scholarly journals Characteristics Giant Cell Tumor of The Bone Cases at Dr. Mohammad Hoesin General Hospital Period 1 January 2017 - 31 Augsut 2020

2021 ◽  
Vol 5 (3) ◽  
pp. 546-552
Author(s):  
Primadika Rubiansyah ◽  
Randy Rakhmat Septiandani
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
General Hospital ◽  
Lung Metastases ◽  
Cell Tumor ◽  
Primary Bone Tumor ◽  
Grade Ii ◽  
Male Patients ◽  
Group 2 ◽  
Short Time

Introduction : Giant Cell Tumor (GCT) is a benign bone tumors with potentially aggressive and capacity to metastasize. This tumor could destroy the bone and joint component. As a primary bone tumor that appears at productive age , GCT can cause morbidity for patients. Methods : This research is a retrospective descriptive study with data obtained from the medical records of patients who went to Mohammad Hoesin general hospital for the period January 1, 2017- August 31, 2019. Data processing was carried out using SPSS 16.0. From the research results, 27 GCT patient data that met the inclusion criteria were obtained. Results : There were 23 (85.1%) patients in the 20-44 years age group, 2 (7.4%) people <20 years, 2 (7.4%) people> 44 years. There were 13 (48%) male patients and 14 (52%) female patients. The most common tumor locations were in the proximal tibia as many as 6 (22%) people, Distal Femur as many as 6 (22%) people, Distal Radius as many as 5 (18.5%) people, Distal Ulna as many as 3 (11.1%) people, Proximal Femur as many as 1 (3.7 %) people, Calcaneus as much as 1 (3.7%) people, Metacarpal as many as 1 (3.7%) people. Based on grading Campanacci, 16 (59.25%) people had GCT with Campanacci Grade III, Grade II with 8 (29.6%) people, and 1 (3.7%) grade I. Only 2 (7.4%) people had recurrences. No patients were found to have lung metastases (0%). There were 1 (3.7%) patients with pathological fracture on GCT. Management carried out was 24 people undergoing resection and reconstruction 24 (88.5%) and 3 (11.5%) people with curettage and bone cement. Conclusion : This study of GCTB at Mohammad Hoesin general hospital bring out that patient’s characteristics are similar with other country and theory. Mostly patient got GCTB at age second until fouth decade of life, slightly more in female, mostly tumor detected around the knee. Mostly patient detected with Campanacci graded III and needed resection and reconstruction surgery. No reported lung metastases in GCTB patient but this record need further follow up due to short time between surgery and study

scholarly journals Characteristics Giant Cell Tumor of The Bone Cases at Dr. Mohammad Hoesin General Hospital Period 1 January 2017 - 31 Augsut 2020

2021 ◽  
Vol 5 (5) ◽  
pp. 493-499
Author(s):  
Primadika Rubiansyah ◽  
Randy Rakhmat Septiandani
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
General Hospital ◽  
Lung Metastases ◽  
Cell Tumor ◽  
Primary Bone Tumor ◽  
Grade Ii ◽  
Male Patients ◽  
Group 2 ◽  
Short Time

Introduction : Giant Cell Tumor (GCT) is a benign bone tumors with potentially aggressive and capacity to metastasize. This tumor could destroy the bone and joint component. As a primary bone tumor that appears at productive age , GCT can cause morbidity for patients. Methods : This research is a retrospective descriptive study with data obtained from the medical records of patients who went to Mohammad Hoesin general hospital for the period January 1, 2017- August 31, 2019. Data processing was carried out using SPSS 16.0. From the research results, 27 GCT patient data that met the inclusion criteria were obtained. Results : There were 23 (85.1%) patients in the 20-44 years age group, 2 (7.4%) people <20 years, 2 (7.4%) people> 44 years. There were 13 (48%) male patients and 14 (52%) female patients. The most common tumor locations were in the proximal tibia as many as 6 (22%) people, Distal Femur as many as 6 (22%) people, Distal Radius as many as 5 (18.5%) people, Distal Ulna as many as 3 (11.1%) people, Proximal Femur as many as 1 (3.7 %) people, Calcaneus as much as 1 (3.7%) people, Metacarpal as many as 1 (3.7%) people. Based on grading Campanacci, 16 (59.25%) people had GCT with Campanacci Grade III, Grade II with 8 (29.6%) people, and 1 (3.7%) grade I. Only 2 (7.4%) people had recurrences. No patients were found to have lung metastases (0%). There were 1 (3.7%) patients with pathological fracture on GCT. Management carried out was 24 people undergoing resection and reconstruction 24 (88.5%) and 3 (11.5%) people with curettage and bone cement. Conclusion : This study of GCTB at Mohammad Hoesin general hospital bring out that patient’s characteristics are similar with other country and theory. Mostly patient got GCTB at age second until fouth decade of life, slightly more in female, mostly tumor detected around the knee. Mostly patient detected with Campanacci graded III and needed resection and reconstruction surgery. No reported lung metastases in GCTB patient but this record need further follow up due to short time between surgery and study

scholarly journals Giant Cell Tumor of Bone, current treatments, and potential therapeutic alternatives

