scholarly journals A novel method for early diagnosis of Alzheimer’s disease based on higher-order spectral estimation of spontaneous speech signals

2016 ◽  
Vol 10 (6) ◽  
pp. 495-503 ◽  
Author(s):  
Mahda Nasrolahzadeh ◽  
Zeynab Mohammadpoory ◽  
Javad Haddadnia
2018 ◽  
Vol 12 (6) ◽  
pp. 583-596 ◽  
Author(s):  
Mahda Nasrolahzadeh ◽  
Zeynab Mohammadpoory ◽  
Javad Haddadnia

GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.


Author(s):  
Atif Mehmood ◽  
Shuyuan yang ◽  
Zhixi feng ◽  
Min wang ◽  
AL Smadi Ahmad ◽  
...  

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