study with data obtained from the medical records of patients who went to Mohammad Hoesin general hospital for the period January 1, 2017- August 31, 2019. Data processing was carried out using SPSS 16.0. From the research results, 27 GCT patient data that met the inclusion criteria were obtained. Results : There were 23 (85.1%) patients in the 20-44 years age group, 2 (7.4%) people <20 years, 2 (7.4%) people> 44 years. There were 13 (48%) male patients and 14 (52%) female patients. The most common tumor locations were in the proximal tibia as many as 6 (22%) people, Distal Femur as many as 6 (22%) people, Distal Radius as many as 5 (18.5%) people, Distal Ulna as many as 3 (11.1%) people, Proximal Femur as many as 1 (3.7 %) people, Calcaneus as much as 1 (3.7%) people, Metacarpal as many as 1 (3.7%) people. Based on grading Campanacci, 16 (59.25%) people had GCT with Campanacci Grade III, Grade II with 8 (29.6%) people, and 1 (3.7%) grade I. Only 2 (7.4%) people had recurrences. No patients were found to have lung metastases (0%). There were 1 (3.7%) patients with pathological fracture on GCT. Management carried out was 24 people undergoing resection and reconstruction 24 (88.5%) and 3 (11.5%) people with curettage and bone cement. Conclusion : This study of GCTB at Mohammad Hoesin general hospital bring out that patient’s characteristics are similar with other country and theory. Mostly patient got GCTB at age second until fouth decade of life, slightly more in female, mostly tumor detected around the knee. Mostly patient detected with Campanacci graded III and needed resection and reconstruction surgery. No reported lung metastases in GCTB patient but this record need further follow up due to short time between surgery and study

Metastasectomy Versus Non-Metastasectomy for Giant Cell Tumor of Bone Lung Metastases

Orthopedics ◽  
2021 ◽  
pp. 1-6
Author(s):  
Shinji Tsukamoto ◽  
Andreas F. Mavrogenis ◽  
Yuu Tanaka ◽  
Akira Kido ◽  
Kanya Honoki ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastases ◽  
Cell Tumor

Arthroscopic Management of Giant Cell Tumor of the Calcaneus

2021 ◽  
pp. 193864002110291
Author(s):  
I Gede Eka Wiratnaya ◽  
I Wayan Subawa ◽  
Putu Astawa ◽  
Hans Kristian Nugraha
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
High Speed ◽  
Lung Metastases ◽  
Weight Bearing ◽  
Cell Tumor ◽  
Lytic Lesion ◽  
Full Weight Bearing ◽  
Recurrent Pain ◽  
Retrospective Case

Giant cell tumor of the calcaneal bone is a very rare entity and generally seen in the 30 to 40 years age group. We report a case of a 17-year-old male with giant cell tumor of the calcaneus, presented with left heel pain without another obvious physical abnormality. Radiographs showed a lobulated, well-defined, lytic lesion of the calcaneus with narrow transitional zone without periosteal reaction, no extraosseal spread, and no lung metastases. Arthroscopic procedure was done directly for both diagnostic and curative procedures. All soft, grayish lesions were completely removed arthroscopically using direct lateral portals and the suspected reactive zones debrided using high-speed burr and injected with corticosteroid. Histopathology confirmed the suspected diagnosis. The postoperative clinical course was uneventful with immediate pain relief and full weight bearing and movement allowed soon. The patient had no recurrent pain as well as recurrent radiographic lesions, and normal joint mobility 9 months postoperatively. Considering the accessibility of the lesion, giant cell tumor of the calcaneal bone can be successfully treated arthroscopically using direct lateral approach. Levels of Evidence: Therapeutic, Level IV: Retrospective, case report

scholarly journals Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature

2021 ◽  
Vol 11 ◽  
Author(s):  
Wenxiang Zhang ◽  
Xiangyi Kong ◽  
Yihang Qi ◽  
Xiangyu Wang ◽  
Qiang Liu ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Tumor ◽  
Breast Tumor ◽  
Lung Metastases ◽  
Left Breast ◽  
Cell Tumor

Giant cell tumor of soft tissue (GCT-ST) is an extremely rare tumor that is similar in morphology and immunohistochemistry to giant cell tumor of the bone. Almost 80% of these tumors occur in the upper and lower extremities, and the breast is a very rare location. Here, we report a case of a 65-year-old female patient with a small mobile palpable lump in the left breast. Although the left breast tumor was considered malignant on preoperative imaging, no evidence of malignant tumor was found by ultrasound-guided core needle biopsy (CNB). Subsequently, the left breast tumor was confirmed as a malignant tumor by intraoperative rapid pathological examination. The initial treatment of the tumor was wide local excision and sentinel lymph node biopsy, and it was confirmed to be GCT-ST by histopathology and immunohistochemistry. Despite surgical treatment achieving clear surgical margins, the patient experienced lung metastases within a year of her initial treatment. Fortunately, the patient underwent surgical treatment of lung metastases, and at the last follow-up, the patient was still alive. This is the first case of a primary soft tissue tumor of the breast that has undergone surgical intervention after lung metastasis. This case report highlights the complexity of the clinical diagnosis and treatment of GCT-ST arising from the breast. Surgery may be another good treatment when the patient develops lung metastases.