2020 ◽  
pp. 13
Author(s):  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Research Work ◽  
Cell Tumor ◽  
Treatment Modalities ◽  
Malignant Degeneration ◽  
Primary Malignancy ◽  
Primary Bone Tumor ◽  
Advantages And Disadvantages ◽  
Therapeutic Alternatives

Giant cell tumor of bone (GCTB) is a primary bone tumor, locally aggressive. For many, a GCTB is considered a tumor with an unpredictable behavior, particularly regarding recurrences, pulmonary implants, and the possibility of primary malignancy. In terms of risk of recurrence, it is known that it is associated with the type of treatment used initially for the GCTB. The greater the number or recurrences, the greater the risk of pulmonary implants, and the greater the risk of malignant degeneration. Therefore, much of the prognosis of this tumor could be related to the type of initial treatment. Hence the importance of the treatment theme. This review includes a comparison between the various modalities for treatment in GCTB, considering the advantages and disadvantages of each one. Existing GCTB treatments are not 100% safe and effective at the same time. and this is the reason why the search for other treatment modalities should continue to offer a better oncologic and functional outcome to patients. In the end of this review, based on research work, we also mention other possible therapeutic options that could be explored and used in the future for GCT treatment.

Bilateral Lung Metastases From a Phalangeal Giant Cell Tumor of Bone

2020 ◽  
pp. 109352662096435
Author(s):  
Annie Orr ◽  
Huifei Liu ◽  
Rachel Mariani ◽  
Jennifer H Aldrink ◽  
Bhuvana A Setty ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Residual Disease ◽  
Lung Metastases ◽  
Transcriptome Profiling ◽  
Cell Tumor ◽  
Wide Resection ◽  
Genetic Changes ◽  
Metastatic Lung ◽  
Bilateral Lung

We describe a rare pediatric case of a phalangeal giant cell tumor of bone with extensive bilateral lung metastases following curettage, wide resection, and amputation. Concurrent peripheral blood eosinophilia and pleural effusion with marked eosinophilia (47%) were present. To discover genetic changes driving tumor metastasis, genomic and transcriptome profiling of the metastatic lung mass as well as germline analysis were performed. Whole exome sequencing detected a histone H3F3A p.G35V missense mutation in tumor cells. RNA sequencing revealed overexpression of receptor activator of nuclear factor kappa-B ligand (RANKL). The patient is alive with no residual disease and uncompromised respiratory function 29 months after amputation of primary tumor and 19 months after surgical resection of his metastatic lung disease.

scholarly journals Multicentric Giant Cell Tumor of the Fourth and Fifth Metacarpals with Lung Metastases

Hand ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. 389-392 ◽  
Author(s):  
Nash H. Naam ◽  
Steven L. Jones ◽  
Justin Floyd ◽  
Esat I. Memisoglu
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastases ◽  
Cell Tumor

Metastasectomy Versus Non-Metastasectomy for Giant Cell Tumor of Bone Lung Metastases

Orthopedics ◽  
2021 ◽  
pp. 1-6
Author(s):  
Shinji Tsukamoto ◽  
Andreas F. Mavrogenis ◽  
Yuu Tanaka ◽  
Akira Kido ◽  
Kanya Honoki ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lung Metastases ◽  
Cell Tumor

scholarly journals Primary Giant Cell Tumor of the Axis: a Case Report

2021 ◽  
Author(s):  
Peng Wang ◽  
Chunhao Song ◽  
Cong Chen ◽  
Bo Liu ◽  
Jun Jia ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tumor Grade ◽  
Cell Tumor ◽  
The Body ◽  
Rare Type ◽  
Histologic Evaluation ◽  
Giant Tumor ◽  
X Ray Computed ◽  
Grade Ii

Abstract Background: Primary giant cell tumor of the axis is a rare. The authors reported a case of a primary giant cell tumor of the axis revealed by cervical pain, and discussed the diagnosis and treatment of giant cell tumor.Case presentation: The patient presented to our clinic with neck pain and unstable gait. X-ray, computed tomography and magnetic resonance imaging showed osteolysis of the body and vertebral arch of the axis. Histologic evaluation gave a conclusion of a giant tumor, grade II. Spondylectomy of the axis was performed by the transoral approach. The local recurrence of the tumor was found 3 months later and the patient refused further therapy.Conclusion: Primary giant cell tumor of the axis is a rare type tumor with poor prognosis. Definitive diagnosis should be based on histopathological morphology and surgical treatment should be performed as soon as possible.

scholarly journals Giant cell tumor of the frontal sinus: case report

2017 ◽  
Vol 3 (3) ◽  
pp. 725 ◽  
Author(s):  
Ali Alzarei ◽  
Majed Assiri ◽  
Rabab N. B. ◽  
Wael Aljoraebi ◽  
Ibrahim Sumaily
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Frontal Sinus ◽  
Frontal Bone ◽  
Cell Tumor ◽  
Primary Bone Tumor ◽  
Histopathological Images ◽  
Primary Bone ◽  
Work Up ◽  
Firm Mass

Giant cell tumor (GCT) is an uncommon aggressive primary bone tumor usually affects long bones. It is rarely involving skull bones, and to less extent the frontal bone. Up to date only 3 adult cases reported of the frontal bone, only one of them was occupying the frontal sinus. Here, we present a 49 year old male presented with slowly growing left supraorbital swelling for 3 years. This swelling was a firm mass with destruction of anterior table of frontal bone. Diagnostic radiological work-up showed a mass in left frontal sinus, mass excised with external approach. Reporting this case with its clinical, radiological and histopathological images should add significant material to the literature for further studies of GCT of paranasal sinuses.

scholarly journals New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRβ Signaling

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3543
Author(s):  
Michal Mahdal ◽  
Jakub Neradil ◽  
Peter Mudry ◽  
Silvia Paukovcekova ◽  
Iva Staniczkova Zambo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cells ◽  
Growth Factor Receptor ◽  
Metastatic Potential ◽  
Giant Cells ◽  
Cell Tumor ◽  
Primary Bone Tumor

Giant-cell tumor of bone (GCTB) is an intermediate type of primary bone tumor characterized by locally aggressive growth with metastatic potential. The aim of this study was to identify new druggable targets among the cell signaling molecules involved in GCTB tumorigenesis. Profiles of activated signaling proteins in fresh-frozen tumor samples and tumor-derived cell lines were determined using phosphoprotein arrays. Analysis of the obtained data revealed epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor beta (PDGFRβ) as potential targets, but only the PDGFR inhibitor sunitinib caused a considerable decrease in stromal cell viability in vitro. Furthermore, in the case of a 17-year-old patient suffering from GCTB, we showed that the addition of sunitinib to the standard treatment of GCTB with the monoclonal antibody denosumab resulted in the complete depletion of multinucleated giant cells and mononuclear stromal cells in the tumor tissue. To summarize, the obtained data showed that a specific receptor tyrosine kinase (RTK) signaling pattern is activated in GCTB cells and plays an important role in the regulation of cell proliferation. Thus, activated RTKs and their downstream signaling pathways represent useful targets for precision treatment with low-molecular-weight inhibitors or with other types of modern biological therapy.

Arthroscopic Management of Giant Cell Tumor of the Calcaneus

2021 ◽  
pp. 193864002110291
Author(s):  
I Gede Eka Wiratnaya ◽  
I Wayan Subawa ◽  
Putu Astawa ◽  
Hans Kristian Nugraha
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
High Speed ◽  
Lung Metastases ◽  
Weight Bearing ◽  
Cell Tumor ◽  
Lytic Lesion ◽  
Full Weight Bearing ◽  
Recurrent Pain ◽  
Retrospective Case

Giant cell tumor of the calcaneal bone is a very rare entity and generally seen in the 30 to 40 years age group. We report a case of a 17-year-old male with giant cell tumor of the calcaneus, presented with left heel pain without another obvious physical abnormality. Radiographs showed a lobulated, well-defined, lytic lesion of the calcaneus with narrow transitional zone without periosteal reaction, no extraosseal spread, and no lung metastases. Arthroscopic procedure was done directly for both diagnostic and curative procedures. All soft, grayish lesions were completely removed arthroscopically using direct lateral portals and the suspected reactive zones debrided using high-speed burr and injected with corticosteroid. Histopathology confirmed the suspected diagnosis. The postoperative clinical course was uneventful with immediate pain relief and full weight bearing and movement allowed soon. The patient had no recurrent pain as well as recurrent radiographic lesions, and normal joint mobility 9 months postoperatively. Considering the accessibility of the lesion, giant cell tumor of the calcaneal bone can be successfully treated arthroscopically using direct lateral approach. Levels of Evidence: Therapeutic, Level IV: Retrospective, case report

scholarly journals Giant Cell Tumor of the Knee. Case Report of a Potentially Aggressive Benign Tumor

2018 ◽  
Vol 3 (1) ◽  
pp. 735-740
Author(s):  
Álvaro Cerda ◽  
Ricardo Tolosa ◽  
Ramón Hernandez
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Benign Tumor ◽  
Signs And Symptoms ◽  
Cell Tumor ◽  
Primary Bone Tumor ◽  
Appropriate Treatment ◽  
Therapeutic Procedures ◽  
Primary Bone ◽  
Third Age Of Life

The giant cell tumor of bone (OCD) is a primary bone tumor that occurs most frequently in the third age of life, being located mainly at the distal femur. The development of a biopsy to establish the diagnosis and to begin appropriate treatment quickly is a fundamental to establish as early as possible surgical resection procedure. In this article a case of TOCG is presented in a patient of 30 years. Its etiology, signs and symptoms, diagnosis, as well as an adequate diagnostic and therapeutic procedures to achieve a positive resolution of this pathology is discussed.

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