Experience using denosumab for lung metastases of giant cell tumor of bone

2015 ◽  
Vol 6 (3) ◽  
pp. 239-241
Author(s):  
Yuto Watanabe ◽  
Mitsunori Kaya ◽  
Mikito Sasaki ◽  
Masato Emori ◽  
Yasutaka Murahashi ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastases ◽  
Cell Tumor

scholarly journals Similar outcomes with first-line observation versus metastasectomy for bone giant cell tumor lung metastases

2020 ◽  
Author(s):  
Shinji Tsukamoto ◽  
Giovanni Ciani ◽  
Andreas F. Mavrogenis ◽  
Cristina Ferrari ◽  
Manabu Akahane ◽  
...  
Keyword(s):  
Disease Progression ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastases ◽  
Progression Free Survival ◽  
Cell Tumor ◽  
First Line ◽  
Free Survival ◽  
Line Management

Abstract Background: The outcome of lung metastases in patients with giant cell tumor of bone (GCTB) varies from spontaneous regression to uncontrolled growth. To investigate whether observation is an appropriate first-line management for patients with lung metastases from GCTB, we compared the outcomes of patients initially treated with observation with those treated with metastasectomy.Methods: We retrospectively reviewed the data of 29 patients with lung metastases from histologically confirmed GCTB. The median follow-up period was 114 months. We evaluated progression-free survival, which was defined as the time from the date of occurrence of lung metastases to the date of disease progression in the observation or incomplete metastasectomy group, disease recurrence in the complete metastasectomy group, or the last follow-up.Results: Disease progression or recurrence occurred in 14 patients (48.3%). Progression-free survival did not vary significantly between the observation and metastasectomy groups (p=0.373). The number of metastasectomies was significantly higher in the initial metastasectomy group than in the observation group (p=0.017).Conclusions: Observation can be used safely as first-line management for patients with lung metastases from GCTB with an outcome similar to that of metastasectomy.

scholarly journals Growth rate analysis of lung metastases from histologically benign giant cell tumor of Bone

Cancer ◽  
1987 ◽  
Vol 59 (10) ◽  
pp. 1831-1836 ◽  
Author(s):  
Eliezer Katz ◽  
Meir Nyska ◽  
Elimelech Okon ◽  
Gershom Zajicek ◽  
Gordon Robin
Keyword(s):  
Growth Rate ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastases ◽  
Cell Tumor ◽  
Rate Analysis

scholarly journals Similar outcomes with first-line observation versus metastasectomy for bone giant cell tumor lung metastases

2020 ◽  
Author(s):  
Shinji Tsukamoto ◽  
Giovanni Ciani ◽  
Andreas F. Mavrogenis ◽  
Cristina Ferrari ◽  
Manabu Akahane ◽  
...  
Keyword(s):  
Disease Progression ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastases ◽  
Progression Free Survival ◽  
Cell Tumor ◽  
First Line ◽  
Free Survival ◽  
Number Of Patients

Abstract Background: The outcome of lung metastases in patients with giant cell tumor of bone (GCTB) varies from spontaneous regression to uncontrolled growth. To investigate whether observation is an appropriate first-line management for patients with lung metastases from GCTB, we compared the outcomes of patients initially treated with observation with those treated with metastasectomy.Methods: We retrospectively reviewed the data of 29 patients with lung metastases from histologically confirmed GCTB. The median follow-up period was 114 months. We evaluated progression-free survival, which was defined as the time from the date of occurrence of lung metastases to the date of disease progression in the observation or incomplete metastasectomy group, disease recurrence in the complete metastasectomy group, or the last follow-up.Results: Disease progression or recurrence occurred in 14 patients (48.3%). Progression-free survival did not vary significantly between the observation and metastasectomy groups (p=0.373). The total number of metastasectomies was significantly higher in the initial metastasectomy group than in the observation group (p=0.017).Conclusions: The number of patients included in this study is small, however the data suggests that observation can be used safely as first-line management for patients with lung metastases from GCTB with an outcome similar to that of metastasectomy. It is necessary to confirm our result in multi-institutional study with sufficient number of patients.

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